(Q40173379)

18 September 2017

1 reference

title

Biologic and clinical importance of proinsulin (English)

1 reference

18 September 2017

Biologic and Clinical Importance of Proinsulin (English)

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

9 October 2023

author name string

D. C. Robbins

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6369137

9 October 2023

H. S. Tager

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6369137

9 October 2023

A. H. Rubenstein

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6369137

9 October 2023

language of work or name

English

0 references

publication date

1 May 1984

1 reference

18 September 2017

3 May 1984

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6369137

full work available at URL

9 October 2023

http://www.nejm.org/doi/pdf/10.1056/NEJM198405033101807

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The New England Journal of Medicine

9 October 2023

published in

1 reference

18 September 2017

volume

310

1 reference

18 September 2017

issue

18

1 reference

18 September 2017

page(s)

1165-1175

1 reference

The amino-acid sequence in the glycyl chain of insulin. I. The identification of lower peptides from partial hydrolysates

18 September 2017

cites work

1

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The amino-acid sequence in the glycyl chain of insulin. II. The investigation of peptides from enzymic hydrolysates

9 October 2023

2

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma

9 October 2023

3

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Insulin biosynthesis: evidence for a precursor

9 October 2023

4

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Porcine proinsulin: characterization and amino acid sequence

9 October 2023

5

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Isolation of a proinsulin connecting peptide fragment (C-peptide) from bovine and human pancreas

9 October 2023

6

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Sequence of the human insulin gene

9 October 2023

7

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Partial purification and characterization of the mRNA for rat preproinsulin

9 October 2023

8

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Identification of the major polyadenylylated transcription products and the genes active in their synthesis in a rat insulinoma

9 October 2023

9

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Evidence for proinsulin in human urine and serum.

9 October 2023

10

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

"Big insulin": a new component of plasma insulin detected by immunoassay

9 October 2023

11

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The insulin gene is located on the short arm of chromosome 11 in humans

9 October 2023

13

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

9 October 2023

14

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The structure and evolution of the two nonallelic rat preproinsulin genes

9 October 2023

15

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Events in the evolution of pre-proinsulin

9 October 2023

16

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Biggest challenge since the double helix

9 October 2023

17

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Nucleotide sequence of a cDNA clone encoding human preproinsulin

9 October 2023

18

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Translation of messenger ribonucleic acid from isolated pancreatic islets and human insulinomas

9 October 2023

19

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Proinsulin precursors in isolated rat pancreatic islets

9 October 2023

20

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Cell-free synthesis of rat preproinsulins: characterization and partial amino acid sequence determination

9 October 2023

21

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components

9 October 2023

22

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Cell-free synthesis of fish preproinsulin, and processing by heterologous mammalian microsomal membranes

9 October 2023

23

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Detection and kinetic behavior of preproinsulin in pancreatic islets

9 October 2023

24

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Role of ATP in the Intracellular Translocation of Proinsulin and Insulin in the Rat Pancreatic B Cell

9 October 2023

26

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Glucose stimulation of the proinsulin synthesis in isolated pancreatic islets without increasing amount of proinsulin mRNA

9 October 2023

27

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Transcriptional and Translational Control of Glucose-Stimulated (Pro)insulin Biosynthesis

9 October 2023

28

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Translational control of proinsulin synthesis by glucose

9 October 2023

29

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Glucose stimulated proinsulin biosynthesis rates of turn off after cessation of the stimulus

9 October 2023

30

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The Effects of Fasting and Feeding on Preproinsulin Messenger RNA in Rats

9 October 2023

32

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Conversion of proinsulin to insulin in a subcellular fraction from rat islets

9 October 2023

33

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Characterization of proinsulin- and proglucagon-converting activities in isolated islet secretory granules

9 October 2023

36

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease

9 October 2023

37

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

On the Biosynthesis, Intracellular Transport and Mechanism of Conversion of Proinsulin to Insulin and C-Peptide

9 October 2023

38

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

A light and electron microscopic study of cellular differentiation in the pancreatic islets of the mouse

9 October 2023

39

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Beta granule formation in isolated islets of langerhans: a study by electron microscopic radioautography

9 October 2023

40

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Biosynthesis of proinsulin and other islet cell proteins in pancreatic beta cells of the rat: a radioautographic evaluation of glucose effects in vitro

9 October 2023

41

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Subcellular Localization of Proinsulin to Insulin Conversion in Isolated Rat Islets

9 October 2023

42

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Differences in the nature of the interaction of insulin and proinsulin with zinc

9 October 2023

43

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Role of zinc in insulin biosynthesis. Some possible zinc-insulin interactions in the pancreatic B-cell

9 October 2023

45

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood

9 October 2023

46

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Direct measurement of proinsulin in human plasma by the use of an insulin-degrading enzyme

9 October 2023

49

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Indirect two-site immunoradiometric assay of rat and mouse proinsulin

9 October 2023

51

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Specific and direct radioimmunoassay for human proinsulin in serum

9 October 2023

52

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Electrophoretic characterization of circulating human proinsulin and insulin

9 October 2023

53

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Characterization of proinsulin-insulin intermediates in human plasma

9 October 2023

54

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Properties of Proinsulin and Related Polypeptide

9 October 2023

55

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

9 October 2023

Human serum proinsulin

60

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

9 October 2023

61

19

562

Owens

1980

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Plasma insulin: fluctuations in the "big" insulin component in man after glucose and other stimuli

9 October 2023

62

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Effect of porcine proinsulin in vitro on adipose tissue and diaphragm of the normal rat

9 October 2023

63

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Studies on the biological activity of porcine proinsulin

9 October 2023

64

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Proinsulin: Metabolic Effects in the Human Forearm

9 October 2023

65

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Antilipolytic Effect of Porcine Proinsulin

9 October 2023

66

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Radioreceptor Assay of Insulin: Comparison of Plasma and Pancreatic Insulins and Proinsulins

9 October 2023

67

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

9 October 2023

69

31

59A

Revers

1983

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

9 October 2023

70

31

544A

Bergenstal

1983

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Free and total insulin integrated concentrations in insulin dependent diabetes

9 October 2023

71

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Hypoglycemic Activity and Immunological Half-life of Porcine Insulin and Proinsulin in Baboons and Swine

9 October 2023

72

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Metabolism of endogenous proinsulin and insulin in man.

9 October 2023

73

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Metabolism of proinsulin, insulin, and C-peptide in the rat

9 October 2023

74

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The Metabolism of Proinsulin and Insulin by the Liver

9 October 2023

75

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The Handling of Insulin, Proinsulin, and C-peptide by the Isolated Rat Kidney

9 October 2023

76

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The biological and immunological properties of pork and beef insulin, proinsulin, and connecting peptides

9 October 2023

77

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Serum Proinsulin in Children and Adolescents with Chemical Diabetes

9 October 2023

78

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Insulin and proinsulin in normal and chemical diabetic children.

9 October 2023

79

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Serum proinsulin in normal and gestational diabetic pregnancy

9 October 2023

80

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Carbohydrate Metabolism in Pregnancy: XIII. Relationships Between Plasma Insulin and Proinsulin During Late Pregnancy in Normal and Diabetic Subjects

9 October 2023

81

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Circulating proinsulin-like component in man: increased proportion in hypoinsulinemic states.

9 October 2023

82

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Circulating proinsulin in patients with maturity onset diabetes

9 October 2023

83

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Abnormalities in circulating beta cell peptides in chronic renal failure: comparison of C-peptide, proinsulin and insulin

9 October 2023

84

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Hypersecretion of proinsulin in thyrotoxicosis.

9 October 2023

85

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Diagnosis and Medical Management of Insulinomas

9 October 2023

86

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Significance of human plasma insulin Sephadex fractions

9 October 2023

87

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Proinsulin secretion by a pancreatic beta-cell adenoma. Proinsulin and C-peptide secretion.

9 October 2023

89

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Insulin and Proinsulin Content of Pancreases from Diabetic and Nondiabetic Subjects

9 October 2023

90

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Plasma proinsulin in patients with functioning pancreatic islet cell tumors.

9 October 2023

91

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Insulinoma with Low Circulating Insulin Levels: The Diagnostic Value of Proinsulin Measurements

9 October 2023

92

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

In vitro studies of the rate of proinsulin and insulin turnover in seven human insulinomas.

9 October 2023

93

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Familial hyperproinsulinemia. An autosomal dominant defect

9 October 2023

94

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Familial hyperproinsulinemia: partial characterization of circulating proinsulin-like material

9 October 2023

95

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

A human proinsulin variant at arginine 65

9 October 2023

98

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Familial hyperproinsulinemia. Two cohorts secreting indistinguishable type II intermediates of proinsulin conversion

9 October 2023

99

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

9 October 2023

100

31

387A

Grupposo

1983

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Evolution of structure and function of proteases

9 October 2023

101

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Diabetes due to secretion of an abnormal insulin.

9 October 2023

102

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

A structurally abnormal insulin causing human diabetes

9 October 2023

103

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Isolation and properties of proinsulin, intermediate forms, and other minor components from crystalline bovine insulin

9 October 2023

106

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The Prevalence of Proinsulin-Specific Antibodies in Diabetic Patients

9 October 2023

107

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Decrease of antibodies to insulin, proinsulin and contaminating hormones after changing treatment from conventional beef to purified pork insulin.

9 October 2023

109

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Insulin, C-peptide, and Proinsulin in Nondiabetics and Insulin-treated Diabetics: Characterization of the Proinsulin in Insulin-treated Diabetics

9 October 2023

110

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The immunogenicity of insulin preparation. Antibody levels before and after transfer to highly purified porcine insulin

9 October 2023

111

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

The clinical significance of highly purified pig-insulin preparations

9 October 2023

112

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Plasma proinsulin-like material in insulin treated diabetics

9 October 2023

114

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Human proinsulin in insulin-treated juvenile diabetics

9 October 2023

115

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Human insulin from recombinant DNA technology

9 October 2023

116

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Expression in Escherichia coli of chemically synthesized genes for human insulin

9 October 2023

117

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Bacterial production of human insulin

9 October 2023

118

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Expression in Escherichia coli of a chemically synthesized gene for a "mini-C" analog of human proinsulin

9 October 2023

120

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Chemical, physical, and biologic properties of biosynthetic human insulin

9 October 2023

121

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Clinical pharmacologic studies with human insulin (recombinant DNA).

9 October 2023

122

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Human insulin produced by recombinant DNA technology: safety and hypoglycaemic potency in healthy men

9 October 2023

123

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Bacteria mature preproinsulin to proinsulin

9 October 2023

124

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Biosynthesis and periplasmic segregation of human proinsulin in Escherichia coli

9 October 2023

125

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

Formation of proinsulin by immobilized Bacillus subtilis

9 October 2023

126

1 reference

https://api.crossref.org/works/10.1056/NEJM198405033101807

9 October 2023

Identifiers

1 reference

18 September 2017

1 reference