(Q44289559)

1 December 2017

title

Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase (English)

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1 December 2017

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1

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1 December 2017

9

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1 December 2017

Claire J Anderson

2

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1 December 2017

Aileen J Fletcher-Monaghan

3

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1 December 2017

Fiona McGregor

4

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1 December 2017

T R Jeffry Evans

5

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1 December 2017

Ian Ganly

6

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1 December 2017

Richard J Knox

7

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1 December 2017

Jane A Plumb

8

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1 December 2017

language of work or name

English

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publication date

1 January 2003

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1 December 2017

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1 December 2017

volume

22

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1 December 2017

issue

3

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1 December 2017

page(s)

370-380

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1206168

1 December 2017

exact match

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cites work

Prodrug activation enzymes in cancer gene therapy

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

A gene therapy/targeted radiotherapy strategy for radiation cell kill by.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

Expression of telomerase RNA in oesophageal and oral cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

Role of telomerase in cellular proliferation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

Inactivation of MED-1 elements in the TATA-less, initiator-less mouse thymidylate synthase promoter has no effect on promoter strength or the complex pattern of transcriptional start sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

Modulation of the specificity and activity of a cellular promoter in an adenoviral vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Correct usage of multiple transcription initiation sites and C/EBP-dependent transcription activation of the rat XDH/XO TATA-less promoter requires downstream elements located in the coding region of the gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Nitroreductase-mediated cell ablation is very rapid and mediated by a p53-independent apoptotic pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

A highly selective telomerase inhibitor limiting human cancer cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Transcriptional control elements and complex initiation pattern of the TATA-less bidirectional human thymidylate synthase promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

The RNA component of human telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Discovering novel chemotherapeutic drugs for the third millennium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Inhibition of telomerase limits the growth of human cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

A simplified system for generating recombinant adenoviruses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Natural and pharmacological regulation of telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Is small cell lung cancer the perfect target for anti-telomerase treatment?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Structural biology in drug design: selective protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

A survey of telomerase activity in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Tumour specific regulation of telomerase RNA gene expression visualized by in situ hybridization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Insulation of a conditionally expressed transgene in an adenoviral vector

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Telomerase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Telomerase in (pre)neoplastic cervical disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Activation of telomerase rna gene promoter activity by NF-Y, Sp1, and the retinoblastoma protein and repression by Sp3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Cloning and characterization of human and mouse telomerase RNA gene promoter sequences

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206168

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206168

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Dimensions Publication ID

1 December 2017

1018915984

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1 reference