(Q40401086)

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Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.

scientific article published on July 2005

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16000623%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway (English)

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30 December 2019

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5

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30 December 2019

7

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30 December 2019

author name string

Julie Lotharius

1

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30 December 2019

Jeppe Falsig

2

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30 December 2019

Johan van Beek

3

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30 December 2019

Sarah Payne

4

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30 December 2019

Patrik Brundin

6

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30 December 2019

language of work or name

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publication date

1 July 2005

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30 December 2019

Journal of Neuroscience

1 reference

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30 December 2019

25

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30 December 2019

27

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30 December 2019

6329-6342

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Europe PubMed Central

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30 December 2019

describes a project that uses

0 references

CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

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MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

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The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

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Role of mitochondrial dysfunction and dopamine-dependent oxidative stress in amphetamine-induced toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

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beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

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In vivo and in vitro evidence for extracellular caspase activity released from apoptotic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Methamphetamine causes coordinate regulation of Src, Cas, Crk, and the Jun N-terminal kinase-Jun pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Methamphetamine-induced apoptosis in a CNS-derived catecholaminergic cell line.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

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The neuromelanin of human substantia nigra and its interaction with metals

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

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A single methamphetamine administration rapidly decreases vesicular dopamine uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

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Glutathione depletion and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

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K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Mice with partial deficiency of c-Jun show attenuation of methamphetamine-induced neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Activation of the c-Jun N terminal kinase pathway in an animal model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione pathways in the brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal dopamine-quinone synthesis: A review

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular patch electrochemistry: regulation of cytosolic catecholamines in chromaffin cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of c-Jun N-terminal kinase (JNK) in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The true face of JNK activation in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

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JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Improvement of embryonic dopaminergic neurone survival in culture and after grafting into the striatum of hemiparkinsonian rats by CEP-1347.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Mixed-lineage kinases: a target for the prevention of neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Iron-melanin complex in substantia nigra of parkinsonian brains: an x-ray microanalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

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The relevance of iron in the pathogenesis of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Methamphetamine causes depletion of glutathione and an increase in oxidized glutathione in the rat striatum and prefrontal cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Iron, brain ageing and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Role of dopamine in the neurotoxic effects of methamphetamine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methamphetamine-induced neuronal damage: a possible role for free radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

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Methamphetamine: toxicity to dopaminergic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pretreatment with ascorbic acid attenuates the neurotoxic effects of methamphetamine in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased dopamine metabolism in the rat neostriatum after toxic doses of d-methylamphetamine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further evidence that amphetamines produce long-lasting dopamine neurochemical deficits by destroying dopamine nerve fibers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-methyltyrosine attenuates and reserpine increases methamphetamine-induced neuronal changes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling of dopamine oxidation (monoamine oxidase activity) to glutathione oxidation via the generation of hydrogen peroxide in rat brain homogenates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of oxygen-based radicals in methamphetamine-induced neurotoxicity: evidence from the use of CuZnSOD transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuromelanin and nigrostriatal dopamine neuron degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K-252a and staurosporine promote choline acetyltransferase activity in rat spinal cord cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reserpine inhibits amphetamine action in ventral midbrain culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione content as an indicator for the presence of metabolic pathways of amino acids in astroglial cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AP-1 DNA-binding activation by methamphetamine involves oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of mice with methamphetamine produces cell loss in the substantia nigra.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methamphetamine induces apoptosis in immortalized neural cells: protection by the proto-oncogene, bcl-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CEP-1347/KT7515 prevents motor neuronal programmed cell death and injury-induced dedifferentiation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat striatal levels of the antioxidant glutathione are decreased following binge administration of methamphetamine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox regulation of caspase-3(-like) protease activity: regulatory roles of thioredoxin and cytochrome c

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16000623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1746-05.2005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16000623%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16000623%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16000623%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

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