(Q40451716)

English

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.

scientific article published on 15 November 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

20 September 2017

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue. (English)

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Chikungunya virus

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1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

Pratyush Kumar Das

object named as

Pratyush Kumar Das

6

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object named as

Finny S Varghese

4

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object named as

Andres Merits

8

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object named as

Kai Rausalu

1

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7

object named as

Tero Ahola

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

2

object named as

Age Utt

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

author name string

Tania Quirin

3

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Eva Žusinaite

5

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Europe PubMed Central

PMC publication ID

20 September 2017

language of work or name

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publication date

15 November 2016

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Europe PubMed Central

PMC publication ID

20 September 2017

Scientific Reports

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Europe PubMed Central

PMC publication ID

20 September 2017

6

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Europe PubMed Central

PMC publication ID

20 September 2017

37124

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Europe PubMed Central

PMC publication ID

20 September 2017

https://scigraph.springernature.com/pub.10.1038/srep37124

0 references

Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5109220

22 September 2017

Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein

1 reference

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22 September 2017

Ability of minus strands and modified plus strands to act as templates in Semliki Forest virus RNA replication

1 reference

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22 September 2017

Molecular Modeling and Docking Study to Elucidate Novel Chikungunya Virus nsP2 Protease Inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5109220

22 September 2017

Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine

1 reference

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22 September 2017

Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.

1 reference

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22 September 2017

Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion

1 reference

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22 September 2017

Differences in Processing Determinants of Nonstructural Polyprotein and in the Sequence of Nonstructural Protein 3 Affect Neurovirulence of Semliki Forest Virus

1 reference

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22 September 2017

Alphavirus RNA synthesis and non-structural protein functions

1 reference

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Discovery of Novel Peptidomimetics as Irreversible CHIKV NsP2 Protease Inhibitors Using Quantum Mechanical-Based Ligand Descriptors

1 reference

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22 September 2017

Full length and protease domain activity of chikungunya virus nsP2 differ from other alphavirus nsP2 proteases in recognition of small peptide substrates

1 reference

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22 September 2017

Chikungunya: Evolutionary history and recent epidemic spread

1 reference

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22 September 2017

Correlative light and electron microscopy enables viral replication studies at the ultrastructural level

1 reference

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22 September 2017

Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2

1 reference

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22 September 2017

Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity

1 reference

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22 September 2017

Presentation overrides specificity: probing the plasticity of alphaviral proteolytic activity through mutational analysis

1 reference

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22 September 2017

Template RNA length determines the size of replication complex spherules for Semliki Forest virus

1 reference

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22 September 2017

Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus

1 reference

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22 September 2017

Structural and functional insights into alphavirus polyprotein processing and pathogenesis

1 reference

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22 September 2017

Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays

1 reference

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22 September 2017

Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein

1 reference

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22 September 2017

NTPase and 5'-RNA triphosphatase activities of Chikungunya virus nsP2 protein

1 reference

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Heterologous production, purification and characterization of enzymatically active Sindbis virus nonstructural protein nsP1

1 reference

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22 September 2017

Homology modeling, molecular dynamics, e-pharmacophore mapping and docking study of Chikungunya virus nsP2 protease

1 reference

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22 September 2017

Assembly of alphavirus replication complexes from RNA and protein components in a novel trans-replication system in mammalian cells

1 reference

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22 September 2017

Structural basis for substrate specificity of alphavirus nsP2 proteases

1 reference

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22 September 2017

A new role for ns polyprotein cleavage in Sindbis virus replication

1 reference

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22 September 2017

Expression and biochemical characterization of nsP2 cysteine protease of Chikungunya virus

1 reference

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Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery.

1 reference

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22 September 2017

Properly folded nonstructural polyprotein directs the semliki forest virus replication complex to the endosomal compartment

1 reference

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The herpesvirus proteases as targets for antiviral chemotherapy

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Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter

1 reference

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The alphaviruses: gene expression, replication, and evolution

1 reference

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22 September 2017

Processing the nonstructural polyproteins of sindbis virus: nonstructural proteinase is in the C-terminal half of nsP2 and functions both in cis and in trans

1 reference

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Cleavage-site preferences of Sindbis virus polyproteins containing the non-structural proteinase. Evidence for temporal regulation of polyprotein processing in vivo

1 reference

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Identification of the active site residues in the nsP2 proteinase of Sindbis virus

1 reference

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Polypeptide requirements for assembly of functional Sindbis virus replication complexes: a model for the temporal regulation of minus- and plus-strand RNA synthesis

1 reference

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RNA Replication and Membrane Modification Require the Same Functions of Alphavirus Nonstructural Proteins

1 reference

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25 September 2017

Evidence that Sindbis virus NSP2 is an autoprotease which processes the virus nonstructural polyprotein

1 reference

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1 reference

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Molecular determinants of substrate specificity for Semliki Forest virus nonstructural protease

1 reference

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17 June 2018

Proteolytic processing of Semliki Forest virus-specific non-structural polyprotein by nsP2 protease

1 reference

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17 June 2018

The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease

1 reference

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20 August 2018

Characterization of the cysteine protease domain of Semliki Forest virus replicase protein nsP2 by in vitro mutagenesis

1 reference

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20 August 2018

Regulation of the sequential processing of Semliki Forest virus replicase polyprotein

1 reference

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20 August 2018

Site-specific protease activity of the carboxyl-terminal domain of Semliki Forest virus replicase protein nsP2.

1 reference

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20 August 2018

Use of a fluorescence plate reader for measuring kinetic parameters with inner filter effect correction

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20 August 2018

Identifiers

10.1038/SREP37124

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

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