(Q40226041)

English

Clozapine functions through the prefrontal cortex serotonin 1A receptor to heighten neuronal activity via calmodulin kinase II-NMDA receptor interactions.

scientific article published on 15 December 2011

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scholarly article

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15 January 2020

Clozapine functions through the prefrontal cortex serotonin 1A receptor to heighten neuronal activity via calmodulin kinase II-NMDA receptor interactions (English)

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15 January 2020

Efrain C Azmitia

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15 January 2020

Lorenz S. Neuwirth

6

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15 January 2020

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Sudarshana Purkayastha

1

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15 January 2020

Jason Ford

2

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15 January 2020

Baishali Kanjilal

3

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15 January 2020

Souleymane Diallo

4

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15 January 2020

Joseph Del Rosario Inigo

5

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15 January 2020

Abdeslem El Idrissi

7

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15 January 2020

Zaghloul Ahmed

8

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15 January 2020

Andrzej Wieraszko

9

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15 January 2020

Probal Banerjee

11

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15 January 2020

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15 December 2011

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15 January 2020

Journal of Neurochemistry

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15 January 2020

120

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15 January 2020

3

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15 January 2020

396-407

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15 January 2020

Interaction between N-methyl-D-aspartic acid receptors and D1 dopamine receptors: an important mechanism for brain plasticity

1 reference

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22 September 2017

Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders

1 reference

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22 September 2017

Stimulation- and palmitoylation-dependent changes in oligomeric conformation of serotonin 5-HT1A receptors

1 reference

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22 September 2017

Identification of a serotonin/glutamate receptor complex implicated in psychosis

1 reference

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22 September 2017

Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling.

1 reference

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22 September 2017

Plasticity of 5-HT 1A receptor-mediated signaling during early postnatal brain development

1 reference

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22 September 2017

WAY-100635 is a potent dopamine D4 receptor agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

22 September 2017

Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action

1 reference

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22 September 2017

Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia

1 reference

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22 September 2017

5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants

1 reference

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22 September 2017

Understanding antipsychotic "atypicality": a clinical and pharmacological moving target

1 reference

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22 September 2017

Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

22 September 2017

Molecular mechanisms of CaMKII activation in neuronal plasticity

1 reference

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22 September 2017

Synaptic plasticity: a molecular memory switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

22 September 2017

The LTP Program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

22 September 2017

A review of MRI findings in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

22 September 2017

The 5-HT1A receptor in schizophrenia: a promising target for novel atypical neuroleptics?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

22 September 2017

5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

22 September 2017

Improving the treatment of schizophrenia: focus on serotonin (5-HT)(1A) receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

22 September 2017

Intracellular modulation of NMDA receptor function by antipsychotic drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

22 September 2017

Mechanisms of typical and atypical antipsychotic drug action in relation to dopamine and NMDA receptor hypofunction hypotheses of schizophrenia

1 reference

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22 September 2017

NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

22 September 2017

Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

22 September 2017

Molecular characterization of antipeptide antibodies against the 5-HT1A receptor: evidence for state-dependent antibody binding

1 reference

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22 September 2017

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1 reference

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22 September 2017

Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

25 September 2017

Hepatocytes from alpha1B-adrenoceptor knockout mice reveal compensatory adrenoceptor subtype substitution

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15 June 2018

Limbic-cortical neuronal damage and the pathophysiology of schizophrenia

1 reference

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15 June 2018

A neonatal ventral hippocampal lesion causes functional deficits in adult prefrontal cortical interneurons

1 reference

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20 August 2018

WAY-100635 has high selectivity for serotonin 5-HT(1A) versus dopamine D(4) receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

20 August 2018

Functional coupling between the prefrontal cortex and dopamine neurons in the ventral tegmental area.

1 reference

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20 August 2018

Strongly reduced number of parvalbumin-immunoreactive projection neurons in the mammillary bodies in schizophrenia: further evidence for limbic neuropathology

1 reference

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20 August 2018

First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients

1 reference

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20 August 2018

Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations

1 reference

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20 August 2018

Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism.

1 reference

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20 August 2018

Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens: role of NR2B and protein kinase A/Src kinases

1 reference

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20 August 2018

Clozapine modulates midbrain dopamine neuron firing via interaction with the NMDA receptor complex

1 reference

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20 August 2018

Regulation of dopamine D1 receptor function by physical interaction with the NMDA receptors.

1 reference

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Schizophrenia subjects show intact success-related neural activation but impaired uncertainty processing during decision-making

1 reference

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20 August 2018

Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits

1 reference

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20 August 2018

Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex.

1 reference

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20 August 2018

Striatal dopamine-NMDA receptor interactions in the modulation of glutamate release in the substantia nigra pars reticulata in vivo: opposite role for D1 and D2 receptors

1 reference

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20 August 2018

Interaction of dopamine D1 and NMDA receptors mediates acute clozapine potentiation of glutamate EPSPs in rat prefrontal cortex

1 reference

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20 August 2018

Epileptiform activity and EPSP-spike potentiation induced in rat hippocampal CA1 slices by repeated high-K(+): involvement of ionotropic glutamate receptors and Ca(2+)/calmodulin-dependent protein kinase II.

1 reference

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20 August 2018

Clozapine, haloperidol, and the D4 antagonist PNU-101387G: in vivo effects on mesocortical, mesolimbic, and nigrostriatal dopamine and serotonin release

1 reference

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20 August 2018

Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl- D-aspartate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

20 August 2018

Clozapine and haloperidol modulate N-methyl-D-aspartate- and non-N-methyl-D-aspartate receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253201

20 August 2018

Amplification of evoked potentials recorded from mouse hippocampal slices by very low repetition rate pulsed magnetic fields

1 reference

https://pubmed.ncbi.nlm.nih.gov/22044428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antisecretory effects of clozapine, a dopamine D4 receptor antagonist, are blocked by the dopamine D1 receptor antagonist, SCH23390

1 reference

https://pubmed.ncbi.nlm.nih.gov/22044428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635

1 reference

https://pubmed.ncbi.nlm.nih.gov/22044428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The silent and selective 5-HT1A antagonist, WAY 100635, produces via an indirect mechanism, a 5-HT2A receptor-mediated behaviour in mice during the day but not at night. Short communication

1 reference

https://pubmed.ncbi.nlm.nih.gov/22044428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/22044428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1471-4159.2011.07565.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22044428%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22044428%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22044428%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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