(Q35550217)

8 August 2017

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title

HIF-1 as a target for drug development (English)

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8 August 2017

Amato Giaccia

1

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8 August 2017

Bronwyn G Siim

series ordinal

2

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8 August 2017

Randall S Johnson

series ordinal

3

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8 August 2017

1 October 2003

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Nature Reviews Drug Discovery

8 August 2017

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8 August 2017

2

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8 August 2017

10

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8 August 2017

803-811

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https://scigraph.springernature.com/pub.10.1038/nrd1199

8 August 2017

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A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

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Molecular mechanisms of vasculogenesis and embryonic angiogenesis

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Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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Regulation of the hypoxia-inducible factor-1 alpha. ARNT is not necessary for hypoxic induction of HIF-1 alpha in the nucleus

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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

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Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

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How the cyclin became a cyclin: regulated proteolysis in the cell cycle

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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A conserved family of prolyl-4-hydroxylases that modify HIF

31 March 2020

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

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Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

31 March 2020

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

31 March 2020

1 reference

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

31 March 2020

1 reference

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

31 March 2020

1 reference

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

31 March 2020

1 reference

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

31 March 2020

1 reference

A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.

31 March 2020

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Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

31 March 2020

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Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

31 March 2020

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Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

31 March 2020

1 reference

Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions

31 March 2020

1 reference

Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia

31 March 2020

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Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

31 March 2020

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Signal transduction to hypoxia-inducible factor 1

31 March 2020

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

31 March 2020

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Hypoxia--a key regulatory factor in tumour growth

31 March 2020

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

31 March 2020

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

31 March 2020

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

31 March 2020

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Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

31 March 2020

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Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy

31 March 2020

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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

31 March 2020

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A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts

31 March 2020

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Hsp90 inhibitors as novel cancer chemotherapeutic agents

31 March 2020

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Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein Shc in endothelial cells

31 March 2020

1 reference

Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

31 March 2020

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Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways

31 March 2020

1 reference

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

31 March 2020

1 reference

Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.

31 March 2020

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Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

31 March 2020

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p53 inhibits hypoxia-inducible factor-stimulated transcription

31 March 2020

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TOR signalling and control of cell growth

31 March 2020

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Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

31 March 2020

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MAP kinases and hypoxia in the control of VEGF expression

31 March 2020

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MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.

31 March 2020

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Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

31 March 2020

1 reference

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

31 March 2020

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

31 March 2020

1 reference

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

31 March 2020

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Phase I clinical trial of 7-cyanoquinocarcinol (DX-52-1) in adult patients with refractory solid malignancies

31 March 2020

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2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate

31 March 2020

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2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

31 March 2020

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Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1alpha protein

31 March 2020

1 reference

YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.

31 March 2020

1 reference

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

31 March 2020

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HIF-1alpha is essential for myeloid cell-mediated inflammation

31 March 2020

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Harnessing the response to tissue hypoxia: HIF-1 alpha and therapeutic angiogenesis

31 March 2020

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Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

31 March 2020

1 reference

Hypoxia up-regulates expression of peroxisome proliferator-activated receptor gamma angiopoietin-related gene (PGAR) in cardiomyocytes: role of hypoxia inducible factor 1alpha

31 March 2020

1 reference

Gene expression profiles in human cardiac cells subjected to hypoxia or expressing a hybrid form of HIF-1 alpha.

31 March 2020

1 reference

Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction

31 March 2020

1 reference

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1199

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Dimensions Publication ID

8 August 2017

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