(Q40184671)

18 September 2017

title

Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line (English)

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18 September 2017

6

Ludger Klein-Hitpass

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18 September 2017

Silke Erdmann

1

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18 September 2017

Sabine Senkel

2

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18 September 2017

Tanja Arndt

3

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18 September 2017

Belén Lucas

4

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18 September 2017

Jörn Lausen

5

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18 September 2017

Gerhart U Ryffel

7

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18 September 2017

Heike Thomas

8

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18 September 2017

publication date

1 January 2007

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18 September 2017

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18 September 2017

volume

388

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18 September 2017

issue

1

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18 September 2017

page(s)

91-106

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Gene ontology: tool for the unification of biology

18 September 2017

cites work

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A transcription factor regulatory circuit in differentiated pancreatic cells

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

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Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

21 January 2018

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Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells

21 January 2018

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Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4alpha

21 January 2018

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Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand

21 January 2018

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Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

21 January 2018

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Maturity-onset diabetes of the young Type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4alpha) gene impair recruitment of p300, a key transcriptional co-activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2007.011

Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms.

21 January 2018

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Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

21 January 2018

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Critical structural elements and multitarget protein interactions of the transcriptional activator AF-1 of hepatocyte nuclear factor 4.

21 January 2018

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Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes

21 January 2018

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HNF-4alpha: from MODY to late-onset type 2 diabetes

21 January 2018

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Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity

21 January 2018

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Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

21 January 2018

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Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells.

21 January 2018

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The activation function-1 of hepatocyte nuclear factor-4 is an acidic activator that mediates interactions through bulky hydrophobic residues

21 January 2018

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Functional properties of the R154X HNF-4alpha protein generated by a mutation associated with maturity-onset diabetes of the young, type 1.

21 January 2018

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Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree

21 January 2018

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Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors

21 January 2018

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RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

21 January 2018

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Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene

21 January 2018

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Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor

21 January 2018

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Apoptosis-inducing factor: vital and lethal

21 January 2018

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An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types

21 January 2018

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Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis

21 January 2018

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Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

21 January 2018

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Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences

21 January 2018

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Distinct promoter elements mediate endodermal and mesodermal expression of the HNF1alpha promoter in transgenic Xenopus.

21 January 2018

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Transcriptional networks controlling pancreatic development and beta cell function.

21 January 2018

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MODY1 mutation Q268X in hepatocyte nuclear factor 4alpha allows for dimerization in solution but causes abnormal subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2007.011

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

21 January 2018

1 reference

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Molecular characterization of mitochondrial apoptosis-inducing factor

21 January 2018

1 reference

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Characterization of a dominant negative mutant form of the HNF-4 orphan receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2007.011

A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2007.011

Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2007.011

Expression of HNF4alpha isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3' end splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2007.011

Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2007.011

C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4

21 January 2018

1 reference

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FLP and Cre recombinase function in Xenopus embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2007.011

DNA binding is required for the apoptogenic action of apoptosis inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2007.011

21 January 2018

Identifiers

DOI

10.1515/BC.2007.011

1 reference

18 September 2017

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