(Q43283508)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19718054%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death (English)

1 reference

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6 February 2020

1 reference

1 reference

8

1 reference

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6 February 2020

Eyal Gottlieb

11

1 reference

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6 February 2020

Daniel A Tennant

1

1 reference

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6 February 2020

Christian Frezza

2

1 reference

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6 February 2020

Darren Roberts

7

1 reference

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6 February 2020

author name string

E D MacKenzie

3

1 reference

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6 February 2020

Q D Nguyen

4

1 reference

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6 February 2020

L Zheng

5

1 reference

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6 February 2020

M A Selak

6

1 reference

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6 February 2020

D G Watson

9

1 reference

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6 February 2020

E O Aboagye

10

1 reference

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6 February 2020

language of work or name

English

0 references

publication date

31 August 2009

1 reference

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6 February 2020

1 reference

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6 February 2020

volume

28

1 reference

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6 February 2020

issue

45

1 reference

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6 February 2020

page(s)

4009-4021

1 reference

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

6 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Genetic instability: the dark side of the hypoxic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Exploiting tumour hypoxia in cancer treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

A conserved family of prolyl-4-hydroxylases that modify HIF

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Hypoxia-inducible factor: roles in development, physiology, and disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

HIF-dependent antitumorigenic effect of antioxidants in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Cellular response to tissue hypoxia and its involvement in disease progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Activation of the HIF pathway in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Microenvironment-induced cancer metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Oxygen sensing by HIF hydroxylases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Targeting HIF-1 for cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

The role of oxygen availability in embryonic development and stem cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Characterization and comparative analysis of the EGLN gene family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Assay of citric acid cycle intermediates and related compounds--update with tissue metabolite levels and intracellular distribution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.250

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.250

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19718054%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 February 2020

1017598156

0 references

1 reference