(Q36688644)

15 August 2017

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title

Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression (English)

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15 August 2017

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4

Adrian L Harris

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15 August 2017

L Eric Huang

1

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15 August 2017

Ranjit S Bindra

series ordinal

2

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15 August 2017

Peter M Glazer

series ordinal

3

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15 August 2017

publication date

20 December 2006

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Journal of Molecular Medicine

15 August 2017

published in

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15 August 2017

volume

85

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15 August 2017

issue

2

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15 August 2017

page(s)

139-148

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Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis

15 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00109-006-0133-6

Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-006-0133-6

Genetic instability: the dark side of the hypoxic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-006-0133-6

Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-006-0133-6

Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma

21 January 2018

1 reference

12 December 2020

ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation

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12 December 2020

In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays.

1 reference

12 December 2020

A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs

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12 December 2020

An essential role for p300/CBP in the cellular response to hypoxia

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12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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12 December 2020

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

12 December 2020

RORA, a large common fragile site gene, is involved in cellular stress response

1 reference

12 December 2020

Microenvironmental influences on mutagenesis in mammary epithelial cells.

1 reference

12 December 2020

Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulation of MSH2 expression

1 reference

12 December 2020

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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12 December 2020

Cancer susceptibility and the functions of BRCA1 and BRCA2

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12 December 2020

The E2F transcriptional network: old acquaintances with new faces

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12 December 2020

Pathophysiology of ischaemia reperfusion injury: central role of the neutrophil

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12 December 2020

Effect of transient hypoxia on sensitivity to doxorubicin in human and murine cell lines

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12 December 2020

Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene

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12 December 2020

Common fragile sites.

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12 December 2020

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

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12 December 2020

Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.

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12 December 2020

A conserved family of prolyl-4-hydroxylases that modify HIF

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12 December 2020

Genetic instability induced by the tumor microenvironment.

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12 December 2020

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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12 December 2020

Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation

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12 December 2020

Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells

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12 December 2020

Human rad21 gene, hHR21(SP), is downregulated by hypoxia in human tumor cells

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells

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12 December 2020

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

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12 December 2020

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression

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12 December 2020

Mammalian DNA mismatch repair

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12 December 2020

Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures

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12 December 2020

Hypoxia-inducible factor and its biomedical relevance

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12 December 2020

Dynamic balancing of the dual nature of HIF-1alpha for cell survival

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12 December 2020

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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12 December 2020

The E2F family: specific functions and overlapping interests

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12 December 2020

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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12 December 2020

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

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12 December 2020

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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12 December 2020

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

1 reference

12 December 2020

Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes

1 reference

12 December 2020

Detection of S-phase overreplication following chronic hypoxia using a monoclonal anti-BrdUrd

1 reference

12 December 2020

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

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12 December 2020

HIF-1 and tumour radiosensitivity

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12 December 2020

Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

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12 December 2020

Hypoxia links ATR and p53 through replication arrest

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12 December 2020

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

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12 December 2020

E2Fs link the control of G1/S and G2/M transcription

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12 December 2020

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

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12 December 2020

Emerging roles for E2F: Beyond the G1/S transition and DNA replication

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12 December 2020

Rules for making human tumor cells

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12 December 2020

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

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12 December 2020

Targeting HIF-1 for cancer therapy

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12 December 2020

Hypoxia--a key regulatory factor in tumour growth

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12 December 2020

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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12 December 2020

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

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12 December 2020

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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12 December 2020

Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells

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12 December 2020

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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12 December 2020

Mutagenesis induced by the tumor microenvironment

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12 December 2020

Cancer-susceptibility genes. Gatekeepers and caretakers

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12 December 2020

Alterations in DNA repair gene expression under hypoxia: elucidating the mechanisms of hypoxia-induced genetic instability

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12 December 2020

Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells

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12 December 2020

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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12 December 2020

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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12 December 2020

Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.

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12 December 2020

DNA damage and repair

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12 December 2020

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

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12 December 2020

Instability and decay of the primary structure of DNA

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12 December 2020

Common fragile sites and cancer (review)

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12 December 2020

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.

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12 December 2020

Hypoxia-induced energy stress regulates mRNA translation and cell growth

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12 December 2020

Common fragile sites and cancer: targeted cloning by insertional mutagenesis

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12 December 2020

Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH

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12 December 2020

Regulation of angiogenesis by hypoxia: role of the HIF system

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12 December 2020

HIF-1 and tumor progression: pathophysiology and therapeutics

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12 December 2020

Hypoxia and defective apoptosis drive genomic instability and tumorigenesis

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12 December 2020

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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12 December 2020

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

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12 December 2020

Cancer genes and the pathways they control

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12 December 2020

Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity

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12 December 2020

Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells

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12 December 2020

10.1007/S00109-006-0133-6

Identifiers

DOI

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15 August 2017

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