(Q38060522)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160373%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

review article

1 reference

title

The growing complexity of HIF-1α's role in tumorigenesis: DNA repair and beyond (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160373%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160373%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Thorsten Cramer

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160373%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

author name string

N Rohwer

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160373%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

S Kempa

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160373%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

language of work or name

English

0 references

publication date

19 November 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160373%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160373%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

volume

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160373%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

issue

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160373%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

page(s)

3569-3576

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160373%20AND%20SRC:MED&resulttype=core&format=json

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

18 February 2020

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1 reference

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Purification and characterization of hypoxia-inducible factor 1

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

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The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

21 January 2018

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Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

21 January 2018

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Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

21 January 2018

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Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex

21 January 2018

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

21 January 2018

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Reciprocal influence of the p53 and the hypoxic pathways

21 January 2018

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HIF-1: upstream and downstream of cancer metabolism

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21 January 2018

Biology of HIF-1alpha

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Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways

21 January 2018

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 January 2018

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Hallmarks of Cancer: The Next Generation

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Pericytes and vessel maturation during tumor angiogenesis and metastasis

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Tumor hypoxia and malignant progression.

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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Oxygen sensing, homeostasis, and disease

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The hypoxic response of tumors is dependent on their microenvironment.

21 January 2018

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Role of hypoxia-inducible transcription factor 1alpha for progression and chemosensitivity of murine hepatocellular carcinoma

21 January 2018

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Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

21 January 2018

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Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas

21 January 2018

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Hypoxia-associated markers in gastric carcinogenesis and HIF-2alpha in gastric and gastro-oesophageal cancer prognosis

21 January 2018

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Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

21 January 2018

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HIF-2alpha expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia.

21 January 2018

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

21 January 2018

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Expression of hypoxia-inducible factor 1: mechanisms and consequences

21 January 2018

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The AMP-activated protein kinase cascade--a unifying system for energy control

21 January 2018

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

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Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F]fluoromisonidazole and [18F]fluorodeoxyglucose positron emission tomography imaging

21 January 2018

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Rethinking the Warburg effect with Myc micromanaging glutamine metabolism

21 January 2018

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Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation

21 January 2018

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Targeting cancer metabolism: a therapeutic window opens

21 January 2018

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Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB

21 January 2018

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HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase

21 January 2018

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THE METABOLISM OF TUMORS IN THE BODY

21 January 2018

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L-glutamine: a major substrate for tumor cells in vivo?

21 January 2018

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Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)

21 January 2018

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Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival

21 January 2018

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Deregulated MYC expression induces dependence upon AMPK-related kinase 5.

21 January 2018

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The DNA damage response and cancer therapy

21 January 2018

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Poly(ADP-ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

21 January 2018

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BRCA1 and its toolbox for the maintenance of genome integrity

21 January 2018

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The DNA Damage Response: Making It Safe to Play with Knives

21 January 2018

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Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression

21 January 2018

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Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

21 January 2018

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Tumor regrowth after irradiation; an experimental approach

21 January 2018

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Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia

21 January 2018

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Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities.

21 January 2018

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Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia

21 January 2018

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Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

21 January 2018

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Checkpoint control and cancer.

21 January 2018

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Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.

21 January 2018

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HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

21 January 2018

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BRCA1 plays a role in the hypoxic response by regulating HIF-1alpha stability and by modulating vascular endothelial growth factor expression

21 January 2018

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Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts

21 January 2018

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mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α

21 January 2018

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Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

21 January 2018

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PARP-1 modulates deferoxamine-induced HIF-1alpha accumulation through the regulation of nitric oxide and oxidative stress

21 January 2018

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Telomeres and telomerase in cancer

21 January 2018

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HIF-1-mediated activation of telomerase in cervical cancer cells

21 January 2018

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Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT).

21 January 2018

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RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1alpha as critical for telomerase function in murine embryonic stem cells

21 January 2018

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The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: a review

21 January 2018

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The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide

21 January 2018

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Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment

21 January 2018

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A decade of exploring the cancer epigenome - biological and translational implications

21 January 2018

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More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

21 January 2018

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Chromatin as an oxygen sensor and active player in the hypoxia response.

21 January 2018

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Roles of coactivators in hypoxic induction of the erythropoietin gene

21 January 2018

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PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia.

21 January 2018

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Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.

21 January 2018

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Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.

21 January 2018

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Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

21 January 2018

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Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1.

21 January 2018

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Targeted therapy for cancer using PARP inhibitors

21 January 2018

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HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

21 January 2018

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HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

21 January 2018

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Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells

21 January 2018

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Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

21 January 2018

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Hypoxia and metastasis in breast cancer

21 January 2018

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Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease

21 January 2018

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Hypoxia and energetic tumour metabolism

21 January 2018

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Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much?

21 January 2018

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K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

21 January 2018

1 reference

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Variability of immunohistochemical reactivity on stored paraffin slides

21 January 2018

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Hypoxia inducible factor pathways as targets for functional foods

21 January 2018

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n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway

21 January 2018

1 reference

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Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells

21 January 2018

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Epigallocatechin gallate inhibits HIF-1alpha degradation in prostate cancer cells

21 January 2018

1 reference

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Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells

21 January 2018

1 reference

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Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism

21 January 2018

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Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

21 January 2018

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Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases

21 January 2018

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Disparate effects of simvastatin on angiogenesis during hypoxia and inflammation

21 January 2018

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HIF-1alpha determines the metastatic potential of gastric cancer cells

21 January 2018

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Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

21 January 2018

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Inhibition of Poly(ADP-Ribose) Polymerase Modulates Tumor-Related Gene Expression, Including Hypoxia-Inducible Factor-1 Activation, during Skin Carcinogenesis

21 January 2018

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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

21 January 2018

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Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

31 March 2020

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The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia

31 March 2020

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Inducible repair and the two forms of tumour hypoxia--time for a paradigm shift

31 March 2020

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Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation

31 March 2020

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High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer

31 March 2020

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Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression

31 March 2020

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Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms

31 March 2020

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Loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer

31 March 2020

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