(Q34110729)

31 July 2017

1 reference

title

BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair (English)

1 reference

31 July 2017

1 reference

Peter J O'Donovan

1

1 reference

PubMed ID

20400477

31 July 2017

David M Livingston

series ordinal

2

1 reference

PubMed ID

20400477

31 July 2017

language of work or name

English

0 references

publication date

16 April 2010

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31 July 2017

1 reference

31 July 2017

31

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31 July 2017

961-967

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31 July 2017

6

1 reference

BRCA1 and BRCA2: 1994 and beyond

31 July 2017

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Cancer Incidence in BRCA1 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Cancer risks in BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Involvement of Brca2 in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Repair of endogenous DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

DNA double-strand breaks: signaling, repair and the cancer connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

DNA double-strand breaks: their production, recognition, and repair in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The DNA-damage response in human biology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Mechanisms of double-strand break repair in somatic mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Importance of the cell cycle phase for the choice of the appropriate DSB repair pathway, for genome stability maintenance: the trans-S double-strand break repair model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

DNA looping by Ku and the DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Multiple functions of MRN in end-joining pathways during isotype class switching

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The DNA-polymerase-X family: controllers of DNA quality?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

IgH class switching and translocations use a robust non-classical end-joining pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Human CtIP promotes DNA end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Human CtIP mediates cell cycle control of DNA end resection and double strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Identification of Holliday junction resolvases from humans and yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

CCDC98 targets BRCA1 to DNA damage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

BRCA1 promotes induction of ssDNA by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

PALB2 links BRCA1 and BRCA2 in the DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

MDC1 is a mediator of the mammalian DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The BRCT Domain Is a Phospho-Protein Binding Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

BRCT domain-containing protein TopBP1 functions in DNA replication and damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Human TopBP1 ensures genome integrity during normal S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

BRCA1 participates in DNA decatenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

BRCA1 regulates gamma-tubulin binding to centrosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The BRCA2 gene product functionally interacts with p53 and RAD51

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

BRCA2 is required for homology-directed repair of chromosomal breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

BRCA2 deficiency in mice leads to meiotic impairment and infertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

How the fanconi anemia pathway guards the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Gene-Expression Profiles in Hereditary Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Repair of DNA lesions in chromosomal DNA impact of chromatin structure and Cockayne syndrome proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Rapid accessibility of nucleosomal DNA in yeast on a second time scale

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

The emerging role of nuclear architecture in DNA repair and genome maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

PARP is important for genomic stability but dispensable in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Poly(ADP-ribose): novel functions for an old molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

Rag mutations reveal robust alternative end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ069

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGQ069

1 reference

31 July 2017

1 reference

PubMed ID

20400477