(Q40291972)

English

Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo

scientific article published on June 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

19 September 2017

Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

author name string

T A Navas

1

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19 September 2017

A N Nguyen

2

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19 September 2017

T Hideshima

3

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Europe PubMed Central

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19 September 2017

M Reddy

4

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19 September 2017

J Y Ma

5

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19 September 2017

E Haghnazari

6

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19 September 2017

M Henson

7

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19 September 2017

E G Stebbins

8

1 reference

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19 September 2017

I Kerr

9

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19 September 2017

G O'Young

10

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19 September 2017

A M Kapoun

11

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19 September 2017

S Chakravarty

12

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19 September 2017

B Mavunkel

13

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19 September 2017

J Perumattam

14

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19 September 2017

G Luedtke

15

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19 September 2017

S Dugar

16

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19 September 2017

S Medicherla

17

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19 September 2017

A A Protter

18

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19 September 2017

G F Schreiner

19

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19 September 2017

K C Anderson

20

1 reference

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19 September 2017

L S Higgins

21

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19 September 2017

publication date

1 June 2006

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19 September 2017

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19 September 2017

20

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19 September 2017

6

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19 September 2017

1017-1027

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19 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.leu.2404200

0 references

Novel therapeutic approaches for multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

On the role of Hsp27 in regulating apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

The Bcl-2 family: roles in cell survival and oncogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Proteasome inhibitors: from research tools to drug candidates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Bortezomib (PS-341): A Novel, First-in-Class Proteasome Inhibitor for the Treatment of Multiple Myeloma and Other Cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Involvement of multiple signaling pathways in follicular lymphoma transformation: p38-mitogen-activated protein kinase as a target for therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Fas-L up-regulation by highly malignant myeloma plasma cells: role in the pathogenesis of anemia and disease progression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Mcl-1 regulation and its role in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Ultraviolet A-induced modulation of Bcl-XL by p38 MAPK in human keratinocytes: post-transcriptional regulation through the 3'-untranslated region

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Ways of dying: multiple pathways to apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

21 January 2018

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

7 January 2021

based on heuristic

inferred from DOI database lookup

GM1, a ganglioside that specifically enhances immunoglobulin production and proliferation in human plasma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

7 January 2021

based on heuristic

inferred from DOI database lookup

Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.LEU.2404200

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

ResearchGate publication ID

0 references

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