(Q40491653)

21 September 2017

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title

Zidovudine. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy (English)

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21 September 2017

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Michelle I Wilde

1

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PubMed ID

7693435

21 September 2017

Heather D Langtry

series ordinal

2

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21 September 2017

1 September 1993

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21 September 2017

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21 September 2017

46

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21 September 2017

3

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21 September 2017

515-578

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https://scigraph.springernature.com/pub.10.2165/00003495-199346030-00010

21 September 2017

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Zidovudine: a review of pharmacoeconomic and quality-of-life considerations for its use in patients with human immunodeficiency virus

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Long-term safety and efficacy of zidovudine in patients with advanced human immunodeficiency virus disease. Zidovudine Epidemiology Study Group

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12 December 2020

Combination treatment with azidothymidine and granulocyte colony-stimulating factor in children with human immunodeficiency virus infection

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12 December 2020

Recombinant human erythropoietin in the treatment of anemia associated with human immunodeficiency virus (HIV) infection and zidovudine therapy. Overview of four clinical trials

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12 December 2020

Emergence of Mutant HIV Reverse Transcriptase Conferring Resistance to AZT

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12 December 2020

AZT-induced mitochondrial myopathy

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12 December 2020

Amelioration of zidovudine-induced fetal toxicity in pregnant mice

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12 December 2020

Immediate versus deferred zidovudine

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12 December 2020

Dynamic changes in HIV-1 quasispecies from azidothymidine (AZT)-treated patients

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12 December 2020

Neuromuscular complications of HIV infection and its treatment

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12 December 2020

Neurologic disorders associated with HIV infections

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12 December 2020

Low-dose zidovudine in combination with either acyclovir or lymphoblastoid interferon-alpha in asymptomatic HIV-infected patients: a pilot study

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12 December 2020

Mismatched double-stranded RNA (ampligen) reduces concentration of zidovudine (azidothymidine) required for in-vitro inhibition of human immunodeficiency virus

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12 December 2020

Brief report: primary infection with zidovudine-resistant human immunodeficiency virus type 1.

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12 December 2020

Human immunodeficiency virus infection and the skin

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12 December 2020

Surveillance of HIV infection and zidovudine use among health care workers after occupational exposure to HIV-infected blood. The CDC Cooperative Needlestick Surveillance Group

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12 December 2020

Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine

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12 December 2020

Nuclear and mitochondrial changes of muscle fibers in AIDS after treatment with high doses of zidovudine

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12 December 2020

Pharmacokinetics of zidovudine phosphorylation in patients infected with the human immunodeficiency virus

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12 December 2020

Evaluation of the combination effect of different antiviral compounds against HIV in vitro

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12 December 2020

Ultrastructural characteristics and DNA immunocytochemistry in human immunodeficiency virus and zidovudine-associated myopathies

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12 December 2020

Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1

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12 December 2020

Functional status and well-being in a placebo-controlled trial of zidovudine in early symptomatic HIV infection.

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12 December 2020

Physicians not fazed by AZT guidelines

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12 December 2020

HIV-1 biological phenotype and the development of zidovudine resistance in relation to disease progression in asymptomatic individuals during treatment

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12 December 2020

Combination therapy with zidovudine and dideoxycytidine in patients with advanced human immunodeficiency virus infection. A phase I/II study

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12 December 2020

In vitro inhibition of the infectivity and replication of human immunodeficiency virus type 1 by combination of antiretroviral 2',3'-dideoxynucleosides and virus-binding inhibitors

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12 December 2020

Pharmacokinetics of zidovudine alone and in combination with oxazepam in the HIV infected patient

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12 December 2020

3'-Azido-3'-deoxythymidine inhibits globin gene transcription in butyric acid-induced K-562 human leukemia cells

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12 December 2020

Treatment considerations for children with human immunodeficiency virus infection

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12 December 2020

Clinical decisions in the care of elderly persons with AIDS

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12 December 2020

Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases

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12 December 2020

Myopathies associated with human immunodeficiency virus and zidovudine: can their effects be distinguished?

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12 December 2020

New antiretroviral agents in the clinic.

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12 December 2020

Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro

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12 December 2020

Evaluation of multiple parameters of HIV-1 replication cycle in testing of AIDS drugs in vitro

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12 December 2020

The effect of combinations of ampligen and zidovudine or dideoxyinosine against human immunodeficiency viruses in vitro

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12 December 2020

Population pharmacokinetics of zidovudine. The Veterans Administration Cooperative Studies Group

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12 December 2020

Lymphoma in AIDS patients receiving long-term antiretroviral therapy

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12 December 2020

Pharmacokinetics of zidovudine plus probenecid

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12 December 2020

Influence of hemodialysis on zidovudine (AZT) and its glucuronide (GAZT) pharmacokinetics: two case reports

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12 December 2020

Antiviral therapy for human immunodeficiency virus infection in children

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12 December 2020

A Phase I/II Trial of Zidovudine, Interferon- , and Granulocyte-Macrophage Colony-Stimulating Factor in the Treatment of Human Immunodeficiency Virus Type 1 Infection

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12 December 2020

Clinical correlates of in vitro HIV-1 resistance ot zidovudine. Results of the Multicentre Canadian AZT Trial

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12 December 2020

The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection. A double-blind, placebo-controlled trial. The AIDS Clinical Trials Group

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12 December 2020

The effect of antiviral therapy on the natural history of human immunodeficiency virus infection in a cohort of hemophiliacs

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12 December 2020

Changing etiology of macrocytosis. Zidovudine as a frequent causative factor

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12 December 2020

Inosine pranobex in the treatment of HIV infection: A review

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12 December 2020

The efficacy and safety of zidovudine alone or as cotherapy with acyclovir for the treatment of patients with AIDS and AIDS-related complex: a double-blind randomized trial. European-Australian Collaborative Group

1 reference

12 December 2020

Combined toxicity of zidovudine and antituberculosis chemotherapy

1 reference

12 December 2020

Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects

1 reference

12 December 2020

Effect of continuous-infusion zidovudine therapy on neuropsychologic functioning in children with symptomatic human immunodeficiency virus infection.

1 reference

12 December 2020

Zidovudine-induced macular edema

1 reference

12 December 2020

Surrogate markers for survival in patients with AIDS and AIDS related complex treated with zidovudine

1 reference

12 December 2020

Acetaminophen does not impair clearance of zidovudine

1 reference

12 December 2020

Pharmacokinetic disposition of zidovudine during pregnancy

1 reference

12 December 2020

Low-dose interferon alpha combined with zidovudine in patients with AIDS-associated Kaposi's sarcoma

1 reference

12 December 2020

Pharmacokinetic interactions of zidovudine and methadone in intravenous drug-using patients with HIV infection

1 reference

12 December 2020

Failure of prophylactic zidovudine after suicidal self-inoculation of HIV-infected blood

1 reference

12 December 2020

Clinical pharmacokinetics of zidovudine. An overview of current data

1 reference

12 December 2020

Human immunodeficiency virus associated with thrombotic thrombocytopenic purpura: successful treatment with zidovudine

1 reference

12 December 2020

Continuous infusion of zidovudine in HIV related thrombocytopenia.

1 reference

12 December 2020

Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

1 reference

12 December 2020

Effects of discontinuation of zidovudine treatment on zidovudine sensitivity of human immunodeficiency virus type 1 isolates

1 reference

12 December 2020

Zidovudine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy

1 reference

12 December 2020

A sensitive nonisotopic method for the determination of intracellular azidothymidine 5′-mono-, 5′-di-, and 5′-triphosphate

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12 December 2020

Influence of treatment with zidovudine (ZDV) on the long-term survival of AIDS patients

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12 December 2020

Antiviral therapy in human immunodeficiency virus infections. Current status (Part II).

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12 December 2020

Postexposure chemoprophylaxis for occupational exposure to human immunodeficiency virus type 1: current status and prospects for the future

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12 December 2020

A randomized trial of reduced doses of azidothymidine in Japanese patients with human immunodeficiency virus type 1 infection

1 reference

12 December 2020

Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex

1 reference

12 December 2020

A multicenter trial of oral zidovudine in children with advanced human immunodeficiency virus disease. The Protocol 043 Study Group

1 reference

12 December 2020

A controlled trial comparing continued zidovudine with didanosine in human immunodeficiency virus infection. The NIAID AIDS Clinical Trials Group

1 reference

12 December 2020

Serum levels of soluble CD8, neopterin, beta 2-microglobulin and p24 antigen as indicators of disease progression in children with AIDS on zidovudine therapy

1 reference

12 December 2020

Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure

1 reference

12 December 2020

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event

1 reference

12 December 2020

In vitro inhibition of human immunodeficiency virus (HIV) type 1 replication by C2 symmetry-based HIV protease inhibitors as single agents or in combinations

1 reference

12 December 2020

Toxicity of combined ganciclovir and zidovudine for cytomegalovirus disease associated with AIDS. An AIDS Clinical Trials Group Study

1 reference

12 December 2020

Zidovudine after occupational exposure to HIV.

1 reference

12 December 2020

Zidovudine treatment of the AIDS dementia complex: results of a placebo-controlled trial. AIDS Clinical Trials Group

1 reference

12 December 2020

Mother to child transmission of human immunodeficiency virus 1 infection despite zidovudine therapy from 18 weeks of gestation

1 reference

12 December 2020

Combined treatment of symptomatic human immunodeficiency virus type 1 infection with native interferon-alpha and zidovudine

1 reference

12 December 2020

Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)].

1 reference

12 December 2020

Survival of zidovudine-treated patients with AIDS compared with that of contemporary untreated patients. Italian Zidovudine Evaluation Group

1 reference

12 December 2020

Enhancement of HIV-specific cytotoxic T lymphocyte responses by zidovudine (AZT) treatment

1 reference

12 December 2020

Nail and mucocutaneous hyperpigmentation with azidothymidine therapy

1 reference

12 December 2020

Erratic zidovudine bioavailability in HIV seropositive patients

1 reference

12 December 2020

Effects of bone marrow stimulatory cytokines on human immunodeficiency virus replication and the antiviral activity of dideoxynucleosides in cultures of monocyte/macrophages

1 reference

12 December 2020

Excessive growth of eyelashes in a patient with AIDS being treated with zidovudine

1 reference

12 December 2020

Study of human immunodeficiency virus resistance to 2'-3'-dideoxyinosine and zidovudine in sequential isolates from pediatric patients on long-term therapy

1 reference

12 December 2020

Canadian multicenter azidothymidine trial: AZT pharmacokinetics

1 reference

12 December 2020

Zidovudine-induced restoration of cell-mediated immunity to mycobacteria in immunodeficient HIV-infected patients

1 reference

12 December 2020

Detection of zidovudine-resistant variants of HIV-1 in genital fluids

1 reference

12 December 2020

Alternating and intermittent regimens of zidovudine and dideoxycytidine in patients with AIDS or AIDS-related complex.

1 reference

12 December 2020

Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS.

1 reference

12 December 2020

Occupational exposure to HIV and zidovudine chemoprophylaxis

1 reference

12 December 2020

Nail pigmentation associated with zidovudine

1 reference

12 December 2020

Loss of synergistic response to combinations containing AZT in AZT-resistant HIV-1.

1 reference

12 December 2020

Absorption of zidovudine in patients with diarrhoea

1 reference

12 December 2020

Reduced frequency of HIV-induced brain lesions in AIDS patients treated with zidovudine.

1 reference

12 December 2020

Quality of life in a placebo-controlled trial of zidovudine in patients with AIDS and AIDS-related complex

1 reference

12 December 2020

Development of non-Hodgkin lymphoma in a cohort of patients with severe human immunodeficiency virus (HIV) infection on long-term antiretroviral therapy

1 reference

12 December 2020

Effects of granulocyte-macrophage colony-stimulating factor on 3'-azido-3'-deoxythymidine uptake, phosphorylation and nucleotide retention in human U-937 cells

1 reference

12 December 2020

Azidothymidine (zidovudine) transport by the human placenta

1 reference

12 December 2020

Improved brain delivery of AZT using a glycosyl phosphotriester prodrug.

1 reference

12 December 2020

Psoriasis and human immunodeficiency virus infection

1 reference

12 December 2020

Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study

1 reference

12 December 2020

Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

1 reference

12 December 2020

Effect of zidovudine and Pneumocystis carinii pneumonia prophylaxis on progression of HIV-1 infection to AIDS

1 reference

12 December 2020

Didanosine. A review of its antiviral activity, pharmacokinetic properties and therapeutic potential in human immunodeficiency virus infection

1 reference

12 December 2020

HIV transmission by stabbing despite zidovudine prophylaxis

1 reference

12 December 2020

Syngeneic bone marrow transplantation and adoptive transfer of peripheral blood lymphocytes combined with zidovudine in human immunodeficiency virus (HIV) infection

1 reference

12 December 2020

Zidovudine disposition in patients with severe renal impairment: influence of hemodialysis

1 reference

12 December 2020

Combinations of 3'-azido-3'-deoxythymidine (zidovudine) and phosphonoformate (foscarnet) against human immunodeficiency virus type 1 and cytomegalovirus replication in vitro

1 reference

12 December 2020

Nucleoside analogs: similarities and differences

1 reference

12 December 2020

Surrogate markers in AIDS: where are we? Where are we going?

1 reference

12 December 2020

Zidovudine resistance, syncytium-inducing phenotype, and HIV disease progression in a case-control study. The VA Cooperative Study Group

1 reference

12 December 2020

Resistance of HIV-1 to AZT might also involve the cellular expression of multidrug resistance P-glycoprotein

1 reference

12 December 2020

The effects on survival of early treatment of human immunodeficiency virus infection

1 reference

12 December 2020

Clinical manifestations and predictors of disease progression in drug users with human immunodeficiency virus infection

1 reference

12 December 2020

Does zidovudine reduce tumour necrosis factor-alpha in HIV-positive patients?

1 reference

12 December 2020

Pharmacokinetics of oral zidovudine (azidothymidine) in patients with AIDS when administered with and without a high-fat meal

1 reference

12 December 2020

Trimethoprim, alone or in combination with sulphamethoxazole, decreases the renal excretion of zidovudine and its glucuronide

1 reference

12 December 2020

Early identification of human immunodeficiency virus-infected asymptomatic subjects susceptible to zidovudine by quantitative viral coculture and reverse transcription-linked polymerase chain reaction

1 reference

12 December 2020

High-level resistance to zidovudine but not to zalcitabine or didanosine in human immunodeficiency virus from children receiving antiretroviral therapy

1 reference

12 December 2020

Perinatal pharmacokinetics of zidovudine

1 reference

12 December 2020

Safety and effects of interleukin-2 plus zidovudine in asymptomatic individuals infected with human immunodeficiency virus.

1 reference

12 December 2020

Preliminary analysis of the Concorde trial. Concorde Coordinating Committee

1 reference

12 December 2020

Failed prophylactic zidovudine after needlestick injury

1 reference

12 December 2020

HIV seroconversion after occupational exposure despite early prophylactic zidovudine therapy

1 reference

12 December 2020

Treatment options for human immunodeficiency virus-infected pregnant women. Obstetric-Gynecologic Working Group of the AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases

1 reference

12 December 2020

Failure of zidovudine prophylaxis after accidental exposure to HIV-1.

1 reference

12 December 2020

Administration of zidovudine during primary HIV-1 infection may be associated with a less vigorous immune response

1 reference

12 December 2020

Zalcitabine compared with zidovudine in patients with advanced HIV-1 infection who received previous zidovudine therapy

1 reference

12 December 2020

Acquired immunodeficiency syndrome. Cerebrospinal fluid findings in patients before and during long-term oral zidovudine therapy

1 reference

12 December 2020

Fulminant hepatic failure in an AIDS patient: possible zidovudine-induced hepatotoxicity

1 reference

12 December 2020

Granulocyte-macrophage colony-stimulating factor mitigates the neutropenia of combined interferon alfa and zidovudine treatment of acquired immune deficiency syndrome-associated Kaposi's sarcoma

1 reference

12 December 2020

Use of zidovudine following occupational exposure to human immunodeficiency virus

1 reference

12 December 2020

Zidovudine in post-exposure prophylaxis of health-care workers

1 reference

12 December 2020

Reconstitution of long-term T helper cell function after zidovudine therapy in human immunodeficiency virus-infected patients

1 reference

12 December 2020

Didanosine for zidovudine-intolerant patients with HIV disease

1 reference

12 December 2020

Low doses of azidothymidine in the treatment of HIV-1 virus infection

1 reference

12 December 2020

Comparative pharmacokinetics of zidovudine in healthy volunteers and in patients with AIDS with and without hepatic disease

1 reference

12 December 2020

Esophageal ulceration induced by zidovudine

1 reference

12 December 2020

Azidothymidine-induced hyperpigmentation mimicking primary adrenal insufficiency

1 reference

12 December 2020

Augmentation of Cellular Immune Function during the Early Phase of Zidovudine Treatment of AIDS Patients

1 reference

12 December 2020

Long-term treatment with zidovudine in patients with human immunodeficiency virus (HIV)-associated thrombocytopenia: modes of response and correlation with markers of HIV replication

1 reference

12 December 2020

Lymphocytes from HIV-infected individuals show aberrant inositol polyphosphate metabolism which reverses after zidovudine therapy

1 reference

12 December 2020

Incidence of zidovudine-resistant human immunodeficiency virus isolated from patients before, during, and after therapy

1 reference

12 December 2020

Antiproliferative potential of zidovudine in human keratinocyte cultures

1 reference

12 December 2020

Virus neutralizing antibodies at different stages of the HIV disease: increased levels after azidothymidine treatment

1 reference

12 December 2020

Zidovudine therapy in thrombocytopenic human immunodeficiency virus-infected children

1 reference

12 December 2020

Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy

1 reference

12 December 2020

Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex

1 reference

12 December 2020

Acquired immune deficiency syndrome-related pulmonary non-Hodgkin lymphoma regressing after zidovudine therapy

1 reference

12 December 2020

A mutation in human immunodeficiency virus reverse transcriptase and decline in CD4 lymphocyte numbers in long-term zidovudine recipients

1 reference

12 December 2020

Synergistic antiviral effect in vitro of azidothymidine and amphotericin B methyl ester in combination on HIV infection

1 reference

12 December 2020

CD4+ lymphocyte response to zidovudine as a predictor of AIDS-free time and survival time

1 reference

12 December 2020

Intracellular metabolism of 3'-azidothymidine in isolated human peripheral blood mononuclear cells

1 reference

12 December 2020

Phase I evaluation of zidovudine administered to infants exposed at birth to the human immunodeficiency virus

1 reference

12 December 2020

Pharmacokinetic evaluations of low- and high-dose zidovudine plus high-dose acyclovir in patients with symptomatic human immunodeficiency virus infection

1 reference

12 December 2020

Immediate versus deferred zidovudine.

1 reference

12 December 2020

A phase I study of recombinant human interferon-alpha 2a or human lymphoblastoid interferon-alpha n1 and concomitant zidovudine in patients with AIDS-related Kaposi's sarcoma

1 reference

12 December 2020

The long-term use of zidovudine in patients with severe immune-mediated thrombocytopenia secondary to infection with HIV.

1 reference

12 December 2020

Zidovudine treatment of psoriasis associated with acquired immunodeficiency syndrome

1 reference

12 December 2020

The immunopathogenesis of human immunodeficiency virus infection

1 reference

12 December 2020

Zidovudine reverses the defect in dendritic cells in HIV infection

1 reference

12 December 2020

Comparative pharmacokinetics of two prodrugs of zidovudine in rabbits: enhanced levels of zidovudine in brain tissue

1 reference

12 December 2020

Granulocyte-macrophage colony-stimulating factor and zidovudine in the treatment of neutropenia and human immunodeficiency virus infection

1 reference

12 December 2020

Evaluation of saliva as a specimen for monitoring zidovudine therapy in HIV-infected patients

1 reference

12 December 2020

Combination chemoprophylaxis after needlestick injury

1 reference

12 December 2020

Extrahepatic metabolism of zidovudine

1 reference

12 December 2020

Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex

1 reference

12 December 2020

1 reference

12 December 2020

Zidovudine therapy in combination with intravenous immunoglobulin in HIV infected children

1 reference

12 December 2020

Early predictors of survival in symptomatic HIV-infected persons treated with high-dose zidovudine

1 reference

12 December 2020

In vitro measurement of phosphorylated zidovudine in peripheral blood leucocytes

1 reference

12 December 2020

Inhibition of the RNase H activity of HIV reverse transcriptase by azidothymidylate

1 reference

12 December 2020

Pharmacokinetics of concomitantly administered foscarnet and zidovudine for treatment of human immunodeficiency virus infection (AIDS Clinical Trials Group protocol 053)

1 reference

12 December 2020

Trend towards decreased survival in patients infected with HIV resistant to zidovudine

1 reference

12 December 2020

Synergistic activity of granulocyte-macrophage colony-stimulating factor and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro

1 reference

12 December 2020

Intravenous and oral zidovudine pharmacokinetics and coagulation effects in asymptomatic human immunodeficiency virus-infected hemophilia patients

1 reference

12 December 2020

HIV-1 sensitivity to zidovudine and clinical outcome in children

1 reference

12 December 2020

Public Health Service statement on management of occupational exposure to human immunodeficiency virus, including considerations regarding zidovudine postexposure use

1 reference

12 December 2020

Pharmacokinetic interaction between rifampin and zidovudine

1 reference

12 December 2020

Modeling the relationship between survival and CD4 lymphocytes in patients with AIDS and AIDS-related complex

1 reference

12 December 2020

Probenecid and zidovudine metabolism

1 reference

12 December 2020

Sequence analysis of reverse transcriptase genes of zidovudine (AZT)-resistant and -sensitive human immunodeficiency virus type 1 strains

1 reference

12 December 2020

Criticisms of Concorde dominate AIDS conference

1 reference

12 December 2020

Zidovudine and other reverse transcriptase inhibitors in the management of human immunodeficiency virus-related disease

1 reference

12 December 2020

HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy

1 reference

12 December 2020

Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay

1 reference

12 December 2020

CD4+ lymphocytes are an incomplete surrogate marker for clinical progression in persons with asymptomatic HIV infection taking zidovudine

1 reference

12 December 2020

Anti-human immunodeficiency virus agent 3'-azido-3'-deoxythymidine inhibits replication of Epstein-Barr virus

1 reference

12 December 2020

Combined zidovudine and interferon-alpha 2a therapy in children with acquired immune deficiency syndrome

1 reference

12 December 2020

Only temporary improvement in impaired neuropsychological function in AIDS patients treated with zidovudine

1 reference

12 December 2020

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

1 reference

12 December 2020

Zidovudine pharmacokinetics in five HIV seronegative patients undergoing continuous ambulatory peritoneal dialysis

1 reference

12 December 2020

Uncertain future for anti-HIV therapy

1 reference

12 December 2020

Pneumocystis prophylaxis and survival in patients with advanced human immunodeficiency virus infection treated with zidovudine. The Zidovudine Epidemiology Group

1 reference

12 December 2020

Postural hypotension related to zidovudine in a patient infected with HIV

1 reference

12 December 2020

[Pharmacokinetic study of zidovudine in parenteral drug addicts with human immunodeficiency virus infection]

1 reference

12 December 2020

Racial and ethnic differences in outcome in zidovudine-treated patients with advanced HIV disease. Zidovudine Epidemiology Study Group.

1 reference

12 December 2020

Oral mucosa pigmentation: a new side effect of azidothymidine therapy in patients with acquired immunodeficiency syndrome

1 reference

12 December 2020

A pilot study of low-dose zidovudine in human immunodeficiency virus infection

1 reference

12 December 2020

The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

1 reference

12 December 2020

Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection

1 reference

12 December 2020

Neuropsychological outcome of zidovudine (AZT) treatment of patients with AIDS and AIDS-related complex

1 reference

12 December 2020

Zidovudine-interferon-alpha combination therapy in patients with advanced human immunodeficiency virus type 1 infection: biphasic response of p24 antigen and quantitative polymerase chain reaction

1 reference

12 December 2020

Hematologic aspects of HIV infection

1 reference

12 December 2020

Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

1 reference

12 December 2020

Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon.

1 reference

12 December 2020

Nail dyschromia associated with zidovudine

1 reference

12 December 2020

Reversion from zidovudine resistance to sensitivity on cessation of treatment

1 reference

12 December 2020

Cardiomyopathy Associated with Antiretroviral Therapy in Patients with HIV Infection: A Report of Six Cases

1 reference

12 December 2020

Probenecid inhibits the metabolic and renal clearances of zidovudine (AZT) in human volunteers

1 reference

12 December 2020

Effect of zidovudine and granulocyte-macrophage colony-stimulating factor on human immunodeficiency virus replication in alveolar macrophages

1 reference

12 December 2020

Recombinant human granulocyte-macrophage colony-stimulating factor ameliorates zidovudine-induced neutropenia in patients with acquired immunodeficiency syndrome (AIDS)/AIDS-related complex

1 reference

12 December 2020

Synergistic Inhibition of Human Immunodeficiency Virus Replication In Vitro by Combinations of 3′-Azido-3′-Deoxythymidine and 3′-Fluoro-3′-Deoxythymidine

1 reference

12 December 2020

Effects of zidovudine in 30 patients with mild to end-stage AIDS dementia complex.

1 reference

12 December 2020

Concentrations of phosphorylated zidovudine (ZDV) in patient leukocytes do not correlate with ZDV dose or plasma concentrations

1 reference

12 December 2020

1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults

1 reference

12 December 2020

Zidovudine sensitivity of human immunodeficiency viruses from high-risk, symptom-free individuals during therapy

1 reference

12 December 2020

Zidovudine Pharmacokinetics During Pregnancy

1 reference

12 December 2020

Zidovudine toxicity. Clinical features and management

1 reference

12 December 2020

The pharmacokinetics of zidovudine administered by continuous infusion in children

1 reference

12 December 2020

Interferon-alpha, zidovudine, and granulocyte-macrophage colony-stimulating factor: a phase I AIDS Clinical Trials Group study in patients with Kaposi's sarcoma associated with AIDS

1 reference

12 December 2020

Natural history of advanced HIV disease in patients treated with zidovudine. The Zidovudine Epidemiology Study Group

1 reference

12 December 2020

The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

1 reference

12 December 2020

Suppression of p24 antigen in sera from HIV-infected individuals with low-dose alpha-interferon and zidovudine: a pilot study

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12 December 2020

Toxic effects of zidovudine in asymptomatic human immunodeficiency virus-infected individuals with CD4+ cell counts of 0.50 x 10(9)/L or less. Detailed and updated results from protocol 019 of the AIDS Clinical Trials Group

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12 December 2020

Successful zidovudine therapy for HIV-related severe thrombocytopenia. Report of a sustained remission

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12 December 2020

Development of resistance to zidovudine in HIV strains isolated from CD4+ lymphocytes and plasma during therapy

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12 December 2020

Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine

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12 December 2020

Comparison of two dose regimens of zidovudine in an open, randomized, multicentre study for severe HIV-related thrombocytopenia

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12 December 2020

A randomized controlled trial of a reduced daily dose of zidovudine in patients with the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group

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12 December 2020

Dextran sulphate, a potent anti-HIV agent in vitro having synergism with zidovudine

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12 December 2020

Clinical significance of zidovudine-resistant human immunodeficiency viruses

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12 December 2020

Molluscum contagiosum in human immunodeficiency virus infection: response to zidovudine

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12 December 2020

Zalcitabine. A review of its pharmacology and clinical potential in acquired immunodeficiency syndrome (AIDS)

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12 December 2020

Safety and efficacy of polyethylene glycol-modified interleukin-2 and zidovudine in human immunodeficiency virus type 1 infection: a phase I/II study

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12 December 2020

Ribavirin antagonizes the effect of azidothymidine on HIV replication

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12 December 2020

Prognosis in AZT myopathy

1 reference

12 December 2020

Zidovudine now or later?

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12 December 2020

Neopterin and β2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection

1 reference

12 December 2020

Effects of disease stage and zidovudine therapy on the detection of human immunodeficiency virus type 1 in semen

1 reference

12 December 2020

Comparative pharmacokinetics of zidovudine (AZT) and its metabolite (G.AZT) in healthy subjects and HIV seropositive patients

1 reference

12 December 2020

The effect of acetaminophen on zidovudine metabolism in HIV-infected patients

1 reference

12 December 2020

Quality-of-life evaluation in a clinical trial of zidovudine therapy in patients with mildly symptomatic HIV infection. The AIDS Clinical Trials Group

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12 December 2020

Anti-HIV-1 activity of antiviral compounds, as quantitated by a focal immunoassay in CD4+ HeLa cells and a plaque assay in MT-4 cells

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12 December 2020

Progress in the understanding of HIV infection: an overview

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12 December 2020

Three-year follow-up of asymptomatic HIV-infected men receiving combination zidovudine and acyclovir

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12 December 2020

Sodium Pentosan Polysulfate (PPS), an Anti-HIV Agent Also Exhibits Synergism with AZT, Lymphoproliferative Activity, and Virus Enhancement

1 reference

12 December 2020

Human immunodeficiency virus type 1 (HIV-1) inhibitory interactions between protease inhibitor Ro 31-8959 and zidovudine, 2',3'-dideoxycytidine, or recombinant interferon-alpha A against zidovudine-sensitive or -resistant HIV-1 in vitro

1 reference

12 December 2020

Evaluation of the in vivo effect of naproxen on zidovudine pharmacokinetics in patients infected with human immunodeficiency virus

1 reference

12 December 2020

Characterization of HIV isolates arising after prolonged zidovudine therapy

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12 December 2020

Zidovudine with probenecid: a warning

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12 December 2020

Use of self-sustained sequence replication amplification reaction to analyze and detect mutations in zidovudine-resistant human immunodeficiency virus

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12 December 2020

Glucuronidation of 3'-azido-3'-deoxythymidine by rat and human liver microsomes.

1 reference

12 December 2020

Isolation of AIDS-associated retrovirus from genital secretions of women with antibodies to the virus

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12 December 2020

Somber news from the AIDS front

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12 December 2020

A method for the quantification of intracellular zidovudine nucleotides

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12 December 2020

Pharmacokinetics of single and chronic dose zidovudine in two HIV positive patients undergoing continuous ambulatory peritoneal dialysis (CAPD)

1 reference

12 December 2020

Multiple-dose pharmacokinetics of oral zidovudine in hemophilia patients with human immunodeficiency virus infection

1 reference

12 December 2020

The effect of a protein meal on zidovudine pharmacokinetics in HIV-infected patients

1 reference

12 December 2020

Double blind dose-response study of zidovudine in AIDS and advanced HIV infection. Nordic Medical Research Councils' HIV Therapy Group

1 reference

12 December 2020

Two-Drug Combinations of Zidovudine, Didanosine, and Recombinant Interferon- A Inhibit Replication of Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Synergistically In Vitro

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12 December 2020

Clinical pharmacokinetics of 3'-azido-3'-deoxythymidine (zidovudine) and catabolites with formation of a toxic catabolite, 3'-amino-3'-deoxythymidine

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12 December 2020

In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine

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12 December 2020

A controlled trial of early versus late treatment with zidovudine in symptomatic human immunodeficiency virus infection. Results of the Veterans Affairs Cooperative Study

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12 December 2020

The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes

1 reference

12 December 2020

Resumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidine

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12 December 2020

Three-drug synergistic inhibition of HIV-1 replication in vitro by zidovudine, recombinant soluble CD4, and recombinant interferon-alpha A

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12 December 2020

The efficacy and safety of zidovudine with or without acyclovir in the treatment of patients with AIDS-related complex. The European-Australian Collaborative Group

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12 December 2020

Zidovudine-associated adverse reactions in a longitudinal study of asymptomatic HIV-1-infected homosexual males

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12 December 2020

Strategies for antiviral therapy in AIDS.

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12 December 2020

Anti-human immunodeficiency virus effects of dextran sulfate are strain dependent and synergistic or antagonistic when dextran sulfate is given in combination with dideoxynucleosides

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12 December 2020

In vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir

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12 December 2020

Zidovudine after occupational exposure to HIV

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12 December 2020

Synergistic inhibition of human immunodeficiency virus type 1 replication in vitro by two-drug and three-drug combinations of 3'-azido-3'-deoxythymidine, phosphonoformate, and 2',3'-dideoxythymidine

1 reference

12 December 2020

Didanosine and zidovudine resistance patterns in clinical isolates of human immunodeficiency virus type 1 as determined by a replication endpoint concentration assay

1 reference

12 December 2020

Presentation and course of AIDS dementia complex: 10 years of follow-up in Amsterdam, The Netherlands.

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12 December 2020

Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells

1 reference

12 December 2020

Comparative pharmacokinetics of antiviral nucleoside analogues

1 reference

12 December 2020

HIV infection in children

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12 December 2020

Hepatomegaly with severe steatosis in HIV-seropositive patients

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12 December 2020

Zidovudine: five years later

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12 December 2020

Drug interactions with zidovudine

1 reference

12 December 2020

Influence of probenecid and paracetamol (acetaminophen) on zidovudine glucuronidation in human liver in vitro

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12 December 2020

Mitochondrial myopathy caused by long-term zidovudine therapy

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12 December 2020

Development and significance of zidovudine resistance in children infected with human immunodeficiency virus

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12 December 2020

A survey of zidovudine use in pregnant women with human immunodeficiency virus infection

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12 December 2020

HIV infection in older patients: when to suspect the unexpected.

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12 December 2020

Interferon-alpha with zidovudine: safety, tolerance, and clinical and virologic effects in patients with Kaposi sarcoma associated with the acquired immunodeficiency syndrome (AIDS)

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12 December 2020

Biological comparison of wild-type and zidovudine-resistant isolates of human immunodeficiency virus type 1 from the same subjects: susceptibility and resistance to other drugs

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12 December 2020

Relationship and prognostic value of endogenous interferon-alpha, beta 2-microglobulin, and neopterin serum levels in patients with Kaposi sarcoma and AIDS

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12 December 2020

Zidovudine-induced leukocytoclastic vasculitis

1 reference

12 December 2020

Combined therapy with recombinant granulocyte colony-stimulating factor and erythropoietin decreases hematologic toxicity from zidovudine

1 reference

12 December 2020

Isolation of drug-resistant variants of HIV-1 from patients on long-term zidovudine therapy

1 reference

12 December 2020

Neurological and neuropsychological performance in HIV seropositive men without symptoms

1 reference

12 December 2020

Zidovudine therapy of HIV-1 infection during pregnancy: assessment of the effect on the newborns.

1 reference

12 December 2020

Prolonged zidovudine therapy in patients with AIDS and advanced AIDS-related complex. AZT Collaborative Working Group

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12 December 2020

Effects of antiretroviral dideoxynucleosides on polymorphonuclear leukocyte function

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12 December 2020

Combined zidovudine and interferon-alpha treatment in patients with AIDS-associated Kaposi's sarcoma

1 reference

12 December 2020

Challenges in the therapy of HIV infection

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12 December 2020

10.2165/00003495-199346030-00010

Identifiers

DOI

1 reference

PubMed ID

7693435

Dimensions Publication ID

21 September 2017

0 references

1 reference

PubMed ID

7693435