(Q40390189)

20 September 2017

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title

The clinical potential of renin inhibitors and angiotensin antagonists (English)

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20 September 2017

R J Cody

1

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20 September 2017

publication date

1 April 1994

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20 September 2017

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20 September 2017

volume

47

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20 September 2017

issue

4

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20 September 2017

page(s)

586-598

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https://scigraph.springernature.com/pub.10.2165/00003495-199447040-00003

20 September 2017

exact match

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cites work

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12 December 2020

Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites

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12 December 2020

Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors

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12 December 2020

Why renin inhibitors?

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12 December 2020

Renin gene expression, biosynthesis, and cellular pathways of secretion

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12 December 2020

Differentiation of angiotensin-converting enzyme (ACE) inhibitors by their selective inhibition of ACE in physiologically important target organs

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12 December 2020

Nonpeptide angiotensin II receptor antagonists. Studies with EXP9270 and DuP 753.

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12 December 2020

H-77: a potent new renin inhibitor. In vitro and in vivo studies.

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12 December 2020

A carboxy-terminus truncated analogue of angiotensin II, [Sar1]angiotensin II-(1-7)-amide, provides an entry to a new class of angiotensin II antagonists

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Potential role of the tissue renin-angiotensin system in the pathophysiology of congestive heart failure

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12 December 2020

Specific inhibition of renin by an angiotensinogen analog: studies in sodium depletion and renin-dependent hypertension

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12 December 2020

Effect of renin inhibitor, ES-8891, on renal renin secretion and storage in the marmoset: comparison with captopril

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12 December 2020

The nonpeptide angiotensin II antagonist DuP 753 is a potent stimulus for prostacyclin synthesis

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12 December 2020

Hypotensive action of DuP 753, an angiotensin II antagonist, in spontaneously hypertensive rats. Nonpeptide angiotensin II receptor antagonists: X

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12 December 2020

Peptide to glycopeptide: glycosylated oligopeptide renin inhibitors with attenuated in vivo clearance properties

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12 December 2020

A pharmacodynamic study of the renin inhibitor SR 43,845, administered intratracheally in conscious cynomolgus monkeys

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12 December 2020

A substrate analog inhibitor of renin that is effective in vivo

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12 December 2020

Comparative modeling of proteins in the design of novel renin inhibitors

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12 December 2020

Nonpeptide angiotensin II receptor antagonists.

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12 December 2020

Determination of dissociation constants of high affinity (pM) human renin inhibitors: application to analogues of ditekiren (U-71,038)

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12 December 2020

Regulation of the expression of the rat angiotensin II receptor mRNA.

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12 December 2020

Implications of local angiotensin production in cardiovascular physiology and pharmacology

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12 December 2020

Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands

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12 December 2020

Structure-activity relationships for the carboxy-terminus truncated analogues of angiotension II, a new class of angiotensin II antagonists

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12 December 2020

Pressor response to 1-sar-8-ala-angiotensin II (saralasin) in hypertensive subjects

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12 December 2020

Competitive inhibitors of renin. A review

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12 December 2020

Conformationally restricted polysubstituted biphenyl derivatives with angiotensin II receptors antagonist properties

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12 December 2020

X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors

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12 December 2020

Effect of the renin response during renin inhibition: oral Ro 42-5892 in normal humans

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12 December 2020

Accentuated Vascular and Endocrine Response to Sq 20881 in Hypertension

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12 December 2020

Localization and differential regulation of angiotensinogen mRNA expression in the vessel wall

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12 December 2020

Haemodynamic Responses to Specific Renin-Angiotensin Inhibitors in Hypertension and Congestive Heart Failure A Review

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12 December 2020

Identification of normal neurohormonal activity in mild congestive heart failure and stimulating effect of upright posture and diuretics

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12 December 2020

Angiotensin II Receptor Heterogeneity

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12 December 2020

Estimation of angiotensin II receptor activity in chronic congestive heart failure

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12 December 2020

Renin-specific antibody for study of cardiovascular homeostasis

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12 December 2020

Nonpeptidic angiotensin II antagonists: synthesis and in vitro activity of a series of novel naphthalene and tetrahydronaphthalene derivatives

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Mechanisms governing the postural response and baroreceptor abnormalities in chronic congestive heart failure: effects of acute and long-term converting-enzyme inhibition

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12 December 2020

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12 December 2020

C-terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties

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12 December 2020

Design of a well-absorbed renin inhibitor

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12 December 2020

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors

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12 December 2020

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Hemodynamics of a new angiotensin antagonist, [Sar1, Thr8]A II, in hypertensive man.

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1,2,3-trisubstituted cyclopropanes as conformationally restricted peptide isosteres: application to the design and synthesis of novel renin inhibitors

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12 December 2020

Angiotensin analogs: the influence of sarcosine substituted in position 1.

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12 December 2020

Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension

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12 December 2020

Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).

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12 December 2020

Molecular modeling of renin inhibitor P2 substituents

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12 December 2020

Responses to renin inhibition in conscious primates

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12 December 2020

New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin

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12 December 2020

Conceptual and therapeutic approaches to inhibition of the renin-angiotensin system in chronic heart failure

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12 December 2020

Existence of renin in the endothelium of human artery

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12 December 2020

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12 December 2020

Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent

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12 December 2020

Renin inhibitors: discovery and development. An overview and perspective

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12 December 2020

Some properties of angiotensin converting enzyme in the lung in vivo

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12 December 2020

In vitro evaluation of the plasma and blood compatibility of a parenteral formulation for ditekiren, a novel renin inhibitor pseudopeptide

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12 December 2020

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12 December 2020

Emerging role of the tissue renin-angiotensin systems in congestive heart failure

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12 December 2020

Circulatory autoregulation in chronic congestive heart failure: Responses to head-up tilt in 41 patients

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12 December 2020

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12 December 2020

Nonpeptide renin inhibitors employing a novel 3-aza(or oxa)-2,4-dialkyl glutaric acid moiety as a P2/P3 amide bond replacement

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12 December 2020

Renin inhibitors containing C-termini derived from mercaptoheterocycles

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12 December 2020

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12 December 2020

Acute and chronic effects of renin inhibitor GR70982 in the conscious marmoset

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12 December 2020

Dose-ranging study of the angiotensin type I receptor antagonist losartan (DuP753/MK954), in salt-deplete normal man

1 reference

12 December 2020

Different types of receptor interaction of peptide and nonpeptide angiotensin II antagonists revealed by receptor binding and functional studies

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12 December 2020

Renin- and non-renin–mediated antihypertensive actions of converting enzyme inhibitors

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12 December 2020

Immunologic approaches to blockade of the renin-angiotensin system: a review

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12 December 2020

Role of the renin-angiotensin system in blood pressure regulation. The cardiovascular effects of converting enzyme inhibition in normotensive subjects

1 reference

12 December 2020

Renin Inhibitors. I. Synthesis and Structure-Activity Relationships of Transition-State Inhibitors Containing Homostatine Analogues at the Scissile Bond

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12 December 2020

Hemodynamic effects of renin inhibition by enalkiren in chronic congestive heart failure

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12 December 2020

Kinetics of the reaction of renin with nine synthetic peptide substrates

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12 December 2020

Renin inhibitors: a search for principles of design

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12 December 2020

Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers. Inhibition of pressor response to exogenous angiotensin I and II.

1 reference

12 December 2020

Neurohormonal influences in the pathogenesis of congestive heart failure

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12 December 2020

Acute hypertension in a nonhuman primate: humoral and hemodynamic mechanisms

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12 December 2020

Fate of angiotensin I in the circulation

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12 December 2020

Hemodynamic effects of a competitive renin inhibitory peptide in humans: evidence for multiple mechanisms of action

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12 December 2020

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors

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12 December 2020

Slow, tight binding to human renin of some nonpeptidic renin inhibitors containing a 4-methoxymethoxypiperidinylamide at the P4 position

1 reference

12 December 2020

Action of angiotensin antagonists and antiserum upon the pressor response to renin: further evidence for the local generation of angiotensin II

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12 December 2020

Binding characteristics and vascular effects of various angiotensin II antagonists

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12 December 2020

Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD)

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12 December 2020

Pharmacological Properties of YM-21095, A Potent and Highly Specific Renin Inhibitor

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12 December 2020

10.2165/00003495-199447040-00003

Identifiers

DOI

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Dimensions Publication ID

20 September 2017

1047019303

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