(Q37914865)

English

Oxygen sensing, homeostasis, and disease

scientific article published on August 2011

In more languages

edit

Statements

instance of

scholarly article

1 reference

stated in

Europe PubMed Central

25 August 2017

1 reference

Europe PubMed Central

title

Oxygen sensing, homeostasis, and disease (English)

1 reference

stated in

Europe PubMed Central

25 August 2017

1 reference

1 reference

1

Gregg L Semenza

1 reference

stated in

Europe PubMed Central

PubMed ID

21830968

retrieved

25 August 2017

language of work or name

English

0 references

publication date

1 August 2011

1 reference

stated in

Europe PubMed Central

25 August 2017

The New England Journal of Medicine

1 reference

stated in

Europe PubMed Central

25 August 2017

365

1 reference

stated in

Europe PubMed Central

25 August 2017

537-547

1 reference

stated in

Europe PubMed Central

25 August 2017

6

1 reference

stated in

Europe PubMed Central

25 August 2017

Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Regulation of bone marrow-derived vascular progenitor cell mobilization and maintenance

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Acute oxygen-sensing mechanisms

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Targeting hypoxia cell signaling for cancer therapy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Two routes to functional adaptation: Tibetan and Andean high-altitude natives

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Biology of hypoxia-inducible factor-2alpha in development and disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Isolation and characterization of genomic and cDNA clones of human erythropoietin

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Regulation of DNA repair in hypoxic cancer cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Cloning and expression of the human erythropoietin gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Sequencing of 50 human exomes reveals adaptation to high altitude

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia. 5. Hypoxia and hematopoiesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia: a key regulator of angiogenesis in cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Erythropoietin in combination of tissue plasminogen activator exacerbates brain hemorrhage when treatment is initiated 6 hours after stroke

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

HIF-1alpha dysfunction in diabetes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Genetic evidence for high-altitude adaptation in Tibet

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Oxidative stress in severe pulmonary hypertension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Vascular growth in ischemic limbs: a review of mechanisms and possible therapeutic stimulation.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Myocardial transfection of hypoxia inducible factor-1alpha via an adenoviral vector during coronary artery bypass grafting. - A multicenter phase I and safety study -.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Effects of hypoxia on tumor metabolism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Regulation of tumor pH and the role of carbonic anhydrase 9.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Tumor angiogenesis: therapeutic implications

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Metastasis and stem cell pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia and adaptive landscapes in the evolution of carcinogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Erythropoietin therapy for acute stroke is both safe and beneficial

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia and inflammation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Therapeutic manipulation of the HIF hydroxylases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Angiogenesis in life, disease and medicine

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Lower mortality from coronary heart disease and stroke at higher altitudes in Switzerland.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia, gene expression, and metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Mitochondrial reactive oxygen species regulate hypoxic signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Vascular complications in Chuvash polycythemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Early expression of angiogenesis factors in acute myocardial ischemia and infarction

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Increased endogenous angiogenic response and hypoxia-inducible factor-1alpha in human critical limb ischemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Recombinant human erythropoietin in the treatment of acute ischemic stroke

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Tumor hypoxia and malignant progression.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia-driven selection of the metastatic phenotype

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Bone marrow-derived cells do not incorporate into the adult growing vasculature.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1056/NEJMRA1011165

Identifiers

DOI

10.1056/NEJMRA1011165

1 reference

stated in

Europe PubMed Central

25 August 2017

1 reference

Europe PubMed Central

PubMed ID

21830968

retrieved

25 August 2017

(Q37914865)

Oxygen sensing, homeostasis, and disease

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)