(Q40159491)

English

Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC.

scientific article published on April 2007

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scholarly article

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Europe PubMed Central

PubMed publication ID

18 September 2017

Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC. (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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inferred from title

exposure assessment

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Elaine J Abrams

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object named as

Elaine J Abrams

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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Roberta B Ness

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Europe PubMed Central

PubMed publication ID

18 September 2017

Vernon E Walker

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object named as

Vernon E Walker

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Europe PubMed Central

PubMed publication ID

18 September 2017

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Dale M Walker

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Europe PubMed Central

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18 September 2017

Miriam C. Poirier

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object named as

Miriam C Poirier

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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object named as

Ofelia A Olivero

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Europe PubMed Central

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18 September 2017

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Quanxin Meng

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Europe PubMed Central

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18 September 2017

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object named as

Nancy A Wade

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Europe PubMed Central

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18 September 2017

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Carol J Nesel

1 reference

Europe PubMed Central

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18 September 2017

William L Bigbee

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object named as

William L Bigbee

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Europe PubMed Central

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18 September 2017

author name string

Patricia A Escobar

1

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Europe PubMed Central

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18 September 2017

Richard D Day

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Europe PubMed Central

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18 September 2017

Billy W Day

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Europe PubMed Central

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18 September 2017

J Patrick O'Neill

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Europe PubMed Central

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18 September 2017

publication date

1 April 2007

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Environmental and Molecular Mutagenesis

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Europe PubMed Central

PubMed publication ID

18 September 2017

48

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Europe PubMed Central

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18 September 2017

3-4

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Europe PubMed Central

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18 September 2017

330-343

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Europe PubMed Central

PubMed publication ID

18 September 2017

In vivo somatic mutations in humans: measurement and analysis

1 reference

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Individual variation in somatic mutations of the glycophorin-A gene in neonates in relation to pre-natal factors

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In vivo somatic mutation and segregation at the human glycophorin A (GPA) locus: phenotypic variation encompassing both gene-specific and chromosomal mechanisms.

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The single cell gel electrophoresis assay (comet assay): a European review

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Analysis of mutations in the Tk gene of Tk(+/-) mice treated as neonates with 3'-azido-3'-deoxythymidine (AZT).

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Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT

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Nonclinical toxicology studies with zidovudine: genetic toxicity tests and carcinogenicity bioassays in mice and rats

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Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group

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Induction of micronuclei by low doses of azidothymidine (AZT)

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Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in mice

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The comet assay: a comprehensive review

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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

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Oxidative stress and mitochondrial DNA repair: implications for NRTIs induced DNA damage

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Direct immunofluorescence labeling provides an improved method for the glycophorin A somatic cell mutation assay

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Measurements of the frequency of human erythrocytes with gene expression loss phenotypes at the glycophorin A locus

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Strategies to prevent mother-to-child transmission of HIV.

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Doses and time-dependent effects of 3'-azido-3'-deoxythymidine on T47D human breast cancer cells in vitro

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Relationships between DNA incorporation, mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine

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Mutagenicity and loss of heterozygosity at the APRT locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine

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Zidovudine-didanosine coexposure potentiates DNA incorporation of zidovudine and mutagenesis in human cells

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7 January 2021

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Molecular analysis of mutations at the HPRT and TK loci of human lymphoblastoid cells after combined treatments with 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosinedagger

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Stimulation of DNA glycosylase activity of OGG1 by NEIL1: functional collaboration between two human DNA glycosylases

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Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay

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Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells

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Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys

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Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs

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Azidothymidine induces apoptosis in mouse myeloma cell line Sp2/0.

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Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing

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Interference with cell cycle progression and induction of apoptosis by dideoxynucleoside analogs

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10.1002/EM.20285

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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