(Q40170852)

18 September 2017

title

Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle (English)

1 reference

18 September 2017

1 reference

Guise CP

1

1 reference

18 September 2017

Grove JI

series ordinal

2

1 reference

18 September 2017

Hyde EI

series ordinal

3

1 reference

18 September 2017

Searle PF

series ordinal

4

1 reference

18 September 2017

publication date

15 February 2007

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18 September 2017

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18 September 2017

volume

14

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18 September 2017

issue

8

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18 September 2017

page(s)

690-698

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The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).

18 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Nature of the SOS-inducing signal in Escherichia coli. The involvement of DNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

DNA damage and prophage induction and toxicity of nitrofurantoin in Escherichia coli and Vibrio cholerae cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Comparative DNA damage and repair induced by misonidazole, CB 1954 and RSU 1069.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Alanine-scanning mutagenesis reveals a cytosine deaminase mutant with altered substrate preference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

Genetics of Nitrofurazone Resistance in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

inferred from DOI database lookup

7 January 2021

based on heuristic

Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

inferred from DOI database lookup

7 January 2021

based on heuristic

The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302919

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.GT.3302919

1 reference

Dimensions Publication ID

18 September 2017

1035606721

0 references

1 reference