(Q37826009)

23 August 2017

1 reference

title

Poly(ADP-ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic (English)

1 reference

23 August 2017

Timothy A Yap

1

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23 August 2017

Shahneen K Sandhu

series ordinal

2

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23 August 2017

Craig P Carden

series ordinal

3

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23 August 2017

Johann S de Bono

series ordinal

4

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23 August 2017

language of work or name

English

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publication date

4 January 2011

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23 August 2017

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23 August 2017

61

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23 August 2017

31-49

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23 August 2017

1

1 reference

The concept of synthetic lethality in the context of anticancer therapy

23 August 2017

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The future of cytotoxic therapy: selective cytotoxicity based on biology is the key

21 January 2018

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Global synthetic-lethality analysis and yeast functional profiling

21 January 2018

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Utilizing RNA interference to enhance cancer drug discovery

21 January 2018

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https://api.crossref.org/works/10.3322%2FCAAC.20095

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

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https://api.crossref.org/works/10.3322%2FCAAC.20095

Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

21 January 2018

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https://api.crossref.org/works/10.3322%2FCAAC.20095

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

21 January 2018

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

21 January 2018

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https://api.crossref.org/works/10.3322%2FCAAC.20095

Genome maintenance mechanisms for preventing cancer

21 January 2018

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https://api.crossref.org/works/10.3322%2FCAAC.20095

Coordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Base excision repair of oxidative DNA damage and association with cancer and aging

21 January 2018

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https://api.crossref.org/works/10.3322%2FCAAC.20095

Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity

21 January 2018

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https://api.crossref.org/works/10.3322%2FCAAC.20095

Cancer in xeroderma pigmentosum and related disorders of DNA repair

21 January 2018

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https://api.crossref.org/works/10.3322%2FCAAC.20095

Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancer phenotypes

21 January 2018

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https://api.crossref.org/works/10.3322%2FCAAC.20095

The multifaceted mismatch-repair system

21 January 2018

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https://api.crossref.org/works/10.3322%2FCAAC.20095

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

21 January 2018

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https://api.crossref.org/works/10.3322%2FCAAC.20095

BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Susceptibility pathways in Fanconi's anemia and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Cancer susceptibility and the functions of BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

DNA recombination: the replication connection.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Homologous recombination in cancer development, treatment and development of drug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

A phase IB trial of intravenous INO-1001 plus oral temozolomide in subjects with unresectable stage-III or IV melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Envisioning the future of early anticancer drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Hallmarks of 'BRCAness' in sporadic cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Basal-like breast cancer and the BRCA1 phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Platinum-based chemotherapy in triple-negative breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Treatment outcomes and clinicopathologic characteristics of triple-negative breast cancer patients who received platinum-containing chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Triple negative tumours: a critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Leukemia and preleukemia in Fanconi anemia patients. A review of the literature and report of the International Fanconi Anemia Registry

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Fanconi's anemia and malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Mantle cell lymphoma is characterized by inactivation of the ATM gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Cancer risks and mortality in heterozygous ATM mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Essential role for nuclear PTEN in maintaining chromosomal integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

PTEN: a new guardian of the genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Promising novel therapies for the treatment of endometrial cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Repeated observation of breast tumor subtypes in independent gene expression data sets

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Gene-Expression Profiles in Hereditary Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Resistance to therapy caused by intragenic deletion in BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Improved survival in women with BRCA-associated ovarian carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

gammaH2AX expression in tumors exposed to cisplatin and fractionated irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Monitoring drug-induced gammaH2AX as a pharmacodynamic biomarker in individual circulating tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Can molecular biomarker-based patient selection in Phase I trials accelerate anticancer drug development?

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

BRCA1 promoter methylation is associated with increased mortality among women with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Association of circulating tumor cells with serum tumor-related methylated DNA in peripheral blood of melanoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

DNA repair pathways as targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Poly(ADP-ribose) polymerase inhibitors in cancer treatment: a clinical perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Proteasome function is required for DNA damage response and fanconi anemia pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Efficient Deletion of NormalBrca2-Deficient Intestinal Epithelium by Poly(ADP-Ribose) Polymerase Inhibition Models Potential Prophylactic Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

PTEN mutations are common in sporadic microsatellite stable colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

Germ-Line Mutations in Mismatch Repair Genes Associated with Prostate Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

“BRCAness” Syndrome in Ovarian Cancer: A Case-Control Study Describing the Clinical Features and Outcome of Patients With Epithelial Ovarian Cancer Associated WithBRCA1andBRCA2Mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.3322%2FCAAC.20095

21 January 2018

Identifiers

DOI

10.3322/CAAC.20095

1 reference

23 August 2017

1 reference