(Q40202640)

18 September 2017

title

Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells (English)

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18 September 2017

main subject

endoplasmic reticulum

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J Aaron Matthews

1

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18 September 2017

Jonathan L Belof

series ordinal

2

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18 September 2017

Mildred Acevedo-Duncan

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3

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18 September 2017

Robert L Potter

series ordinal

4

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18 September 2017

publication date

30 November 2006

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Molecular and Cellular Biochemistry

18 September 2017

published in

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18 September 2017

volume

298

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18 September 2017

issue

1-2

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18 September 2017

page(s)

109-123

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https://scigraph.springernature.com/pub.10.1007/s11010-006-9358-5

18 September 2017

exact match

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cites work

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O-glycosylation of Sp1 and transcriptional regulation of the calmodulin gene by insulin and glucagon

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The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

21 January 2018

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The 170-kDa glucose-regulated stress protein is an endoplasmic reticulum protein that binds immunoglobulin

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Increased flux through the hexosamine biosynthesis pathway inhibits glucose transport acutely by activation of protein kinase C.

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Defective Akt activation is associated with glucose- but not glucosamine-induced insulin resistance

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Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

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The effects of glucose and the hexosamine biosynthesis pathway on glycogen synthase kinase-3 and other protein kinases that regulate glycogen synthase activity

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12 December 2020

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

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12 December 2020

Mechanism of activation of protein kinase B by insulin and IGF-1

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12 December 2020

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12 December 2020

Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model

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12 December 2020

Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway.

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Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinases A and C.

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Glucose attenuation of memory impairments.

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Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.

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Glucosamine-induced activation of glycogen biosynthesis in isolated adipocytes. Evidence for a rapid allosteric control mechanism within the hexosamine biosynthesis pathway

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12 December 2020

Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction

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12 December 2020

Regulation of neuronal survival by the serine-threonine protein kinase Akt

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12 December 2020

Endothelial cell-astrocyte interactions. A cellular model of the blood-brain barrier

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12 December 2020

Hyperosmolality activates Akt and regulates apoptosis in renal tubular cells

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12 December 2020

Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress

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12 December 2020

A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance

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12 December 2020

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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12 December 2020

Selective decrease of membrane-associated PKC-alpha and PKC-epsilon in response to elevated intracellular O-GlcNAc levels in transformed human glial cells

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12 December 2020

C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state

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12 December 2020

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

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12 December 2020

The pathobiology of diabetic complications: a unifying mechanism

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12 December 2020

Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons

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12 December 2020

Effects of streptozotocin-induced diabetes on rough endoplasmic reticulum and lysosomes of rat liver

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12 December 2020

Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

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12 December 2020

Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol

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Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP.

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12 December 2020

Glucosamine induces lipid accumulation and adipogenic change in C2C12 myoblasts.

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12 December 2020

Induced hsp70 is in small, cytoplasmic complexes in a cell culture model of renal ischemia: a comparative study with heat shock

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12 December 2020

Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.

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12 December 2020

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

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12 December 2020

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

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12 December 2020

Oxidative and nitrosative stress in brain mitochondria of diabetic rats

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12 December 2020

Antioxidant N-acetylcysteine restores systemic nitric oxide availability and corrects depressions in arterial blood pressure and heart rate in diabetic rats.

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12 December 2020

Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation.

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12 December 2020

Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes.

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12 December 2020

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

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12 December 2020

Cognition and synaptic plasticity in diabetes mellitus

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12 December 2020

Transcriptional regulation of transforming growth factor beta1 by glucose: investigation into the role of the hexosamine biosynthesis pathway

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12 December 2020

Insulin signalling and the regulation of glucose and lipid metabolism

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12 December 2020

Contribution of the PI 3-kinase/Akt survival pathway toward osmotic preconditioning

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12 December 2020

Diabetes-induced abnormalities in ER calcium mobilization in primary and secondary nociceptive neurons.

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12 December 2020

Activation of PI 3-kinase by the hexosamine biosynthesis pathway

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12 December 2020

Dynamic actions of glucose and glucosamine on hexosamine biosynthesis in isolated adipocytes: differential effects on glucosamine 6-phosphate, UDP-N-acetylglucosamine, and ATP levels

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12 December 2020

Glucosamine-induced phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase

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12 December 2020

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

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12 December 2020

Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus.

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12 December 2020

Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3.

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12 December 2020

The IRS-signalling system: a network of docking proteins that mediate insulin action

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12 December 2020

Streptozotocin-induced beta-cell death is independent of its inhibition of O-GlcNAcase in pancreatic Min6 cells

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12 December 2020

O-GlcNAc modification of nucleocytoplasmic proteins and diabetes

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12 December 2020

Cell-type specific regulation of calreticulin and Bcl-2 expression by mood stabilizer drugs

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12 December 2020

Glucose transport to the brain: a systems model

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12 December 2020

Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance

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12 December 2020

Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death

1 reference

12 December 2020

Cellular composition of a cerebral hemisphere primary culture

1 reference

12 December 2020

Establishment of a line of human fetal glial cells that supports JC virus multiplication

1 reference

12 December 2020

Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

1 reference

12 December 2020

Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress.

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12 December 2020

Role of translocation in the activation and function of protein kinase B

1 reference

12 December 2020

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1 reference

12 December 2020

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

12 December 2020

Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats

1 reference

12 December 2020

The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase

1 reference

12 December 2020

Glucose-induced insulin resistance of phosphatidylinositol 3'-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway

1 reference

12 December 2020

Astrocyte-derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro.

1 reference

12 December 2020

Activation of the hexosamine pathway causes oxidative stress and abnormal embryo gene expression: involvement in diabetic teratogenesis

1 reference

12 December 2020

Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3.

1 reference

12 December 2020

Perspective: Hexosamines and nutrient sensing

1 reference

12 December 2020

Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment

1 reference

12 December 2020

Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-ce

1 reference

12 December 2020

In vivo administration of glucosamine inhibited phosphatidylinositol 3-kinase activity without affecting tyrosine phosphorylation of the insulin receptor or insulin receptor substrate in rat adipocytes.

1 reference

12 December 2020

10.1007/S11010-006-9358-5

Identifiers

DOI

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18 September 2017

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