(Q37924094)

25 August 2017

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title

Targeting cancer metabolism: a therapeutic window opens (English)

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25 August 2017

author name string

Matthew G Vander Heiden

series ordinal

1

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25 August 2017

publication date

31 August 2011

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Nature Reviews Drug Discovery

25 August 2017

published in

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25 August 2017

volume

10

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25 August 2017

issue

9

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25 August 2017

page(s)

671-684

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

25 August 2017

cites work

1 reference

Principles of cancer therapy: oncogene and non-oncogene addiction

31 March 2020

1 reference

Targeting metabolic transformation for cancer therapy.

31 March 2020

1 reference

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

31 March 2020

1 reference

Regulation of cancer cell metabolism

31 March 2020

1 reference

Non-[18F]FDG PET in clinical oncology

31 March 2020

1 reference

18F-FDG PET and PET/CT in the evaluation of cancer treatment response

31 March 2020

1 reference

Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues

31 March 2020

1 reference

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

31 March 2020

1 reference

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

31 March 2020

1 reference

mTOR: from growth signal integration to cancer, diabetes and ageing

31 March 2020

1 reference

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

31 March 2020

1 reference

Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

31 March 2020

1 reference

Insulin and insulin-like growth factor signalling in neoplasia

31 March 2020

1 reference

Cellular metabolic stress: considering how cells respond to nutrient excess.

31 March 2020

1 reference

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

31 March 2020

1 reference

Fasting serum glucose level and cancer risk in Korean men and women

31 March 2020

1 reference

Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphocytic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen

31 March 2020

1 reference

Impact of diabetes mellitus on outcomes in patients with colon cancer

31 March 2020

1 reference

Pretreatment prognostic factors for survival in small-cell lung cancer: a new prognostic index and validation of three known prognostic indices on 341 patients

31 March 2020

1 reference

Metformin and reduced risk of cancer in diabetic patients

31 March 2020

1 reference

Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

31 March 2020

1 reference

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

31 March 2020

1 reference

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

31 March 2020

1 reference

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

31 March 2020

1 reference

Tumours with PI3K activation are resistant to dietary restriction

31 March 2020

1 reference

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

31 March 2020

1 reference

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

31 March 2020

1 reference

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo.

31 March 2020

1 reference

Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis

31 March 2020

1 reference

Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial

31 March 2020

1 reference

Metformin and other biguanides in oncology: advancing the research agenda

31 March 2020

1 reference

Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer

31 March 2020

1 reference

Sunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor response

31 March 2020

1 reference

Ras, PI(3)K and mTOR signalling controls tumour cell growth

31 March 2020

1 reference

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

31 March 2020

1 reference

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

31 March 2020

1 reference

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

31 March 2020

1 reference

Cancer's insatiable appetite

31 March 2020

1 reference

Exploring the genomes of cancer cells: progress and promise

31 March 2020

1 reference

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

31 March 2020

1 reference

CT and PET: early prognostic indicators of response to imatinib mesylate in patients with gastrointestinal stromal tumor

31 March 2020

1 reference

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

31 March 2020

1 reference

Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC.

31 March 2020

1 reference

Implications for KRAS status and EGFR-targeted therapies in metastatic CRC.

31 March 2020

1 reference

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

31 March 2020

1 reference

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

31 March 2020

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

31 March 2020

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Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.

31 March 2020

1 reference

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

31 March 2020

1 reference

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

31 March 2020

1 reference

Cancer chemotherapy--the first twenty-five years

31 March 2020

1 reference

Timeline: Chemotherapy and the war on cancer.

31 March 2020

1 reference

Dual requirement of Walker carcinosarcoma 256 in vitro for asparagine and glutamine

31 March 2020

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Engineering the substrate specificity of Escherichia coli asparaginase. II. Selective reduction of glutaminase activity by amino acid replacements at position 248.

31 March 2020

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Asparaginase-induced derangements of glutamine metabolism: the pathogenetic basis for some drug-related side-effects.

31 March 2020

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Regulation of glutaminase activity and glutamine metabolism

31 March 2020

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THE EFFECT OF ARGINASE ON THE RETARDATION OF TUMOUR GROWTH.

31 March 2020

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Arginine deiminase, a potential anti-tumor drug

31 March 2020

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A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients

31 March 2020

1 reference

Proliferation in human gastrointestinal epithelium using bromodeoxyuridine in vivo: data for different sites, proximity to a tumour, and polyposis coli

31 March 2020

1 reference

Cell production rates in human tissues and tumours and their significance. Part II: clinical data

31 March 2020

1 reference

Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis

31 March 2020

1 reference

The role of apoptosis in cancer development and treatment response

31 March 2020

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ATP citrate lyase inhibition can suppress tumor cell growth

31 March 2020

1 reference

Use of Dinitrophenol in Nutritional Disorders : A Critical Survey of Clinical Results

31 March 2020

1 reference

Current and potential applications of clinical 13C MR spectroscopy

31 March 2020

1 reference

New approaches for imaging tumour responses to treatment

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Tumor suppressors and cell metabolism: a recipe for cancer growth

31 March 2020

1 reference

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

31 March 2020

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

31 March 2020

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Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation

31 March 2020

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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

31 March 2020

1 reference

Metabolic modulation of glioblastoma with dichloroacetate

31 March 2020

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Over-expression of facilitative glucose transporter genes in human cancer.

31 March 2020

1 reference

Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer.

31 March 2020

1 reference

Sugar-free approaches to cancer cell killing

31 March 2020

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Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death

31 March 2020

1 reference

Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas.

31 March 2020

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Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme

31 March 2020

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Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy.

31 March 2020

1 reference

Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy

31 March 2020

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Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

31 March 2020

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Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

31 March 2020

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Disruption of the hexokinase-VDAC complex for tumor therapy

31 March 2020

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Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

31 March 2020

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Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate

31 March 2020

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Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

31 March 2020

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Isolation and characterization of the human pyruvate kinase M gene

31 March 2020

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

31 March 2020

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

31 March 2020

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Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation

31 March 2020

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Identification of small molecule inhibitors of pyruvate kinase M2

31 March 2020

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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

31 March 2020

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Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

31 March 2020

1 reference

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer.

31 March 2020

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Ras transformation requires metabolic control by 6-phosphofructo-2-kinase

31 March 2020

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The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase

31 March 2020

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The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate

31 March 2020

1 reference

Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231.

31 March 2020

1 reference

Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation

31 March 2020

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Monocarboxylate transporter MCT1 is a target for immunosuppression

31 March 2020

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The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein

31 March 2020

1 reference

The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

31 March 2020

1 reference

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

31 March 2020

1 reference

Nampt: linking NAD biology, metabolism and cancer

31 March 2020

1 reference

Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool

31 March 2020

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Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

31 March 2020

1 reference

The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor

31 March 2020

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NAMPT in regulated NAD biosynthesis and its pivotal role in human metabolism.

31 March 2020

1 reference

An integrated genomic analysis of human glioblastoma multiforme

31 March 2020

1 reference

IDH1 and IDH2 mutations in gliomas

31 March 2020

1 reference

Recurring mutations found by sequencing an acute myeloid leukemia genome

31 March 2020

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

31 March 2020

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

31 March 2020

1 reference

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

31 March 2020

1 reference

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

31 March 2020

1 reference

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

31 March 2020

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

31 March 2020

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

31 March 2020

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

31 March 2020

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

31 March 2020

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

31 March 2020

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Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death.

31 March 2020

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

31 March 2020

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Alternative fuel--another role for p53 in the regulation of metabolism

31 March 2020

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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

31 March 2020

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Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

31 March 2020

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Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

31 March 2020

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Glutamine metabolism in lymphocytes of the rat.

31 March 2020

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

31 March 2020

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Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

31 March 2020

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Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice

31 March 2020

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Does G6PD deficiency protect against cancer? A critical review

31 March 2020

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Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism?

31 March 2020

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Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect

31 March 2020

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The Action of Pteroylglutamic Conjugates on Man.

31 March 2020

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Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid

31 March 2020

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Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and purine antagonists

31 March 2020

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Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma

31 March 2020

1 reference

Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. I. Course of transplanted cancers of various kinds in mice and rats given guinea pig serum, horse serum, or rabbit serum

31 March 2020

1 reference

Evidence that the L-Asparaginase Activity of Guinea Pig Serum is responsible for its Antilymphoma Effects

31 March 2020

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E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children

31 March 2020

1 reference

Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?

31 March 2020

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

31 March 2020

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

31 March 2020

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Fatty acid synthase as a potential therapeutic target in cancer

31 March 2020

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ATP citrate lyase is an important component of cell growth and transformation

31 March 2020

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Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival

31 March 2020

1 reference

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

31 March 2020

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Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

31 March 2020

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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

31 March 2020

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Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

31 March 2020

1 reference

A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.

31 March 2020

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12 December 2020

Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor

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12 December 2020

Hyperglycaemia: link to excess mortality

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12 December 2020

PET imaging of prostate cancer with 11C-acetate

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12 December 2020

Effects of 2-deoxyglucose on drug-sensitive and drug-resistant human breast cancer cells: toxicity and magnetic resonance spectroscopy studies of metabolism.

1 reference

12 December 2020

Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-D-glucose

1 reference

12 December 2020

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis

1 reference

12 December 2020

Reduction of G1 phase duration and enhancement of c-myc gene expression in HeLa cells at hypergravity

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12 December 2020

Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4

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12 December 2020

Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis

1 reference

12 December 2020

Metabolic genes in cancer: their roles in tumor progression and clinical implications

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12 December 2020

High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers

1 reference

12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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12 December 2020

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

1 reference

12 December 2020

Genotoxic exposure is associated with alterations in glucose uptake and metabolism.

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12 December 2020

Identifiers

DOI

10.1038/NRD3504

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25 August 2017

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