(Q30613304)

25 June 2017

title

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. (English)

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25 June 2017

9

P Greengard

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25 June 2017

6

E M Mandelkow

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25 June 2017

M Leost

1

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25 June 2017

C Schultz

2

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25 June 2017

A Link

3

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25 June 2017

Y Z Wu

4

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25 June 2017

J Biernat

5

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25 June 2017

J A Bibb

7

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25 June 2017

G L Snyder

8

1 reference

25 June 2017

D W Zaharevitz

10

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25 June 2017

R Gussio

11

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25 June 2017

A M Senderowicz

12

1 reference

25 June 2017

E A Sausville

13

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25 June 2017

C Kunick

14

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25 June 2017

L Meijer

15

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25 June 2017

language of work or name

English

0 references

publication date

1 October 2000

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25 June 2017

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25 June 2017

volume

267

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25 June 2017

issue

19

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25 June 2017

page(s)

5983-5994

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

25 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Cyclin-dependent kinases: engines, clocks, and microprocessors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Cell multiplication. Peering in and peering out: regulation of and by the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Cell cycle: driving the centrosome cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Beta-catenin: a key mediator of Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Tau in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Proteolysis by presenilins and the renaissance of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Presenilins: structural aspects and posttranslational events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

A brain-specific activator of cyclin-dependent kinase 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

The development and therapeutic potential of protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

CDK inhibition and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Properties and potential-applications of chemical inhibitors of cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Inhibition of cyclin-dependent kinases by purine analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

A molecular mechanism for the effect of lithium on development

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Baculovirus-mediated expression and characterisation of rat glycogen synthase kinase-3 beta, the mammalian homologue of the Drosophila melanogaster zeste-white 3sgg homeotic gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Intra-M phase-promoting factor phosphorylation of cyclin B at the prophase/metaphase transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Caspase-dependent Cdk activity is a requisite effector of apoptotic death events

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01673.X

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

21 January 2018

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

A family of human cdc2-related protein kinases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

d-Fused [1]benzazepines with selective in vitro antitumor activity: synthesis and structure-activity relationships

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

Bidirectional regulation of DARPP-32 phosphorylation by dopamine.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

Abortive oncogeny and cell cycle-mediated events in Alzheimer disease.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

Mitotic signaling by beta-amyloid causes neuronal death

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

Phosphorylation of tau protein by casein kinase-1 converts it to an abnormal Alzheimer-like state.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

Phosphorylation of tau protein by recombinant GSK-3beta: pronounced phosphorylation at select Ser/Thr-Pro motifs but no phosphorylation at Ser262 in the repeat domain

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1046/J.1432-1327.2000.01673.X

Identifiers

DOI

10.1046/J.1432-1327.2000.01673.X

1 reference

25 June 2017

1 reference