(Q40334600)

English

The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein

scientific article published on March 2010

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scholarly article

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Europe PubMed Central

PMC publication ID

19 September 2017

The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein (English)

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Europe PubMed Central

PMC publication ID

19 September 2017

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Oriana Tabarrini

10

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19 September 2017

Violetta Cecchetti

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19 September 2017

Arianna Loregian

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object named as

Arianna Loregian

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19 September 2017

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object named as

Giorgio Palù

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19 September 2017

Giorgio Gribaudo

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object named as

Giorgio Gribaudo

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19 September 2017

Beatrice Mercorelli

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Beatrice Mercorelli

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19 September 2017

Giulia Muratore

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Giulia Muratore

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19 September 2017

author name string

Elisa Sinigalia

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19 September 2017

Silvana Pagni

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19 September 2017

Barbara Gatto

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19 September 2017

language of work or name

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publication date

1 March 2010

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19 September 2017

Antimicrobial Agents and Chemotherapy

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19 September 2017

54

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19 September 2017

5

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19 September 2017

1930-1940

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19 September 2017

New cell-based indicator assays for the detection of human cytomegalovirus infection and screening of inhibitors of viral immediate-early 2 protein activity.

1 reference

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22 September 2017

Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease.

1 reference

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22 September 2017

Novel inhibitors of human CMV.

1 reference

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22 September 2017

Phosphorothioate-modified oligodeoxynucleotides inhibit human cytomegalovirus replication by blocking virus entry.

1 reference

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22 September 2017

Human cytomegalovirus DNA replication: antiviral targets and drugs

1 reference

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22 September 2017

Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism

1 reference

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22 September 2017

Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase

1 reference

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22 September 2017

Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation

1 reference

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22 September 2017

Structure modifications of 6-aminoquinolones with potent anti-HIV activity

1 reference

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22 September 2017

The putative zinc finger of the human cytomegalovirus IE2 86-kilodalton protein is dispensable for DNA binding and autorepression, thereby demarcating a concise core domain in the C terminus of the protein

1 reference

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22 September 2017

Inhibition of human cytomegalovirus replication by benzimidazole nucleosides involves three distinct mechanisms

1 reference

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22 September 2017

Antiviral properties of quinolone-based drugs.

1 reference

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22 September 2017

Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423.

1 reference

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22 September 2017

Inhibition of human cytomegalovirus DNA polymerase by C-terminal peptides from the UL54 subunit

1 reference

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22 September 2017

Current and potential therapies for the treatment of herpes-virus infections

1 reference

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22 September 2017

Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets

1 reference

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22 September 2017

Broad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of herpesvirus polymerase inhibitors

1 reference

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22 September 2017

Identification and characterization of a benzothiophene inhibitor of herpes simplex virus type 1 replication which acts at the immediate early stage of infection

1 reference

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22 September 2017

Inhibition of cytomegalovirus immediate early gene expression: a therapeutic option?

1 reference

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22 September 2017

Nonnucleoside pyrrolopyrimidines with a unique mechanism of action against human cytomegalovirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863603

22 September 2017

Transcription factor Sp1 mediates cell-specific trans-activation of the human cytomegalovirus DNA polymerase gene promoter by immediate-early protein IE86 in glioblastoma U373MG cells.

1 reference

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22 September 2017

The variable 3' ends of a human cytomegalovirus oriLyt transcript (SRT) overlap an essential, conserved replicator element.

1 reference

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22 September 2017

Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863603

22 September 2017

Eleven loci encoding trans-acting factors are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA replication.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863603

22 September 2017

Site-specific binding of the human cytomegalovirus IE2 86-kilodalton protein to an early gene promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863603

22 September 2017

Inhibition of human cytomegalovirus in culture by alkenyl guanine analogs of the thiazolo[4,5-d]pyrimidine ring system

1 reference

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22 September 2017

A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate

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22 September 2017

A human cytomegalovirus glycoprotein complex designated gC-II is a major heparin-binding component of the envelope

1 reference

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Sequence of protein synthesis in cells infected by human cytomegalovirus: early and late virus-induced polypeptides

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Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative

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Antagonists of Nucleic Acid Derivatives Viii. Synergism in Combinations of Biochemically Related Antimetabolites

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25 September 2017

2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections

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Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses

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25 September 2017

6-Aminoquinolones as new potential anti-HIV agents.

1 reference

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25 September 2017

A 6-aminoquinolone compound, WC5, with potent and selective anti-human cytomegalovirus activity

1 reference

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Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B

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Structure-activity relationship study on anti-HIV 6-desfluoroquinolones

1 reference

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Assessment of CMV load in solid organ transplant recipients by pp65 antigenemia and real-time quantitative DNA PCR assay: correlation with pp67 RNA detection.

1 reference

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20 August 2018

Identifiers

10.1128/AAC.01730-09

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

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