(Q40319166)

English

A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology

scientific article published on 9 February 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Alzheimer's disease

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author name string

Y Zhang

1

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

H-L Li

2

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

D-L Wang

3

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

S-J Liu

4

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

J-Z Wang

5

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

publication date

9 February 2006

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Journal of Neural Transmission

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

113

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

1487-1497

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

https://scigraph.springernature.com/pub.10.1007/s00702-005-0421-2

0 references

Role of tau protein in both physiological and pathological conditions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-translational modifications of tau protein in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: a cell biological perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein phosphorylation as a therapeutic target in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylation of tau in PHF

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of glycogen synthase kinase-3 by protein kinase C delta: implications for regulation of tau phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunochemical and biochemical characterization of tau proteins in normal and Alzheimer's disease brains with Alz 50 and Tau-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase 3: a drug target for CNS therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3',5'-cyclic adenosine monophosphate as an intracellular second messenger of luteinizing hormone: application of the forskolin criteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Casein kinase II preferentially phosphorylates human tau isoforms containing an amino-terminal insert. Identification of threonine 39 as the primary phosphate acceptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protein factor essential for microtubule assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective brain microtubule assembly in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer disease proteins (A68) share epitopes with tau but show distinct biochemical properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay of protein kinases using peptides with basic residues for phosphocellulose binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

REVIEW: tau protein pathology in Alzheimer's disease and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16465464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00702-005-0421-2

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

ResearchGate publication ID

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