(Q40340040)

English

Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells

scientific article published on 14 December 2005

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

author name string

Narimantas Cenas

1

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Stefanie Prast

2

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Henrikas Nivinskas

3

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Jonas Sarlauskas

4

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Elias S J Arnér

5

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

language of work or name

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publication date

14 December 2005

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

281

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

5593-5603

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Physiological functions of thioredoxin and thioredoxin reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Active sites of thioredoxin reductases: why selenoproteins?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

The mechanism of high Mr thioredoxin reductase from Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Interactions of quinones with thioredoxin reductase: a challenge to the antioxidant role of the mammalian selenoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Thioredoxin reductase as a pathophysiological factor and drug target

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Regulation of the mammalian selenoprotein thioredoxin reductase 1 in relation to cellular phenotype, growth, and signaling events.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

The thioredoxin system—From science to clinic

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

The 58 kDa mouse selenoprotein is a BCNU-sensitive thioredoxin reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Human thioredoxin reductase is efficiently inhibited by (2,2':6',2' '-terpyridine)platinum(II) complexes. Possible implications for a novel antitumor strategy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Radicals from one-electron reduction of nitro compounds, aromatic N-oxides and quinones: the kinetic basis for hypoxia-selective, bioreductive drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Mutagenicity of nitroaromatic compounds

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Biodegradation of nitroaromatic compounds

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Antiplasmodial activity of nitroaromatic and quinoidal compounds: redox potential vs. inhibition of erythrocyte glutathione reductase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Comparison of the cytotoxicity of two nitroheterocyclic drugs (NHCD) towards transformed and non-transformed cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Assessment of production conditions for efficient use of Escherichia coli in high-yield heterologous recombinant selenoprotein synthesis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Quantitative structure-activity relationships in enzymatic single-electron reduction of nitroaromatic explosives: implications for their cytotoxicity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Bioreductive activation of quinones: redox properties and thiol reactivity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Reductive activation of nitroheterocyclic compounds

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Quinone reductase-mediated nitro-reduction: clinical applications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Selenocysteine in proteins-properties and biotechnological use.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Exploiting the 21st amino acid-purifying and labeling proteins by selenolate targeting.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Comparison of the protective activities generated by two survival proteins: Bcl-2 and Hsp27 in L929 murine fibroblasts exposed to menadione or staurosporine.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

The Bcl2 family: regulators of the cellular life-or-death switch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Cytochrome C-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

NAD(P)H:flavin mononucleotide oxidoreductase inactivation during 2,4,6-trinitrotoluene reduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Nitroreductase reactions of Arabidopsis thaliana thioredoxin reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511972200

21 January 2018

Identifiers

10.1074/JBC.M511972200

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

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