(Q40177748)

English

A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway

scientific article published on 29 January 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

author name string

Carie AE

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Sebti SM

2

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

language of work or name

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publication date

29 January 2007

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

26

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

26

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

3777-3788

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210172

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G-protein-coupled receptors: turn-ons and turn-offs

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Activated 3',5'-cyclic AMP-dependent protein kinase is sufficient to induce neuroendocrine-like differentiation of the LNCaP prostate tumor cell line

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Untying the regulation of the Raf-1 kinase

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Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels

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Pharmacological inhibitors of MAPK pathways.

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A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

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Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells

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Platelet-derived growth factor (PDGF) receptor activation in cell transformation and human malignancy

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Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells

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Mechanism of inhibition of Raf-1 by protein kinase A.

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The ups and downs of MEK kinase interactions

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The Hallmarks of Cancer

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Alpha-methylacyl-CoA racemase: a multi-institutional study of a new prostate cancer marker.

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Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells.

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

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Approval summary for erlotinib for treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen

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Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

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The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

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Targeting transcription factors for cancer therapy

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Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1.

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PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1.

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Development of anticancer drugs targeting the MAP kinase pathway

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Increasing cAMP attenuates activation of mitogen-activated protein kinase

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

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Identifiers

10.1038/SJ.ONC.1210172

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

ResearchGate publication ID

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