(Q40431257)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15849364%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase (English)

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11 January 2020

2

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11 January 2020

Barbara Acosta-Iborra

3

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11 January 2020

Julian Aragones Lopez

7

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11 January 2020

author name string

Elisa Temes

1

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11 January 2020

Maria C Castellanos

4

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11 January 2020

Mónica Feijoo-Cuaresma

5

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11 January 2020

Gemma Olmos

6

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11 January 2020

Manuel O Landazuri

8

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11 January 2020

language of work or name

English

0 references

publication date

23 April 2005

1 reference

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Journal of Biological Chemistry

11 January 2020

published in

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11 January 2020

volume

280

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11 January 2020

issue

25

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11 January 2020

page(s)

24238-24244

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Hypoxia-inducible factor and its biomedical relevance

11 January 2020

cites work

1 reference

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Signal transduction to hypoxia-inducible factor 1

21 January 2018

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

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Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

21 January 2018

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Molecular basis of the VHL hereditary cancer syndrome

21 January 2018

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 January 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

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Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

21 January 2018

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 January 2018

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HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels

21 January 2018

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

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The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen

21 January 2018

1 reference

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Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

21 January 2018

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

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HIF hydroxylation and the mammalian oxygen-sensing pathway

21 January 2018

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Signal transduction. How do cells sense oxygen?

21 January 2018

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Role of diacylglycerol induced by hypoxia in the regulation of HIF-1alpha activity

21 January 2018

1 reference

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Selectivity of the diacylglycerol kinase inhibitor 3-[2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl]-2, 3-dihydro-2-thioxo-4(1H)quinazolinone (R59949) among diacylglycerol kinase subtypes

21 January 2018

1 reference

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Molecules in focus: diacylglycerol kinase.

21 January 2018

1 reference

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Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation

21 January 2018

1 reference

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Tumour suppression by the human von Hippel-Lindau gene product

21 January 2018

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Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

21 January 2018

1 reference

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Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes

21 January 2018

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Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation

21 January 2018

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

21 January 2018

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Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

21 January 2018

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Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms.

21 January 2018

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Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?

21 January 2018

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Molecular characterization of a phosphatidylcholine-hydrolyzing phospholipase C.

21 January 2018

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Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway

21 January 2018

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The role of phosphatidic acid in the regulation of the Ras/MEK/Erk signaling cascade

21 January 2018

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Phospholipase D: molecular and cell biology of a novel gene family

21 January 2018

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Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

21 January 2018

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JunD reduces tumor angiogenesis by protecting cells from oxidative stress

21 January 2018

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Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

21 January 2018

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OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

21 January 2018

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Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

21 January 2018

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Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor

21 January 2018

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Targeting HIF-1 for cancer therapy

21 January 2018

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Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells

21 January 2018

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Intratumoral hypoxia, radiation resistance, and HIF-1.

21 January 2018

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Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

21 January 2018

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Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M414694200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15849364%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference