(Q37054884)

18 August 2017

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title

Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation (English)

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18 August 2017

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L E Huang

1

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18 August 2017

11 January 2008

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Cell Death & Differentiation

18 August 2017

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18 August 2017

15

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18 August 2017

672-677

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18 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402302

18 August 2017

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cites work

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Hypoxia--a key regulatory factor in tumour growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

HIF-1 as a target for drug development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Purification and characterization of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

PAS is a dimerization domain common to Drosophila period and several transcription factors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Proline hydroxylation and gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

An essential role for p300/CBP in the cellular response to hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

c-Myc target genes involved in cell growth, apoptosis, and metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

The Myc/Max/Mad network and the transcriptional control of cell behavior

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Transcriptional regulation and transformation by Myc proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Negative regulation of the mammalian UV response by Myc through association with Miz-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Hypoxic suppression of the cell cycle gene CDC25A in tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Acute postnatal ablation of Hif-2alpha results in anemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Global mapping of c-Myc binding sites and target gene networks in human B cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Genetic instability: the dark side of the hypoxic response.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402302

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402302

1 reference

PubMed ID

18188166

Dimensions Publication ID

18 August 2017

0 references

1 reference

PubMed ID

18188166