(Q40479992)

20 September 2017

title

Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity. (English)

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20 September 2017

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5

Peter Wipf

1 reference

20 September 2017

Sheara W Fewell

1

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20 September 2017

Christine M Smith

2

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20 September 2017

Michael A Lyon

3

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20 September 2017

Teodora Pene Dumitrescu

4

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20 September 2017

Billy W Day

6

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20 September 2017

Jeffrey L Brodsky

7

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20 September 2017

language of work or name

English

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publication date

23 September 2004

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Journal of Biological Chemistry

20 September 2017

published in

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20 September 2017

volume

279

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20 September 2017

issue

49

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20 September 2017

page(s)

51131-51140

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Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

20 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

The peptide-binding domain of the chaperone protein Hsc70 has an unusual secondary structure topology

21 January 2018

1 reference

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Structural analysis of substrate binding by the molecular chaperone DnaK

21 January 2018

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Kinetics of molecular chaperone action

21 January 2018

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Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function

21 January 2018

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Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Mutations in the DnaK chaperone affecting interaction with the DnaJ cochaperone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Mechanism of the targeting action of DnaJ in the DnaK molecular chaperone system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40

21 January 2018

1 reference

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Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein

21 January 2018

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Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Mammalian osmolytes and S-nitrosoglutathione promote Delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) protein maturation and function

21 January 2018

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Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.

21 January 2018

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Role of the heat shock response and molecular chaperones in oncogenesis and cell death

21 January 2018

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Stress management - heat shock protein-70 and the regulation of apoptosis

21 January 2018

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Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications

21 January 2018

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Differential expression of 70-kDa heat shock-protein in human oral tumorigenesis

21 January 2018

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Oncogenic potential of Hsp72.

21 January 2018

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Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

21 January 2018

1 reference

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The virus-chaperone connection

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404857200

The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Identification of an inhibitor of hsc70-mediated protein translocation and ATP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

The ATPase domain of hsp70 possesses a unique binding specificity for 3'-sulfogalactolipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

3'Sulfogalactolipid binding specifically inhibits Hsp70 ATPase activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Combinatorial synthesis and biological evaluation of library of small-molecule Ser/Thr-protein phosphatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Multicomponent Reactions with Isocyanides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Expression of SV40 large T antigen in baculovirus systems and purification by immunoaffinity chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

The dissociation of ATP from hsp70 of Saccharomyces cerevisiae is stimulated by both Ydj1p and peptide substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Mge1 functions as a nucleotide release factor for Ssc1, a mitochondrial Hsp70 of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Sec61p and BiP directly facilitate polypeptide translocation into the ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Intragenic suppressors of Hsp70 mutants: interplay between the ATPase- and peptide-binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Mitochondrial Hsp70 Ssc1: role in protein folding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Virology. Monkey virus link to cancer grows stronger

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

The action of molecular chaperones in the early secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

70K heat shock related proteins stimulate protein translocation into microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Chaperone action in the posttranslational topological reorientation of the hepatitis B virus large envelope protein: Implications for translocational regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Chaperone proteins abrogate inhibition of the human papillomavirus (HPV) E1 replicative helicase by the HPV E2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Activation of the herpes simplex virus type-1 origin-binding protein (UL9) by heat shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1/Oct6/SCIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Mutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

The J-domain family and the recruitment of chaperone power

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

A solid phase protocol of the biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

Function of DnaJ and DnaK as chaperones in origin-specific DNA binding by RepA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404857200

21 January 2018

Identifiers

DOI

10.1074/JBC.M404857200

1 reference

20 September 2017

1 reference