(Q40246572)

English

Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease.

scientific article published on February 2006

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scholarly article

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28 December 2019

Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease (English)

1 reference

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28 December 2019

phosphorylation

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Parkinson's disease

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2

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28 December 2019

author name string

Alan P Kozikowski

1

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28 December 2019

Pavel A Petukhov

3

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28 December 2019

Jayalakshmi Sridhar

4

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28 December 2019

LaShaunda T King

5

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28 December 2019

Sylvie Y Blond

6

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28 December 2019

Tetyana Duka

7

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28 December 2019

Milan Rusnak

8

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28 December 2019

Anita Sidhu

9

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28 December 2019

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publication date

1 February 2006

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28 December 2019

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28 December 2019

1

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28 December 2019

2

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28 December 2019

256-266

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28 December 2019

Pharmacological inhibitors of glycogen synthase kinase 3.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

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A molecular mechanism for the effect of lithium on development

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

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Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Alzheimer's disease: a cell biological perspective

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct association of presenilin-1 with beta-catenin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

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Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

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Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of an altered form of tau in Sf9 insect cells results in the assembly of polymers resembling Alzheimer's paired helical filaments.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for alpha-synuclein in the regulation of dopamine biosynthesis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and in vitro characterization of 1-(4-aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic acid derivatives. A new class of selective GSK-3 inhibitors.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

4-Acylamino-6-arylfuro[2,3-d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein-based virtual screening of chemical databases. 1. Evaluation of different docking/scoring combinations.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

Consensus scoring for ligand/protein interactions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

inferred from DOI database lookup

How does consensus scoring work for virtual library screening? An idealized computer experiment

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500039

7 January 2021

based on heuristic

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Identifiers

10.1002/CMDC.200500039

1 reference

Europe PubMed Central

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28 December 2019

1 reference

Europe PubMed Central

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28 December 2019

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