(Q40476559)

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Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway.

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scholarly article

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6 January 2020

Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway (English)

1 reference

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6 January 2020

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Changcheng Zhou

1

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6 January 2020

author name string

Michelle M Tabb

2

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6 January 2020

Asal Sadatrafiei

3

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6 January 2020

Felix Grün

4

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6 January 2020

Aixu Sun

5

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6 January 2020

Bruce Blumberg

6

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6 January 2020

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1 November 2004

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6 January 2020

Journal of Clinical Immunology

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6 January 2020

24

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6 January 2020

6

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6 January 2020

623-636

1 reference

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6 January 2020

https://scigraph.springernature.com/pub.10.1007/s10875-004-6248-z

0 references

Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut.

1 reference

https://api.crossref.org/works/10.1007%2FS10875-004-6248-Z

21 January 2018

Calcium-dependent interleukin-8 gene expression in T84 human colonic epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissection of Ras-dependent signaling pathways controlling aggressive tumor growth of human fibrosarcoma cells: evidence for a potential novel pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome inhibition leads to NF-kappaB-independent IL-8 transactivation in human endothelial cells through induction of AP-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benefits and risks of the hypericum extract LI 160: drug monitoring study with 3250 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 8 secretion by colonic crypt cells in vitro: response to injury suppressed by butyrate and enhanced in inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-transcriptional regulation of gro alpha, beta, gamma, and IL-8 mRNAs by IL-1 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

St John's wort: Prozac from the plant kingdom.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum levels of cytokines in patients with colorectal cancer: possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-8 and human cancer biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB (Review).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epithelial cells as sensors for microbial infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of the benefits, adverse events, drug interactions, and safety of St. John's Wort (Hypericum perforatum): the implications with regard to the regulation of herbal medicines

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GAL4-VP16 is an unusually potent transcriptional activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oct-1 and CCAAT/enhancer-binding protein (C/EBP) bind to overlapping elements within the interleukin-8 promoter. The role of Oct-1 as a transcriptional repressor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A unified nomenclature system for the nuclear receptor superfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's Wort: the role of amiloride sensitive sodium conductive pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological profile of hypericum extract. Effect on serotonin uptake by postsynaptic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK- and p38 MAPK-dependent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional and post-transcriptional regulation of interleukin-8.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical mechanisms of action of Hypericum LI 160 in glial and neuronal cells: inhibition of neurotransmitter uptake and stimulation of extracellular signal regulated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell adhesion and migration. I. Neutrophil adhesive interactions with intestinal epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bacterial DNA evokes epithelial IL-8 production by a MAPK-dependent, NF-kappaB-independent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity profiles of two hyperforin-containing hypericum extracts in behavioral models

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Second thoughts about safety of St John's wort

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

St John's wort, a herbal antidepressant, activates the steroid X receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-8: a very important chemokine of the human airway epithelium.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of interleukin-8 gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligation independent cloning irrespective of restriction site compatibility.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

St John's wort for depression--an overview and meta-analysis of randomised clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanism of interleukin-8 gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypericum perforatum: nature's mood stabilizer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-8 as an autocrine growth factor for human colon carcinoma cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human chemokines: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential involvement of interleukin-8 (IL-8) in acute inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A candidate for cancer gene therapy: MIP-1 alpha gene transfer to an adenocarcinoma cell line reduced tumorigenicity and induced protective immunity in immunocompetent mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

St John's wort for depression: a systematic review

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15622447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10875-004-6248-Z

1 reference

Europe PubMed Central

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6 January 2020

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1 reference

Europe PubMed Central

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6 January 2020

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