(Q45857167)

17 December 2017

title

Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling (English)

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17 December 2017

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Christians FC

1

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17 December 2017

Scapozza L

2

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17 December 2017

Crameri A

3

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17 December 2017

Folkers G

4

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17 December 2017

Stemmer WP

5

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17 December 2017

publication date

1 March 1999

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17 December 2017

published in

Nature Biotechnology

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17 December 2017

volume

17

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17 December 2017

issue

3

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17 December 2017

page(s)

259-264

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/7003

exact match

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cites work

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

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Rapid evolution of a protein in vitro by DNA shuffling

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Directed evolution of a fucosidase from a galactosidase by DNA shuffling and screening

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Improved green fluorescent protein by molecular evolution using DNA shuffling

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Improved properties of FLP recombinase evolved by cycling mutagenesis

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DNA shuffling of a family of genes from diverse species accelerates directed evolution

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Enhanced degradation of polychlorinated biphenyls by directed evolution of biphenyl dioxygenase

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Direct cell killing by suicide genes

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Viral thymidine kinases and their relatives

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Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy

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Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences

21 January 2018

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The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue

21 January 2018

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21 January 2018

1 reference

Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands

21 January 2018

1 reference

Drug resistance of herpes simplex virus type 1--structural considerations at the molecular level of the thymidine kinase.

21 January 2018

1 reference

Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation

21 January 2018

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Applications of DNA shuffling to pharmaceuticals and vaccines

21 January 2018

1 reference

X-ray analysis of azido-thymidine diphosphate binding to nucleoside diphosphate kinase

21 January 2018

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Comparison of simple potential functions for simulating liquid water

21 January 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

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A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

21 January 2018

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Further development of hydrogen bond functions for use in determining energetically favorable binding sites on molecules of known structure. 1. Ligand probe groups with the ability to form two hydrogen bonds

21 January 2018

1 reference

The bottleneck in AZT activation

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Improving AZT efficacy

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

6 Statistical analysis of enzyme kinetic data

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/7003

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17 December 2017

Dimensions Publication ID

1042088583

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17 December 2017