(Q40223320)

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Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: Implications for vaccine development

scientific article published on 4 May 2017

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scholarly article

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Europe PubMed Central

18 September 2017

Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: Implications for vaccine development (English)

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Europe PubMed Central

18 September 2017

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Richard T Marconi

4

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9 June 2020

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Jerilyn R Izac

1

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9 June 2020

Lee D Oliver

2

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9 June 2020

Christopher G Earnhart

3

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9 June 2020

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4 May 2017

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18 September 2017

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9 June 2020

35

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9 June 2020

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9 June 2020

3178-3185

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9 June 2020

Lyme borreliosis in dogs and humans in the USA

1 reference

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7 January 2021

Borrelia burgdorferi infections with special reference to horses. A review.

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7 January 2021

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7 January 2021

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Dogs and horses with antibodies to outer-surface protein C as on-time sentinels for ticks infected with Borrelia burgdorferi in New York State in 2011.

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Seroprevalence of Borrelia burgdorferi in Horses Presented for Coggins Testing in Southwest Virginia and Change in Positive Test Results Approximately 1 Year Later

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Serological Reactivity to Borrelia burgdorferi Sensu Lato in Dogs and Horses from Distinct Areas in Romania

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The Lyme vaccine: a cautionary tale

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Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi

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Transcriptional regulation of the ospAB and ospC promoters from Borrelia burgdorferi

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Dynamic changes in Borrelia burgdorferi populations in Ixodes scapularis (Acari: Ixodidae) during transmission: studies at the mRNA level

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Reciprocal expression of ospA and ospC in single cells of Borrelia burgdorferi

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Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine

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OspA immunization decreases transmission of Borrelia burgdorferi spirochetes from infected Peromyscus leucopus mice to larval Ixodes scapularis ticks

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Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice

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Relationship between immunity to Borrelia burgdorferi outer-surface protein A (OspA) and Lyme arthritis

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Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B.

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Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains.

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Construction and analysis of variants of a polyvalent Lyme disease vaccine: approaches for improving the immune response to chimeric vaccinogens.

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An Octavalent Lyme Disease Vaccine Induces Antibodies That Recognize All Incorporated ospC Type-Specific Sequences

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The prevention of Lyme disease with vaccine

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Vaccination as a modality to prevent Lyme disease. A status report

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Efficacy of an OspA vaccine preparation for prevention of Lyme disease in New York State

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Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis.

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An effective second-generation outer surface protein A-derived Lyme vaccine that eliminates a potentially autoreactive T cell epitope

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A Novel multivalent OspA vaccine against Lyme borreliosis is safe and immunogenic in an adult population previously infected with Borrelia burgdorferi sensu lato

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A novel multivalent OspA vaccine against Lyme borreliosis shows promise in Phase I/II studies

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OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine

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Analysis of antibody response in humans to the type A OspC loop 5 domain and assessment of the potential utility of the loop 5 epitope in Lyme disease vaccine development

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Temporal regulation of outer surface proteins of the Lyme-disease spirochaete Borrelia burgdorferi

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Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection

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Expression of outer surface proteins A and C of Borrelia burgdorferi in Ixodes ricinus ticks removed from humans

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The Treponema denticola FhbB Protein Is a Dominant Early Antigen That Elicits FhbB Variant-Specific Antibodies That Block Factor H Binding and Cleavage by Dentilisin

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Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vector

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Disulfide-mediated oligomer formation in Borrelia burgdorferi outer surface protein C, a critical virulence factor and potential Lyme disease vaccine candidate

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Structure-based Design of a Second-generation Lyme Disease Vaccine Based on a C-terminal Fragment of Borrelia burgdorferi OspA

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inferred from DOI database lookup

Identifiers

10.1016/J.VACCINE.2017.04.079

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28479174%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

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9 June 2020

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