(Q40395486)

20 September 2017

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title

Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy (English)

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20 September 2017

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2

R N Brogden

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20 September 2017

R Davis

1

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20 September 2017

publication date

1 September 1994

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20 September 2017

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20 September 2017

volume

48

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20 September 2017

issue

3

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20 September 2017

page(s)

431-454

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Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells

20 September 2017

cites work

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12 December 2020

Tolerability of nimesulide and ketoprofen in paediatric patients with traumatic or surgical fractures

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12 December 2020

Gastrointestinal toxicity of newer NSAIDs

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12 December 2020

Clinical experience with nimesulide in gynecologic inflammatory pathology

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12 December 2020

Distribution of oral nimesulide in female genital tissues

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12 December 2020

A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children.

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12 December 2020

Comparison of the systemic inhibition of thromboxane synthesis, anti-inflammatory activity and gastro-intestinal toxicity of non-steroidal anti-inflammatory drugs in the rat

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12 December 2020

Renal and general tolerability of repeated doses of nimesulide in normal subjects

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12 December 2020

Inhibition of neutrophil oxidative metabolism by nimesulide

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12 December 2020

Oral challenge with alternative nonsteroidal antiinflammatory drugs (NSAIDs) and paracetamol in patients intolerant to these agents.

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12 December 2020

Release of platelet-activating factor is important for the respiratory burst induced in human eosinophils by opsonized particles

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12 December 2020

A double-blind comparison of nimesulide and mefenamic acid in the treatment of acute upper respiratory tract infections in children

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12 December 2020

Double-blind evaluation of nimesulide vs lysine-aspirin in the treatment of paediatric acute respiratory tract infections

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12 December 2020

Nimesulide decreases superoxide production by inhibiting phosphodiesterase type IV

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12 December 2020

A double-blind study of the efficacy of nimesulide in the treatment of ankle sprain in comparison with placebo

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12 December 2020

Nimesulide. New clinical opportunities

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12 December 2020

A clinical assessment of the potential for pharmacological interaction between nimesulide and digoxin in patients with heart failure

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12 December 2020

Double-blind, randomised, multi-centre clinical study evaluating the efficacy and tolerability of nimesulide in comparison with etodalac in patients suffering from osteoarthritis of the knee.

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12 December 2020

Antipyretic and platelet antiaggregating effects of nimesulide.

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12 December 2020

Efficacy and tolerability of nimesulide in asthmatic patients intolerant to aspirin

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12 December 2020

Controlled clinical investigation of acute analgesic activity of nimesulide in pain after oral surgery

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12 December 2020

Antianaphylactic and antihistaminic activity of the non-steroidal anti-inflammatory compound nimesulide in guinea-pig

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12 December 2020

The anti-inflammatory drug nimesulide rescues alpha-1-proteinase inhibitor from oxidative inactivation by phagocytosing neutrophils

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12 December 2020

Inhibition of neutrophil function in vitro by nimesulide. Preliminary evidence of an adenosine-mediated mechanism

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12 December 2020

Tolerability of nimesulide in aspirin-sensitive patients

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12 December 2020

Double-blind comparison of nimesulide and diclofenac in the treatment of superficial thrombophlebitis with telethermographic assessment

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12 December 2020

Inactivation of alpha-1-proteinase inhibitor by neutrophil metalloproteinases. Crucial role of the myeloperoxidase system and effects of the anti-inflammatory drug nimesulide

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12 December 2020

First dose and steady state pharmacokinetics of nimesulide and its 4-hydroxy metabolite in healthy volunteers

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12 December 2020

Antipyretic effects of nimesulide in paediatric practice: a double-blind study

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12 December 2020

Efficacy and tolerability of nimesulide in elderly patients with osteoarthritis: double-blind trial versus naproxen

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12 December 2020

A comparison of nimesulide and placebo in the treatment of minor traumatic soft tissue lesions in children.

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12 December 2020

Controlled clinical studies of nimesulide in the treatment of urogenital inflammation.

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12 December 2020

Effect of age and disease on the pharmacokinetics of nimesulide.

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12 December 2020

A multicentre double-blind investigation comparing nimesulide and naproxen in the treatment of minor sport injuries

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12 December 2020

A sulphonamido-indanone derivative CGP 28237 (ZK 34228), a novel non-steroidal anti-inflammatory agent without gastro-intestinal ulcerogenicity in rats

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12 December 2020

Nimesulide and diclofenac in the control of cancer-related pain. Comparison between oral and rectal administration

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12 December 2020

Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst

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12 December 2020

A comparison of nimesulide and diclofenac in the treatment of acute superficial thrombophlebitis.

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12 December 2020

Pharmacokinetics and pharmacodynamics of slow-release theophylline during treatment with nimesulide

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12 December 2020

Nimesulide granules for the treatment of acute inflammation of the ear, nose or throat

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12 December 2020

Nimesulide in the treatment of hyperpyrexia in the aged. Double-blind comparison with paracetamol.

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12 December 2020

Clinical study of the efficacy of and tolerance to nimesulide in suppository formulation in pain-inflammatory pathologies of the ear, nose, and throat

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12 December 2020

Tolerability of nimesulide. Epidemiological data.

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12 December 2020

Clinical study on pharmacological interaction between nimesulide and warfarin

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12 December 2020

Nimesulide inhibits platelet-activating factor synthesis in activated human neutrophils

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12 December 2020

Comparison of nimesulide and flurbiprofen in the treatment of non-infectious acute inflammation of the upper respiratory tract

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12 December 2020

Comparison of nimesulide and diclofenac in the prevention and treatment of painful inflammatory postoperative complications of general surgery.

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12 December 2020

Clinical and pharmacokinetic study of nimesulide in children

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12 December 2020

A controlled clinical study of the efficacy and tolerability of nimesulide vs naproxen in maxillo-facial surgery.

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12 December 2020

Nimesulide binding to components within blood

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12 December 2020

Drug interactions with nimesulide.

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12 December 2020

Comparison of the bioavailability of 2 different equal-dosage oral pharmaceutic forms of nimesulide in healthy volunteers

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12 December 2020

A double-blind comparison of nimesulide and ketoprofen in dental surgery.

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12 December 2020

[Nimesulide in the treatment of primary dysmenorrhea. Comparative clinical evaluation with mefenamic acid and fentiazac]

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12 December 2020

[New therapeutic prospects in gynecologic inflammation: nimesulide]

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12 December 2020

Antipyretic and anti-inflammatory efficacy of nimesulide vs paracetamol in the symptomatic treatment of acute respiratory infections in children

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12 December 2020

Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne. 1st communication: antiinflammatory, analgesic and other related properties

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12 December 2020

Nimesulide in the treatment of advanced cancer pain. Double-blind comparison with naproxen

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12 December 2020

Clinical efficacy and tolerability of nimesulide compared with naproxen in the treatment of posthaemorrhoidectomy pain and inflammation

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12 December 2020

Renal effects of nimesulide in furosemide-treated subjects

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12 December 2020

Antiinflammatory-antioxidant treatment with a methane sulfonanilide in allergen-induced asthma

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12 December 2020

Long term tolerability profile of nimesulide in the treatment of osteoarthritis

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12 December 2020

The role of interleukins and nitric oxide in the mediation of inflammatory pain and its control by peripheral analgesics.

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12 December 2020

Post-marketing survey of nimesulide in the short-term treatment of osteoarthritis

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12 December 2020

The pharmacokinetic profile of nimesulide in healthy volunteers

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12 December 2020

Efficacy and tolerability of nimesulide and lysine-acetylsalicylate in the treatment of paediatric acute upper respiratory tract inflammation.

1 reference

12 December 2020

Effects of nimesulide and naproxen on the degradation and metalloprotease synthesis of human osteoarthritic cartilage

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12 December 2020

Nimesulide in the treatment of osteoarthritis. Double-blind studies in comparison with piroxicam, ketoprofen and placebo

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12 December 2020

Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis

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12 December 2020

Nimesulide. A preliminary review of its pharmacological properties and therapeutic efficacy in inflammation and pain states

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12 December 2020

The effect of nimesulide on prostanoid formation.

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12 December 2020

Antioxidant profile of nimesulide, indomethacin and diclofenac in phosphatidylcholine liposomes (PCL) as membrane model

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12 December 2020

Nonsteroidal anti-inflammatory drug nephrotoxicity. Should we be concerned?

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12 December 2020

An assessment of the efficacy and tolerability of nimesulide vs paracetamol in children after adenotonsillectomy

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12 December 2020

A comparison of nimesulide and ketoprofen in the prevention and treatment of painful postoperative inflammatory complications of ear, nose and throat surgery.

1 reference

12 December 2020

Assessment of the efficacy and safety of nimesulide vs naproxen in paediatric patients with respiratory tract infections. A comparative single-blind study.

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12 December 2020

Inactivation of neutrophil-derived hypochlorous acid by nimesulide: a potential mechanism for the tissue protection during inflammation

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12 December 2020

Tissue destruction by neutrophils

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12 December 2020

Double-blind study of nimesulide in divers with inflammatory disorders of the ear, nose and throat

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12 December 2020

Antioxidant activity of nimesulide and its main metabolites

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12 December 2020

Pharmacokinetics and therapeutic study with nimesulide suppositories in children with post-operative pain and inflammation

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12 December 2020

Nimesulide in the treatment of pelvic inflammatory diseases. A multicentre clinical trial conducted in Campania and Sicily.

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12 December 2020

Renal syndromes associated with nonsteroidal antiinflammatory drugs

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12 December 2020

Free radicals in medicine. II. Involvement in human disease

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12 December 2020

Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8

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12 December 2020

Double-blind study evaluating by endoscopy the tolerability of nimesulide and diclofenac on the gastric mucosa in osteoarthritic patients

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12 December 2020

10.2165/00003495-199448030-00008

Identifiers

DOI

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Dimensions Publication ID

20 September 2017

1024343394

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