(Q40146754)

17 September 2017

Tau aggregation and toxicity in a cell culture model of tauopathy (English)

1 reference

17 September 2017

Bhaswati Bandyopadhyay

1

1 reference

17 September 2017

Guibin Li

2

1 reference

17 September 2017

Haishan Yin

3

1 reference

17 September 2017

Jeff Kuret

4

1 reference

17 September 2017

language of work or name

English

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publication date

11 April 2007

1 reference

Journal of Biological Chemistry

17 September 2017

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17 September 2017

282

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17 September 2017

16454-16464

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17 September 2017

22

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Template-assisted filament growth by parallel stacking of tau.

17 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Transcriptional and conformational changes of the tau molecule in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Tangled areas of Alzheimer brain have upregulated levels of exon 10 containing tau mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Neuropathological stageing of Alzheimer-related changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Tau is a candidate gene for chromosome 17 frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Altered microtubule organization in small-calibre axons of mice lacking tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Triggers of full-length tau aggregation: a role for partially folded intermediates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Congo red populates partially unfolded states of an amyloidogenic protein to enhance aggregation and amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

10-nm filaments are induced to collapse in living cells microinjected with monoclonal and polyclonal antibodies against tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Electron microscopy as a quantitative method for investigating tau fibrillization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Dynamic instability of microtubule growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Development of a novel flow cytometric cell-mediated cytotoxicity assay using the fluorophores PKH-26 and TO-PRO-3 iodide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Antibody-dependent cell-mediated cytotoxicity: a flow cytometry-based assay using fluorophores

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Purification of paired helical filament tau and normal tau from human brain tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Ligand-dependent inhibition and reversal of tau filament formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Congo red, doxycycline, and HSP70 overexpression reduce aggregate formation and cell death in cell models of oculopharyngeal muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Proteasomal degradation of tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

The rate of Tau synthesis is differentially regulated during postnatal development in mouse cerebellum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Sugar transport by mammalian members of the SLC26 superfamily of anion-bicarbonate exchangers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Alzheimer's disease: paired helical filaments and cytomembranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Evaluating triggers and enhancers of tau fibrillization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Subicular Dendritic Arborization in Alzheimer's Disease Correlates with Neurofibrillary Tangle Density

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Synaptic loss in Alzheimer's disease and other dementias

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Polyglutamine expansion diseases: failing to deliver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Nonsaturable binding indicates clustering of tau on the microtubule surface in a paired helical filament-like conformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700192200

21 January 2018

Identifiers

DOI

10.1074/JBC.M700192200

1 reference

17 September 2017

1 reference