(Q35718400)

9 August 2017

1 reference

title

Quinone reductase-mediated nitro-reduction: clinical applications (English)

1 reference

9 August 2017

Richard J Knox

1

1 reference

PubMed ID

15047103

9 August 2017

Shiuan Chen

series ordinal

2

1 reference

PubMed ID

15047103

9 August 2017

language of work or name

English

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publication date

1 January 2004

1 reference

9 August 2017

Methods in Enzymology

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9 August 2017

382

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9 August 2017

194-221

1 reference

DT diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and properties

9 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2)

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Metabolism of benzo(a)pyrene-3,6-quinone and 3-hydroxybenzo(a)pyrene in liver microsomes from 3-methylcholanthrene-treated rats. A possible role of DT-diaphorase in the formation of glucuronyl conjugates

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Relationship between the rate of reduction of benzo(a)pyrene-3,6-quinone and the formation of benzo(a)pyrene-3,6-quinol glucuronides in rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Formation of benzo[a]pyrene-3,6-quinol mono- and diglucuronides in rat liver microsomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Prodrugs in cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

NAD(P)H:quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Use of quinones in brain-tumor therapy: preliminary results of preclinical laboratory investigations.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Regulation of genes encoding NAD(P)H:quinone oxidoreductases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

High levels of expression of the NAD(P)H:Quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

DT-diaphorase and cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

NAD(P)H: quinone oxidoreductase 1 expression in human bone marrow endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs?

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

CB 1954 revisited. II. Toxicity and antitumour activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Identification, synthesis and properties of 5-(aziridin-1-yl)-2-nitro-4-nitrosobenzamide, a novel DNA crosslinking agent derived from CB1954.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

The metabolism of the anti-tumour agent 5-(1-aziridinyl)-2,4-dinitrobenzamide (CB 1954)

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Human DT-diaphorase, a potential cancer protecting enzyme. Its purification from abdominal adipose tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Demonstration of the activation of prodrug CB 1954 using human DT-diaphorase mutant Q104Y-transfected MDA-MB-231 cells and mouse xenograft model

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

The properties of total adducts and interstrand crosslinks in the DNA of cells treated with CB 1954. Exceptional frequency and stability of the crosslink

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Virtual cofactors for an Escherichia coli nitroreductase enzyme: Relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT)

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Nitroreductase-mediated cell ablation is very rapid and mediated by a p53-independent apoptotic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Inducible ablation of adipocytes in adult transgenic mice expressing the E. coli nitroreductase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Conditional ablation of neurones in transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Selective ablation of olfactory receptor neurons without functional impairment of vomeronasal receptor neurons in OMP-ntr transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Enzymatic oxidation of some non-phosphorylated derivatives of dihydronicotinamide.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Metabolism of NAD(P)H by blood components. Relevance to bioreductively activated prodrugs in a targeted enzyme therapy system

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Purification and localization of a 25-kD porcine renal puromycin aminonucleoside-binding protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Identification of the melatonin-binding site MT3 as the quinone reductase 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 .

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

A two-domain structure for the two subunits of NAD(P)H:quinone acceptor oxidoreductase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

Structure-function studies of DT-diaphorase (NQO1) and NRH: quinone oxidoreductase (NQO2).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

CB 1954: From the Walker Tumor to NQO2 and VDEPT

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2982011-1

7 January 2021

10.1016/S0076-6879(04)82011-1

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

15047103