(Q40413218)

20 September 2017

title

The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions (English)

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20 September 2017

Munehisa Yabuki

1

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20 September 2017

Monica M Fujii

series ordinal

2

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20 September 2017

Nancy Maizels

series ordinal

3

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20 September 2017

language of work or name

English

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publication date

5 June 2005

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20 September 2017

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20 September 2017

volume

6

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20 September 2017

issue

7

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20 September 2017

page(s)

730-736

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

20 September 2017

cites work

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

21 January 2018

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AID is essential for immunoglobulin V gene conversion in a cultured B cell line

21 January 2018

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

21 January 2018

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

21 January 2018

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Repair and genetic consequences of endogenous DNA base damage in mammalian cells

21 January 2018

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

21 January 2018

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

21 January 2018

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Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

21 January 2018

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Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.

21 January 2018

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AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

21 January 2018

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The AID enzyme induces class switch recombination in fibroblasts

21 January 2018

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

21 January 2018

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The MRN complex: coordinating and mediating the response to broken chromosomes

21 January 2018

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

21 January 2018

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Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

21 January 2018

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The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

21 January 2018

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The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

21 January 2018

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Checking on DNA damage in S phase

21 January 2018

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AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

21 January 2018

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Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

21 January 2018

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Nibrin functions in Ig class-switch recombination

21 January 2018

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Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.

21 January 2018

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ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region

21 January 2018

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Delineation of the role of the Mre11 complex in class switch recombination

21 January 2018

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Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

21 January 2018

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Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

21 January 2018

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Hypersensitivity of cells from a new chromosomal-breakage syndrome to DNA-damaging agents

21 January 2018

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

21 January 2018

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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

21 January 2018

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TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

21 January 2018

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Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

21 January 2018

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AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization

21 January 2018

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Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

21 January 2018

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

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Immunoglobulin gene diversification

21 January 2018

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Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.

21 January 2018

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Internal IgH class switch region deletions are position-independent and enhanced by AID expression

21 January 2018

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Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

21 January 2018

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

21 January 2018

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Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

21 January 2018

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A hyperconversion mechanism generates the chicken light chain preimmune repertoire.

21 January 2018

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Germ line maintenance of the pseudogene donor pool for somatic immunoglobulin gene conversion in chickens

21 January 2018

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Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage

21 January 2018

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The cellular response to DNA double-strand breaks: defining the sensors and mediators

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Alternative end joining during switch recombination in patients with ataxia-telangiectasia

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NI1215

1 reference

20 September 2017

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