(Q40240007)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json

human embryonic stem cell

1 March 2020

main subject

hypoxia

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Philip Calder

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Franchesca D Houghton

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

author name string

David R Christensen

1

1 reference

18 September 2017

Philip C Calder

2

1 reference

18 September 2017

Franchesca D Houghton

3

1 reference

18 September 2017

language of work or name

English

0 references

publication date

7 December 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

page(s)

17500

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

1 March 2020

copyright license

start time

1 December 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/srep17500

0 references

cites work

HIF-2α regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element

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The effect of HIF-1α on glucose metabolism, growth and apoptosis of pancreatic cancerous cells

22 September 2017

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Control of glioma cell death and differentiation by PKM2-Oct4 interaction

22 September 2017

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miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma

22 September 2017

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JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.

22 September 2017

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Metabolome and metaboproteome remodeling in nuclear reprogramming

22 September 2017

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Environmental oxygen tension regulates the energy metabolism and self-renewal of human embryonic stem cells

22 September 2017

1 reference

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

22 September 2017

1 reference

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PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

22 September 2017

1 reference

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Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

22 September 2017

1 reference

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Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

22 September 2017

1 reference

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Energy metabolism in nuclear reprogramming

22 September 2017

1 reference

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The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

22 September 2017

1 reference

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Energy metabolism in human pluripotent stem cells and their differentiated counterparts

22 September 2017

1 reference

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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Hypoxic culture maintains self-renewal and enhances embryoid body formation of human embryonic stem cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Generation of Sheffield (Shef) human embryonic stem cell lines using a microdrop culture system.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain

22 September 2017

1 reference

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Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Pyruvate kinase M2 is a phosphotyrosine-binding protein

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Core transcriptional regulatory circuitry in human embryonic stem cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Low O2 tensions and the prevention of differentiation of hES cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Derivation of Embryonic Stem-Cell Lines from Human Blastocysts

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Non-invasive amino acid turnover predicts human embryo developmental capacity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Embryonic stem cell lines derived from human blastocysts

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Glucose transporter GLUT3: ontogeny, targeting, and role in the mouse blastocyst

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Establishment in culture of pluripotential cells from mouse embryos

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Regulation of glucose-transporter gene expression in vitro and in vivo

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Mammalian glucose transporters: structure and molecular regulation.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Primate embryonic stem cells.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

GLUT3 gene expression is critical for embryonic growth, brain development and survival

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Expression of hypoxia-inducible genes in tumor cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Tissue distribution of the human GLUT3 glucose transporter

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteins

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Distribution of GLUT3 glucose transporter protein in human tissues.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Core Pluripotency Factors Directly Regulate Metabolism in Embryonic Stem Cell to Maintain Pluripotency.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Oxygen-regulated expression of GLUT-1, GLUT-3, and VEGF in the mouse blastocyst

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671001

The effect of hypoxia on human trophoblast in culture: morphology, glucose transport and metabolism

20 August 2018

1 reference

12 December 2020

A high glycolytic flux supports the proliferative potential of murine embryonic stem cells

1 reference

12 December 2020

Effect of Hypoxia on 2-Deoxyglucose Uptake and Cell Cycle Regulatory Protein Expression of Mouse Embryonic Stem Cells: Involvement of Ca 2+ /PKC, MAPKs and HIF-1α

1 reference

12 December 2020

Effect of Oxygen Tension on the Amino Acid Utilisation of Human Embryonic Stem Cells

1 reference

12 December 2020

The blood-nerve barrier is rich in glucose transporter

1 reference

12 December 2020

Continuous hypoxic culturing maintains activation of Notch and allows long-term propagation of human embryonic stem cells without spontaneous differentiation

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP17500

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

26639784

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26639784%20AND%20SRC:MED&resulttype=core&format=json