(Q40203788)

English

Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.

scientific article published on 27 November 2006

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22 December 2019

Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta (English)

1 reference

Europe PubMed Central

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22 December 2019

Masahide Yamamoto

5

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22 December 2019

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Kurosu T

1

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22 December 2019

Tsuji K

2

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22 December 2019

Kida A

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22 December 2019

Koyama T

4

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22 December 2019

Miura O

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22 December 2019

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27 November 2006

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22 December 2019

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22 December 2019

26

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22 December 2019

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22 December 2019

2975-2987

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22 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210117

0 references

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1 reference

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Regulation of cell apoptosis by protein kinase c delta

1 reference

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The development of imatinib as a therapeutic agent for chronic myeloid leukemia

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The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta

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Superoxide activates mitochondrial uncoupling proteins

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Chronic Myeloid Leukemia — Advances in Biology and New Approaches to Treatment

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Rottlerin, a novel protein kinase inhibitor

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21 January 2018

Mitochondrial uncoupling as a target for drug development for the treatment of obesity

1 reference

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21 January 2018

Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia

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21 January 2018

Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia

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21 January 2018

BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion

1 reference

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21 January 2018

The mitochondrial uncoupling-protein homologues.

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BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells

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21 January 2018

The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade

1 reference

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21 January 2018

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

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Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors

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21 January 2018

Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis

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Targeted CML therapy: controlling drug resistance, seeking cure

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Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence

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21 January 2018

Cytofluorometric quantitation of apoptosis-driven inner mitochondrial membrane permeabilization

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21 January 2018

Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

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21 January 2018

A mutation conferring resistance to imatinib at the time of diagnosis of chronic myelogenous leukemia.

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21 January 2018

Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment.

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21 January 2018

Regulation of actin cytoskeleton in lymphocytes: PKC-delta disrupts IL-3-induced membrane ruffles downstream of Rac1.

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21 January 2018

Loss of response to imatinib: mechanisms and management

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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

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21 January 2018

Overriding imatinib resistance with a novel ABL kinase inhibitor

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21 January 2018

Complex cellular responses to reactive oxygen species

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21 January 2018

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

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21 January 2018

High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy

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21 January 2018

The BCR-ABL story: bench to bedside and back

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21 January 2018

The two major imatinib resistance mutations E255K and T315I enhance the activity of BCR/ABL fusion kinase.

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21 January 2018

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

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21 January 2018

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21 January 2018

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