(Q40153405)

English

Specific mTOR inhibitor rapamycin enhances cytotoxicity induced by alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU) in human U251 malignant glioma cells

scientific article published on 28 March 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Specific mTOR inhibitor rapamycin enhances cytotoxicity induced by alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU) in human U251 malignant glioma cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

1 reference

based on heuristic

inferred from title

author name string

Kazuhiro Tanaka

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Takashi Sasayama

2

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Katsu Mizukawa

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Atsufumi Kawamura

4

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Takeshi Kondoh

5

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Kohkichi Hosoda

6

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Toshiyoshi Fujiwara

7

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Eiji Kohmura

8

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

publication date

28 March 2007

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Journal of Neuro-Oncology

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

84

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

233-244

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas

1 reference

https://api.crossref.org/works/10.1007%2FS11060-007-9371-X

21 January 2018

Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS11060-007-9371-X

21 January 2018

WAF1/CIP1 increases the susceptibility of p53 non-functional malignant glioma cells to cisplatin-induced apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian target of rapamycin inhibition as therapy for hematologic malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to Fas-mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p21WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A non-enzymatic p21 protein inhibitor of stress-activated protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upstream and downstream of mTOR

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of complex relationships between age, p53, epidermal growth factor receptor, and survival in glioblastoma patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome-dependent regulation of p21WAF1/CIP1 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary brain tumours in adults.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin inhibits proteasome activator expression and proteasome activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin inhibits cdk4 activation, p 21(WAF1/CIP1) expression and G1-phase progression in transformed mouse fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR-targeted therapy of cancer with rapamycin derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR and cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of Bcl-2 in bladder cancer cells inhibits apoptosis induced by cisplatin and adenoviral-mediated p53 gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian target of rapamycin inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR regulates cell survival after etoposide treatment in primary AML cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of mammalian G1 cyclin-dependent kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TOR signaling in growth and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle arrest and astrocytic differentiation resulting from PTEN expression in glioma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overcoming cisplatin resistance by mTOR inhibitor in lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation and identification of recombinant adenovirus by liposome-mediated transfection and PCR analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in the treatment of malignant astrocytoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo gene therapy with p53 or p21 adenovirus for prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian target of rapamycin promotes vincristine resistance through multiple mechanisms independent of maintained glycolytic rate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting mTOR signaling for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17390104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.727

Identifiers

10.1007/S11060-007-9371-X

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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