(Q40267937)

English

MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease

scientific article published on 14 June 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

19 September 2017

MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

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Alzheimer's disease

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1 reference

based on heuristic

inferred from title

Matthias Gaestel

9

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Europe PubMed Central

PubMed publication ID

19 September 2017

author name string

Ainsley A Culbert

1

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Europe PubMed Central

PubMed publication ID

19 September 2017

Stephen D Skaper

2

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Europe PubMed Central

PubMed publication ID

19 September 2017

David R Howlett

3

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Europe PubMed Central

PubMed publication ID

19 September 2017

Nicholas A Evans

4

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Europe PubMed Central

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19 September 2017

Laura Facci

5

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Europe PubMed Central

PubMed publication ID

19 September 2017

Peter E Soden

6

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Zoe M Seymour

7

1 reference

Europe PubMed Central

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19 September 2017

Florence Guillot

8

1 reference

Europe PubMed Central

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19 September 2017

Jill C Richardson

10

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Europe PubMed Central

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19 September 2017

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publication date

14 June 2006

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Europe PubMed Central

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19 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

19 September 2017

281

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19 September 2017

33

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19 September 2017

23658-23667

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Europe PubMed Central

PubMed publication ID

19 September 2017

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

1 reference

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21 January 2018

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Inflammation, autotoxicity and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Inflammation and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Neuroinflammation in Alzheimer's disease and prion disease.

1 reference

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21 January 2018

Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide

1 reference

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21 January 2018

Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression

1 reference

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21 January 2018

P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Macrophages in CNS remyelination: friend or foe?

1 reference

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21 January 2018

Microglia and the immune pathology of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

1 reference

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21 January 2018

Risk of Alzheimer's disease and duration of NSAID use.

1 reference

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21 January 2018

Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study

1 reference

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21 January 2018

p38 kinase is activated in the Alzheimer's disease brain

1 reference

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21 January 2018

Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer’s disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Properties of the pore-forming P2X7 purinoceptor in mouse NTW8 microglial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Upregulation of death pathway molecules in rat cerebellar granule neurons undergoing apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Microglial tyrosine phosphorylation systems in normal and degenerating brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

MAPKAP kinase-2 is a primary response gene induced by depolarization in PC12 cells and in brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Can toxicogenomics provide information on the bioreactivity of diesel exhaust particles?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Characterization of chemokines and their receptors in the central nervous system: physiopathological implications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Chemokines and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Involvement of inflammatory cytokines in central nervous system injury

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

TNF-alpha transgenic and knockout models of CNS inflammation and degeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Overexpression of tumour necrosis factor alpha in the brain of transgenic mice differentially alters nerve growth factor levels and choline acetyltransferase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513646200

21 January 2018

Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system

1 reference

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21 January 2018

Learning abilities, NGF and BDNF brain levels in two lines of TNF-alpha transgenic mice, one characterized by neurological disorders, the other phenotypically normal

1 reference

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21 January 2018

Deletion of macrophage-inflammatory protein 1 alpha retards neurodegeneration in Sandhoff disease mice

1 reference

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21 January 2018

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

1 reference

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21 January 2018

GROalpha/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation-a role in Alzheimer's disease?

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M513646200

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

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