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HIF-1: upstream and downstream of cancer metabolism
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Europe PubMed Central
title
HIF-1: upstream and downstream of cancer metabolism
(English)
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author
Gregg L. Semenza
series ordinal
1
object named as
Gregg L Semenza
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language of work or name
English
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publication date
February 2010
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published in
Current Opinion in Genetics & Development
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volume
20
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issue
1
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page(s)
51-6
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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
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mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
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Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma
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HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.
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Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.
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HIF-dependent antitumorigenic effect of antioxidants in vivo
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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
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The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.
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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
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12 December 2020
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Identifiers
DOI
10.1016/J.GDE.2009.10.009
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1038416
OpenCitations bibliographic resource ID
1038416
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1038416
PMCID
2822127
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1038416
PubMed ID
19942427
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1038416
ResearchGate publication ID
40035581
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