(Q40346993)

English

Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein tra

scientific article published on 25 November 2005

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein tra (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

author name string

Tracy M Wagner

1

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

James E Mullally

2

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

F A Fitzpatrick

3

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

language of work or name

0 references

publication date

25 November 2005

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

19 September 2017

281

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

2598-2604

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

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Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins

1 reference

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Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase

1 reference

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Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

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A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

1 reference

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

1 reference

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21 January 2018

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

1 reference

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

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The AMP-activated protein kinase pathway--new players upstream and downstream.

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Increased risk of cancer in the Peutz-Jeghers syndrome

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Translation initiation and its deregulation during tumorigenesis

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mTOR, translational control and human disease.

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Correlation of Staining for LKB1 and COX-2 in Hamartomatous Polyps and Carcinomas from Patients with Peutz–Jeghers Syndrome

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21 January 2018

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.

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Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome

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21 January 2018

Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages

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21 January 2018

15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.

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15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit

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Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues.

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Thioredoxin as a molecular target of cyclopentenone prostaglandins.

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Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

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Induction of redox instability of bovine myoglobin by adduction with 4-hydroxy-2-nonenal

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Anti-inflammatory lipid mediators and insights into the resolution of inflammation

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Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

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21 January 2018

Identifiers

10.1074/JBC.M509723200

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

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