(Q40218344)

English

Indolinones and anilinophthalazines differentially target VEGF-A- and basic fibroblast growth factor-mediated responses in primary human endothelial cells.

scientific article published on January 2012

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21699503%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Indolinones and anilinophthalazines differentially target VEGF-A- and basic fibroblast growth factor-mediated responses in primary human endothelial cells (English)

1 reference

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5 February 2020

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Sreenivasan Ponnambalam

7

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5 February 2020

Colin W G Fishwick

5

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5 February 2020

author name string

A M Latham

1

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5 February 2020

A F Bruns

2

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5 February 2020

J Kankanala

3

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5 February 2020

A P Johnson

4

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5 February 2020

S Homer-Vanniasinkam

6

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5 February 2020

language of work or name

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publication date

1 January 2012

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5 February 2020

British Journal of Pharmacology

1 reference

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5 February 2020

165

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5 February 2020

1

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5 February 2020

245-259

1 reference

Europe PubMed Central

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5 February 2020

An integrative model for vascular endothelial growth factor A as a tumour biomarker

1 reference

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22 September 2017

Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells

1 reference

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22 September 2017

Fibroblast growth factor signalling: from development to cancer

1 reference

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1 reference

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22 September 2017

Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis.

1 reference

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22 September 2017

De-regulated FGF receptors as therapeutic targets in cancer

1 reference

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22 September 2017

Targeting cancer with small molecule kinase inhibitors

1 reference

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22 September 2017

Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor

1 reference

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22 September 2017

A quantitative analysis of kinase inhibitor selectivity

1 reference

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22 September 2017

Non-canonical fibroblast growth factor signalling in angiogenesis.

1 reference

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22 September 2017

Cancer biomarkers: current issues and future directions.

1 reference

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22 September 2017

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition

1 reference

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22 September 2017

Target practice: lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer

1 reference

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22 September 2017

Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor

1 reference

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22 September 2017

Sunitinib: from rational design to clinical efficacy

1 reference

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22 September 2017

Predicting benefit from anti-angiogenic agents in malignancy

1 reference

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22 September 2017

VEGF receptor signalling - in control of vascular function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

22 September 2017

Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells

1 reference

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22 September 2017

Role of tyrosine kinase inhibitors in cancer therapy

1 reference

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22 September 2017

Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma

1 reference

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22 September 2017

Protein kinase inhibitors: insights into drug design from structure.

1 reference

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22 September 2017

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

22 September 2017

Angiogenesis inhibitors in clinical development; where are we now and where are we going?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

22 September 2017

The biology of VEGF and its receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

22 September 2017

Angiogenesis in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

22 September 2017

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

22 September 2017

Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

22 September 2017

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

22 September 2017

The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

22 September 2017

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

22 September 2017

Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

17 June 2018

Biological activity of substrate-bound basic fibroblast growth factor (FGF2): recruitment of FGF receptor-1 in endothelial cell adhesion contacts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

17 June 2018

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

17 June 2018

FGF-1-dependent proliferative and migratory responses are impaired in senescent human umbilical vein endothelial cells and correlate with the inability to signal tyrosine phosphorylation of fibroblast growth factor receptor-1 substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252981

17 June 2018

N-phenyl-N'-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases

1 reference

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20 August 2018

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1 reference

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20 August 2018

Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.

1 reference

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20 August 2018

The first de novo-designed antagonists of the human NK(2) receptor.

1 reference

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20 August 2018

Endothelial cell confluence regulates Weibel-Palade body formation.

1 reference

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20 August 2018

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

1 reference

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20 August 2018

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1 reference

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20 August 2018

Flk-1 specific kinase inhibitor (SU5416) inhibited the growth of GS-9L glioma in rat brain and prolonged the survival

1 reference

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20 August 2018

Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth factor-induced angiogenesis in vivo and in vitro

1 reference

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20 August 2018

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1 reference

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20 August 2018

Phosphorylation of tyrosine 801 of vascular endothelial growth factor receptor-2 is necessary for Akt-dependent endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21699503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective control of endothelial cell proliferation with a synthetic dimerizer of FGF receptor-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21699503

12 December 2020

based on heuristic

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Identifiers

10.1111/J.1476-5381.2011.01545.X

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Europe PubMed Central

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5 February 2020

release_vy3y4ckjbrfuhfjv43yxdfieiy

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24 November 2022

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mapped directly with Wikidata item

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Europe PubMed Central

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5 February 2020

1 reference

Europe PubMed Central

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5 February 2020

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