(Q40323177)

English

PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells

scientific article published on 30 January 2006

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scholarly article

1 reference

Europe PubMed Central

19 September 2017

PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells (English)

1 reference

Europe PubMed Central

19 September 2017

pancreatic cancer

1 reference

based on heuristic

inferred from title

author name string

Bonnie H Y Yeung

1

1 reference

Europe PubMed Central

19 September 2017

Der-Chen Huang

2

1 reference

Europe PubMed Central

19 September 2017

Frank A Sinicrope

3

1 reference

Europe PubMed Central

19 September 2017

language of work or name

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publication date

30 January 2006

1 reference

Europe PubMed Central

19 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

19 September 2017

281

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Europe PubMed Central

19 September 2017

17

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Europe PubMed Central

19 September 2017

11923-11932

1 reference

Europe PubMed Central

19 September 2017

Cancer statistics, 2004

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

A phase 2 study of bortezomib in relapsed, refractory myeloma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Lysosomes in cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramideand etoposide-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Role of reactive oxygen species (ROS) in apoptosis induction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

A novel Apaf-1-independent putative caspase-2 activation complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Activation of caspase-2 in apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor. A novel function for a caspase prodomain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Defects in regulation of apoptosis in caspase-2-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

STAT1-induced apoptosis is mediated by caspases 2, 3, and 7.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508533200

21 January 2018

Identifiers

10.1074/JBC.M508533200

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

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