(Q37084096)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18273037%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

review article

1 reference

title

Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18273037%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18273037%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

author name string

Richard P Hill

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18273037%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

language of work or name

English

0 references

publication date

1 March 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18273037%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18273037%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18273037%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

page(s)

180-192

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18273037%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18273037%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrc2344

2 January 2020

exact match

0 references

cites work

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

1 reference

Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

31 March 2020

1 reference

Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies

31 March 2020

1 reference

31 March 2020

Hypoxia and metastasis

1 reference

Hypoxia in cancer: significance and impact on clinical outcome

31 March 2020

1 reference

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

31 March 2020

1 reference

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

31 March 2020

1 reference

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

31 March 2020

1 reference

Evaluation of HIF-1 inhibitors as anticancer agents

31 March 2020

1 reference

HIF-1 as a target for drug development

31 March 2020

1 reference

Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment

31 March 2020

1 reference

Hypoxia--a key regulatory factor in tumour growth

31 March 2020

1 reference

Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers

31 March 2020

1 reference

The hypoxic proteome is influenced by gene-specific changes in mRNA translation

31 March 2020

1 reference

Control of the hypoxic response through regulation of mRNA translation.

31 March 2020

1 reference

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

31 March 2020

1 reference

Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia.

31 March 2020

1 reference

Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment

31 March 2020

1 reference

Regulation of DNA repair in hypoxic cancer cells

31 March 2020

1 reference

Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression

31 March 2020

1 reference

Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis

31 March 2020

1 reference

Phosphorylation of histone H2AX as a measure of radiosensitivity

31 March 2020

1 reference

Estimating DNA repair by sequential evaluation of head and neck tumor radiation sensitivity using the comet assay.

31 March 2020

1 reference

The prediction of human tumor radiosensitivity in situ: an approach using chromosome aberrations detected by fluorescence in situ hybridization

31 March 2020

1 reference

Radiation-induced DNA damage in tumors and normal tissues. III. Oxygen dependence of the formation of strand breaks and DNA-protein crosslinks

31 March 2020

1 reference

Chemical radiosensitizers for use in radiotherapy

31 March 2020

1 reference

Hypoxic radiosensitization: adored and ignored

31 March 2020

1 reference

Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies.

31 March 2020

1 reference

Drug penetration in solid tumours

31 March 2020

1 reference

Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity

31 March 2020

1 reference

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

31 March 2020

1 reference

Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies

31 March 2020

1 reference

Cell cycle progression and radiation survival following prolonged hypoxia and re-oxygenation.

31 March 2020

1 reference

Increased radiosensitivity with chronic hypoxia in four human tumor cell lines

31 March 2020

1 reference

The in vitro sensitivity of chronically hypoxic EMT6/SF cells to X-radiation and hypoxic cell radiosensitizers

31 March 2020

1 reference

Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells

31 March 2020

1 reference

Effects of reoxygenation on cells from hypoxic regions of solid tumors: anticancer drug sensitivity and metastatic potential.

31 March 2020

1 reference

Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma

31 March 2020

1 reference

Microenvironmental influences on mutagenesis in mammary epithelial cells.

31 March 2020

1 reference

Effect of transient hypoxia on sensitivity to doxorubicin in human and murine cell lines

31 March 2020

1 reference

Microenvironment-induced cancer metastasis

31 March 2020

1 reference

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

31 March 2020

1 reference

Hypoxia, gene expression, and metastasis

31 March 2020

1 reference

Preparing the "soil": the premetastatic niche

31 March 2020

1 reference

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

31 March 2020

1 reference

Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis

31 March 2020

1 reference

Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion

31 March 2020

1 reference

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

31 March 2020

1 reference

Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations

31 March 2020

1 reference

Effects of hypoxia on tumor metabolism

31 March 2020

1 reference

Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species

31 March 2020

1 reference

Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia.

31 March 2020

1 reference

Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner

31 March 2020

1 reference

DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response

31 March 2020

1 reference

ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation

31 March 2020

1 reference

Hypoxic suppression of the cell cycle gene CDC25A in tumor cells

31 March 2020

1 reference

Effect of dietary vitamin E on spontaneous or nitric oxide donor-induced mutations in a mouse tumor model

31 March 2020

1 reference

Growth of V79 cells as xenograft tumors promotes multicellular resistance but does not increase spontaneous or radiation-induced mutant frequency

31 March 2020

1 reference

The mechanism of non-homologous end-joining: a synopsis of synapsis

31 March 2020

1 reference

Chromosomal stability and the DNA double-stranded break connection

31 March 2020

1 reference

DNA double-strand break repair: from mechanistic understanding to cancer treatment

31 March 2020

1 reference

The life and death of DNA-PK.

31 March 2020

1 reference

Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.

31 March 2020

1 reference

Genetic steps of mammalian homologous repair with distinct mutagenic consequences

31 March 2020

1 reference

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

31 March 2020

1 reference

Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

31 March 2020

1 reference

Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.

31 March 2020

1 reference

Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia

31 March 2020

1 reference

Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status.

31 March 2020

1 reference

ERCC1/ERCC4 5'-endonuclease activity as a determinant of hypoxic cell radiosensitivity

31 March 2020

1 reference

Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells

31 March 2020

1 reference

Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells

31 March 2020

1 reference

Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis

31 March 2020

1 reference

Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells

31 March 2020

1 reference

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression

31 March 2020

1 reference

Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells

31 March 2020

1 reference

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

31 March 2020

1 reference

Co-repression of mismatch repair gene expression by hypoxia in cancer cells: role of the Myc/Max network

31 March 2020

1 reference

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

31 March 2020

1 reference

Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation

31 March 2020

1 reference

Hypoxia-induced energy stress regulates mRNA translation and cell growth

31 March 2020

1 reference

RORA, a large common fragile site gene, is involved in cellular stress response.

31 March 2020

1 reference

Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons

31 March 2020

1 reference

A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs

31 March 2020

1 reference

HIF-1-mediated activation of telomerase in cervical cancer cells

31 March 2020

1 reference

Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms

31 March 2020

1 reference

Rapid effects of acute anoxia on spindle kinetochore interactions activate the mitotic spindle checkpoint.

31 March 2020

1 reference

Hypoxia-induced and stress-specific changes in chromatin structure and function

31 March 2020

1 reference

Genetic susceptibility and oxidative stress in prostate cancer: integrated model with implications for prevention

31 March 2020

1 reference

HIF-dependent antitumorigenic effect of antioxidants in vivo

31 March 2020

1 reference

Exploiting tumour hypoxia in cancer treatment

31 March 2020

1 reference

Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells

31 March 2020

1 reference

Radiation and new molecular agents part I: targeting ATM-ATR checkpoints, DNA repair, and the proteasome

31 March 2020

1 reference

DNA-binding properties of poly(ADP-ribose) polymerase: a target for anticancer therapy

31 March 2020

1 reference

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

31 March 2020

1 reference

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

31 March 2020

1 reference

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

31 March 2020

1 reference