(Q40151022)

English

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV.

scientific article published on June 2017

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. (English)

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

3

object named as

Ruben Abagyan

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object named as

Yi Zheng

1

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Raymond C. Stevens

object named as

Raymond C Stevens

5

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author name string

Gye Won Han

2

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

Beili Wu

4

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

Vadim Cherezov

6

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

Irina Kufareva

7

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

Tracy M Handel

8

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

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publication date

1 June 2017

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

46

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

6

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

1005-1017.e5

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

Staphylococcus aureus Leukocidin LukED and HIV-1 gp120 Target Different Sequence Determinants on CCR5.

1 reference

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10 July 2018

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

1 reference

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10 July 2018

Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices

1 reference

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10 July 2018

Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry.

1 reference

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10 July 2018

Generating Chemokine Analogs with Enhanced Pharmacological Properties Using Phage Display

1 reference

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10 July 2018

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1 reference

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A scalable low-cost cGMP process for clinical grade production of the HIV inhibitor 5P12-RANTES in Pichia pastoris

1 reference

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10 July 2018

Molecular Gymnastics: Mechanisms of HIV-1 Resistance to CCR5 Antagonists and Impact on Virus Phenotypes

1 reference

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1 reference

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Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism.

1 reference

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10 July 2018

Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

1 reference

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10 July 2018

Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Biased and g protein-independent signaling of chemokine receptors

1 reference

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10 July 2018

Elucidating a key anti-HIV-1 and cancer-associated axis: the structure of CCL5 (Rantes) in complex with CCR5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Molecular control of δ-opioid receptor signalling

1 reference

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10 July 2018

The chemokine system, and its CCR5 and CXCR4 receptors, as potential targets for personalized therapy in cancer

1 reference

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10 July 2018

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Allosteric model of maraviroc binding to CC chemokine receptor 5 (CCR5).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Pharmacological modulation of chemokine receptor function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

REFMAC5 for the refinement of macromolecular crystal structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Overview of the CCP4 suite and current developments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

JBluIce-EPICS control system for macromolecular crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Features and development of Coot

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Phasercrystallographic software

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Crystallizing membrane proteins using lipidic mesophases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Highly potent, fully recombinant anti-HIV chemokines: reengineering a low-cost microbicide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Microscale fluorescent thermal stability assay for membrane proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Inference of macromolecular assemblies from crystalline state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Structural and molecular interactions of CCR5 inhibitors with CCR5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

The crown and stem of the V3 loop play distinct roles in human immunodeficiency virus type 1 envelope glycoprotein interactions with the CCR5 coreceptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelope glycoproteins: differences in primary structural requirements for RANTES, MIP-1 alpha, and vMIP-II Binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Mapping the determinants of the CCR5 amino-terminal sulfopeptide interaction with soluble human immunodeficiency virus type 1 gp120-CD4 complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein.

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

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Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

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Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist.

1 reference

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10 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

10 July 2018

Analysis and refinement of criteria for predicting the structure and relative orientations of transmembranal helical domains

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A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5572563

20 August 2018

Fine definition of a conserved CCR5-binding region on the human immunodeficiency virus type 1 glycoprotein 120

1 reference

https://pubmed.ncbi.nlm.nih.gov/28636951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CC chemokine MIP-1 beta can function as a monomer and depends on Phe13 for receptor binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/28636951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed, Ligase-Independent Mutagenesis (SLIM) for highly efficient mutagenesis of plasmids greater than 8kb

1 reference

https://pubmed.ncbi.nlm.nih.gov/28636951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.IMMUNI.2017.05.002

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 July 2018

http://europepmc.org/abstract/PMC/5572563

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