(Q40754086)

English

Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.

scientific article published on 28 January 2002

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Europe PubMed Central

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6 December 2019

Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11815624%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

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Julian Aragones Lopez

3

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6 December 2019

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6 December 2019

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Miguel Alvarez-Tejado

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6 December 2019

Arántzazu Alfranca

2

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6 December 2019

Alicia Vara

4

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6 December 2019

Manuel O Landázuri

5

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6 December 2019

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28 January 2002

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6 December 2019

Journal of Biological Chemistry

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6 December 2019

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6 December 2019

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6 December 2019

13508-13517

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6 December 2019

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Angiogenesis: how a tumor adapts to hypoxia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Rac1 activity is required for the activation of hypoxia-inducible factor 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Negative regulation of the forkhead transcription factor FKHR by Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Signal transduction pathways that regulate eukaryotic protein synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200017200

21 January 2018

Identifiers

10.1074/JBC.M200017200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11815624%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11815624%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

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