(Q47154700)

9 January 2018

title

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2. (English)

1 reference

9 January 2018

author

Erich Wanker

8

1 reference

9 January 2018

Markus Ralser

9

1 reference

9 January 2018

Barbara G Mlody

Barbara Mlody

4

0 references

Thorsten Cramer

Thorsten Cramer

10

0 references

James Adjaye

11

James Adjaye

1 reference

9 January 2018

Alessandro Prigione

1

Alessandro Prigione

1 reference

9 January 2018

Raul Bukowiecki

6

Raul Bukowiecki

1 reference

9 January 2018

3

Sheila Hoffmann

1 reference

9 January 2018

Nadine Rohwer

2

1 reference

9 January 2018

Katharina Drews

5

1 reference

9 January 2018

Katharina Blümlein

7

1 reference

9 January 2018

publication date

1 February 2014

1 reference

9 January 2018

published in

Stem Cells

1 reference

9 January 2018

volume

32

1 reference

9 January 2018

issue

2

1 reference

9 January 2018

page(s)

364-376

1 reference

9 January 2018

Benchmarking of mutation diagnostics in clinical lung cancer specimens

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Somatic coding mutations in human induced pluripotent stem cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Copy number variation and selection during reprogramming to pluripotency

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Genomic instability in induced stem cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Mitochondrial rejuvenation after induced pluripotency

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Reprogramming of human primary somatic cells by OCT4 and chemical compounds

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Mitochondrial DNA variant discovery and evaluation in human Cardiomyopathies through next-generation sequencing

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Epigenetic memory in induced pluripotent stem cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Targeting metabolic transformation for cancer therapy.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Regulatory crosstalk of the metabolic network

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Vitamin C enhances the generation of mouse and human induced pluripotent stem cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Prevalence of mitochondrial DNA disease in adults

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Mitochondrial DNA deletions induce the adenosine monophosphate-activated protein kinase energy stress pathway and result in decreased secretion of some proteins

23 May 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

23 May 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Mitochondrial DNA mutations in human cancer

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Mitochondrial mutations in cancer

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Mitochondrial DNA mutations in human disease

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Mitochondria, oxidants, and aging

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

mtDNA mutations increase tumorigenicity in prostate cancer

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Mitochondrial respiratory-chain diseases

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Bioenergetic consequences of accumulating the common 4977-bp mitochondrial DNA deletion

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Mitochondrial DNA sequence variation in human evolution and disease.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Sequence and organization of the human mitochondrial genome

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Replication and Transcription of Vertebrate Mitochondrial DNA

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Rapid evolution of animal mitochondrial DNA

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Metabolic reconfiguration precedes transcriptional regulation in the antioxidant response.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

15 August 2018

1 reference

On the Origin of Cancer Cells

21 January 2018

1 reference

Otto Warburg's contributions to current concepts of cancer metabolism

21 January 2018

1 reference

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

21 January 2018

1 reference

Regulation of cancer cell metabolism

21 January 2018

1 reference

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

21 January 2018

1 reference

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

1 reference

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

21 January 2018

1 reference

Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells

21 January 2018

1 reference

Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer

21 January 2018

1 reference

Hypoxia-inducible factors in physiology and medicine

21 January 2018

1 reference

The growing complexity of HIF-1α's role in tumorigenesis: DNA repair and beyond.

21 January 2018

1 reference

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

1 reference

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

21 January 2018

1 reference

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

21 January 2018

1 reference

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity

21 January 2018

1 reference

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

21 January 2018

1 reference

The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

21 January 2018

1 reference

Energy metabolism in human pluripotent stem cells and their differentiated counterparts

21 January 2018

1 reference

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.

21 January 2018

1 reference

Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal

21 January 2018

1 reference

Metabolic plasticity in stem cell homeostasis and differentiation

21 January 2018

1 reference

Mitochondrial regulation in pluripotent stem cells

21 January 2018

1 reference

Mitochondrial function in pluripotent stem cells and cellular reprogramming

21 January 2018

1 reference

Low O2 tensions and the prevention of differentiation of hES cells

21 January 2018

1 reference

Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions

21 January 2018

1 reference

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

21 January 2018

1 reference

Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.

21 January 2018

1 reference

Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations

21 January 2018

1 reference

Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network

21 January 2018

1 reference

Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells.

21 January 2018

1 reference

Efficient feeder-free episomal reprogramming with small molecules

21 January 2018

1 reference

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

21 January 2018

1 reference

Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin

21 January 2018

1 reference

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

21 January 2018

1 reference

HIF induces human embryonic stem cell markers in cancer cells.

21 January 2018

1 reference

Induced pluripotent stem cells: past, present, and future

21 January 2018

1 reference

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.

21 January 2018

1 reference

Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

21 January 2018

1 reference

Origins and implications of pluripotent stem cell variability and heterogeneity

21 January 2018

1 reference

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

21 January 2018

1 reference

UCP2 inhibits ROS-mediated apoptosis in A549 under hypoxic conditions

21 January 2018

1 reference

Hypoxia induces re-entry of committed cells into pluripotency

21 January 2018

1 reference

A molecular roadmap of reprogramming somatic cells into iPS cells

21 January 2018

1 reference

MYC-induced cancer cell energy metabolism and therapeutic opportunities

21 January 2018

1 reference

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

21 January 2018

1 reference

Krüppel-like factor 4 (KLF4) activates the transcription of the gene for the platelet isoform of phosphofructokinase (PFKP) in breast cancer

21 January 2018

1 reference

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

21 January 2018

1 reference

SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta

21 January 2018

1 reference

Integration of external signaling pathways with the core transcriptional network in embryonic stem cells

21 January 2018

1 reference

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

21 January 2018

1 reference

Cancer: Sacrifice for survival.

21 January 2018

1 reference

Metabolic oxidation regulates embryonic stem cell differentiation

21 January 2018

1 reference

Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts

21 January 2018

1 reference

Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730046

Reproducible quantitative PCR of mitochondrial and nuclear DNA copy number using the LightCycler

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24123565

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24123565

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/STEM.1552

1 reference

9 January 2018

PMC publication ID

5730046

1 reference

9 January 2018

PubMed publication ID

24123565

1 reference

9 January 2018