(Q40391856)

20 September 2017

1 reference

title

Site-directed mutagenesis of HIV reverse transcriptase to probe enzyme processivity and drug binding (English)

1 reference

20 September 2017

2

S. H. Wilson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7520785

14 May 2024

author name string

W. A. Beard

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7520785

14 May 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=7520785

14 May 2024

publication date

1 August 1994

1 reference

full work available at URL

20 September 2017

https://api.elsevier.com/content/article/PII:0958166994900515?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

https://api.elsevier.com/content/article/PII:0958166994900515?httpAccept=text/plain

14 May 2024

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Current Opinion in Biotechnology

14 May 2024

published in

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20 September 2017

volume

5

1 reference

20 September 2017

issue

4

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20 September 2017

page(s)

414-421

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HIV resistance to reverse transcriptase inhibitors

20 September 2017

cites work

1

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

14 May 2024

HIV drug resistance

2

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

14 May 2024

4

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation

14 May 2024

11

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Conformational coupling in DNA polymerase fidelity

14 May 2024

12

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Kinetic analysis of template.primer interactions with recombinant forms of HIV-1 reverse transcriptase

14 May 2024

13

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

14 May 2024

15

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

pol mutations conferring zidovudine and didanosine resistance with different effects in vitro yield multiply resistant human immunodeficiency virus type 1 isolates in vivo

14 May 2024

16

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

14 May 2024

17

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Sequence analysis of reverse transcriptase genes of zidovudine (AZT)-resistant and -sensitive human immunodeficiency virus type 1 strains

14 May 2024

20

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Zidovudine treatment results in the selection of human immunodeficiency virus type 1 variants whose genotypes confer increasing levels of drug resistance.

14 May 2024

21

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

HIV and multidrug resistance.

14 May 2024

22

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro

14 May 2024

23

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

14 May 2024

24

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Resistance to 2',3'-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase

14 May 2024

25

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Interactions of the HIV-1 reverse transcriptase 'AZT-resistant' mutant with substrates and AZT-TP.

14 May 2024

26

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

14 May 2024

27

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

14 May 2024

28

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate.

14 May 2024

29

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo

14 May 2024

30

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Two step binding of HIV-1 reverse transcriptase to nucleic acid substrates

14 May 2024

32

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Kinetics of interaction of HIV reverse transcriptase with primer/template

14 May 2024

33

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures

14 May 2024

34

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Interaction of fluorescently labeled dideoxynucleotides with HIV-1 reverse transcriptase

14 May 2024

35

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Influence of template primary structure on 3'-azido-3'-deoxythymidine triphosphate incorporation into DNA

14 May 2024

36

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Identification of the nucleotide binding site of HIV-1 reverse transcriptase using dTTP as a photoaffinity label

14 May 2024

37

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Identification of the amino acid in the human immunodeficiency virus type 1 reverse transcriptase involved in the pyrophosphate binding of antiviral nucleoside triphosphate analogs and phosphonoformate. Implications for multiple drug resistance.

14 May 2024

38

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Structure/function studies of HIV-1(1) reverse transcriptase: dimerization-defective mutant L289K

14 May 2024

39

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Identification of the primer binding domain in human immunodeficiency virus reverse transcriptase

14 May 2024

40

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Characterization of the dimerization process of HIV-1 reverse transcriptase heterodimer using intrinsic protein fluorescence

14 May 2024

41

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors

14 May 2024

42

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

A nonnucleoside reverse transcriptase inhibitor active on human immunodeficiency virus type 1 isolates resistant to related inhibitors

14 May 2024

44

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase

14 May 2024

47

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase

14 May 2024

49

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus.

14 May 2024

55

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

HIV-1 reverse transcriptase: inhibition by 2',5'-oligoadenylates.

14 May 2024

57

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

Antiviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase occur in specific RNA structural regions

14 May 2024

60

1 reference

https://api.crossref.org/works/10.1016/0958-1669(94)90051-5

14 May 2024

Identifiers

1 reference

20 September 2017

1 reference