(Q42818875)

7 November 2017

title

Defective Akt activation is associated with glucose- but not glucosamine-induced insulin resistance (English)

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7 November 2017

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Bryce A Nelson

1

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7 November 2017

Katherine A Robinson

series ordinal

2

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7 November 2017

Maria G Buse

series ordinal

3

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7 November 2017

language of work or name

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1 March 2002

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American Journal of Physiology - Endocrinology and Metabolism

7 November 2017

published in

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7 November 2017

volume

282

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7 November 2017

issue

3

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7 November 2017

page(s)

E497-506

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

7 November 2017

cites work

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Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

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Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

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Role of translocation in the activation and function of protein kinase B

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Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport

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Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity

21 January 2018

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Effects of overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT) and glucosamine treatment on translocation of GLUT4 in rat adipose cells

21 January 2018

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

21 January 2018

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

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Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

21 January 2018

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Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

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Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes.

21 January 2018

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Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

21 January 2018

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21 January 2018

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Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP.

21 January 2018

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Rab11 is associated with GLUT4-containing vesicles and redistributes in response to insulin.

21 January 2018

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Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

21 January 2018

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Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport

21 January 2018

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Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes

21 January 2018

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Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin

21 January 2018

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Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle.

21 January 2018

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

21 January 2018

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High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes

21 January 2018

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Signaling pathways in insulin action: molecular targets of insulin resistance

21 January 2018

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Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor

21 January 2018

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In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats

21 January 2018

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

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Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

21 January 2018

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Development of insulin resistance in 3T3-L1 adipocytes

21 January 2018

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Regulation of insulin-stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes

21 January 2018

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

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Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart.

21 January 2018

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Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

21 January 2018

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The IRS-signalling system: a network of docking proteins that mediate insulin action

21 January 2018

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Hyperglycemia decreases glucose uptake in type I diabetes.

21 January 2018

1 reference

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Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats

21 January 2018

1 reference

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10.1152/AJPENDO.00438.2001

21 January 2018

Identifiers

DOI

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7 November 2017

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